CORONA Main Coronavirus thread

Heliobas Disciple

TB Fanatic
(fair use applies)


Friday is the last day US consumers can place mail orders for free COVID tests from the government

By WYATTE GRANTHAM-PHILIPS
March 8, 2024

NEW YORK (AP) — The U.S. government is suspending mail orders for free COVID-19 tests — at least for now.

Friday March 8 is the last day residential households can request free virus tests shipped through the United States Postal Service. According to the Administration for Strategic Preparedness and Response, a division of the U.S. Health and Human Services Department, orders are set to close at 11:59 p.m. PT.

“ASPR has delivered over 1.8 billion free COVID-19 tests to the American people through COVIDTests.gov and direct distribution pathways and will continue distributing millions of tests per week to long-term care facilities, food banks, health centers, and schools,” a spokesperson for ASPR said in a prepared statement sent to The Associated Press.

Mail orders for free COVID tests from the government have been paused or expanded before. Despite Friday’s suspension, it’s still possible for the program to resume again down the road — with ASPR noting that it reserves the right to use COVIDTest.gov in the future as needed.

The Biden administration first launched its free mail-order COVID tests back in January 2022. The program was most recently reopened in September of last year — and households have been eligible to order to latest round of tests since November.

The decision to suspend ordering for the program’s sixth round arrives amid lowering case rates coming out of the winter respiratory season, ASPR noted.

Last month, the Centers for Disease Control and Prevention announced that the respiratory virus season was likely past its peak following a December surge — but still urged caution.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Optimizing boosters: How COVID mRNA vaccines reshape immune memory after each dose
by Tokyo University of Science
March 8, 2024


optimizing-boosters-ho.jpg

Changes in the clonal populations of CD8+ T- cells after successive vaccinations, an ability that can be tuned for developing more effective mRNA vaccines. Credit: Satoshi Ueha/Tokyo University of Science


mRNA vaccines developed against the spike glycoprotein of severe acute respiratory syndrome type 2 coronavirus (SARS-CoV-2), displayed remarkable efficiency in combating coronavirus 19 (COVID-19). These vaccines work by triggering both cellular and humoral immune responses against the spike protein of the virus.

Cellular immunity may play a more protective role than humoral immunity to variants of concern (VOC) against SARS-CoV-2, as it targets the conserved regions of spike protein and possibly cross-reacts with other variants.

Since a single spike epitope is recognized by multiple T-cell clones, the mRNA vaccination-induced T-cell response may consist of multiple spike-reactive clones. Thus, it is important to understand the mechanism of mRNA vaccination-induced cellular immune response. However, to address this clonal-resolution analysis on T-cell responses to mRNA vaccination has not been performed yet.

To bridge this gap, a team of researchers, led by Associate Professor Satoshi Ueha, including Professor Kouji Matsushima from the Tokyo University of Science (TUS), Japan, Mr. Hiroyasu Aoki from the University of Tokyo, and Professor Toshihiro Ito from Nara Medical University, aimed to develop a kinetic profile of spike-reactive T-cell clones during repetitive mRNA vaccination.

For this, they performed a longitudinal TCR sequencing on peripheral T cells of 38 participants who had received the Pfizer vaccine from before the vaccine to after the third vaccination and then analyzed the single-cell gene expression and epitope specificity of the clonotypes.

Their findings, published in Cell Reports, revealed that while the primary T-cell response of naïve T cells generally peaked 10–18 days after the first shot, expansion of "early responders" was detected on day 7 after the first shot, suggesting that these early responders contain memory T cells against common cold coronaviruses.

They also found a "main responder" that expanded after the second shot and did not expand early after the first shot and a "third responder" that appeared and expanded only after the third shot.

By longitudinally tracking the total frequency of each response pattern, it was observed that, after the second shot, a shift among the clonotypes occurred, wherein the major population changed from early responders to main responders, suggestive of a shift in clonal dominance. A similar shift of responding clones was also observed in CD4+ T cells.

Prof. Ueha says, "We next analyzed the phenotype of main responders after the second and the third vaccination. The results showed that the main responders after the second and third shots mostly consist of effector-memory T cells (TEM), with more terminally differentiated effector memory-like phenotype after the third shot."

The researchers then examined the repertoire changes of main responders, revealing that the expansion of main responders, which occurred after the second shot, diminished following the third shot, and the clonal diversity decreased and was partially replaced by the third responders. This may potentially mean that the third vaccination selected better-responding clones.

Due to the vaccination-induced shift in immunodominance of spike epitopes, the study supports the inter-epitope shift model. In addition, there were intra-epitope shifts of vaccine-responding clonotypes within spike epitopes.

Prof. Ueha explains, "Our analysis suggests that T cells can 're-write' themselves and reshape their memory populations after successive vaccinations. This re-writability not only maintains the number of memory T cells but also maintains diversity that can respond to different variants of pathogens. Moreover, by tuning the replacement of memory cells, more effective vaccines can be developed that can also be tailored to an individual's unique immune response."

Overall, this study provides important insights into mRNA vaccine-induced T-cell responses, which will be crucial for developing next-generation vaccines for more effective and broad protection against viruses.

More information: Hiroyasu Aoki et al, CD8+ T cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance, Cell Reports (2024). DOI: 10.1016/j.celrep.2024.113887
Provided by Tokyo University of Science
 

Heliobas Disciple

TB Fanatic
(fair use applies)


REVEALED: Chinese scientist booted out of Canadian lab after MAILING Ebola virus to Wuhan linked to 'bat woman' virologist and British doctor Peter Daszak at center of Covid leak theory
By Miles Dilworth, Senior Reporter For Dailymail.Com
Published: 09:50 EST, 7 March 2024 | Updated: 11:26 EST, 7 March 2024

  • Dr Xiangguo Qiu and her husband Dr Keding Cheng were fired from a lab in Winnipeg in 2021 after they were found to have sent virus samples to China
  • The full extent of their treachery was revealed in a 600-page report released by Canadian intelligence services last week in response to cries of a cover up
  • Now, further details have emerged that put Dr Qiu at the center of 'dangerous' research at a Wuhan lab that has been accused of leaking the Covid-19 virus

A Chinese scientist who was booted out of a Canadian lab after mailing live Ebola to China is thought to have worked with the 'bat woman' virologist at the center of the Wuhan leak theory.

Dr Xiangguo Qiu was accused in a 600-page report released last week by the Canadian intelligence services of passing information onto the Wuhan Institute of Virology (WIV) without informing superiors.

Now, further details have emerged of the scientist's alleged cooperation with actors viewed as central to theories about how Covid-19 may have originated from a Chinese lab experimenting with animal viruses.

Dr Qiu and her husband Dr Keding Cheng were fired from the Canadian National Microbiology Lab in Winnipeg, Manitoba, in January 2021, after they were found to have sent lethal virus samples to China, among other serious violations.

It sparked a lengthy investigation by the Canadian Security Intelligence Service (CSIS), which released a heavily redacted report later that year.

But following cries of a cover up, hundreds of pages from the report were released to the Canadian House of Commons last Wednesday.

The documents, seen by DailyMail.com, revealed that the couple had been able to use the lab as a 'base to assist China to improve its capability to fight highly-pathogenic pathogens... and achieve brilliant results'.

The CSIS warned: 'Dr Qiu represents a very serious and credible danger to the government of Canada as a whole.

'And in particular at facilities considered high-security due to the potential for theft of dangerous materials attractive to terrorist and foreign entities that conduct espionage to infiltrate and damage the economic security of Canada.'

A section titled 'activities with the Wuhan Institute of Virology' detail the full extent of Dr Qiu's involvement in controversial animal virus research.

And a comparison of this chapter with open source records by investigative website The Bureau, suggests Dr Qiu was working directly with Chinese virologist Dr Shi Zhengli, known as 'bat woman'.

Dr Zhengli led bat research at the WIV and has been accused of conducting 'dangerous' 'gain of function' experiments, which genetically modify viruses in order to better understand the risks they pose.

She has strongly denied claims that Covid-19 leaked from her work, but last year FBI chief Christopher Wray said the virus most likely originated at a Chinese government lab.

The lax security measures at the Canadian facility exposed by the CSIS now raise fresh questions about the links between virus research being carried out in Chinese labs and western scientists.

Dr Qiu was hired by Wuhan to lead the lab's 'animal infection' project, which was to run from June 2019 to May 2021, the CSIS found.

Project design was being handled by an unnamed Chinese virologist at WIV, who had also been involved in 2015 'Gain of Function experiments with US researchers as part of a study that created a hybrid version of a bat coronavirus; one related to the virus that caused Severe Acute Respiratory Syndrome (SARS), which could jump directly from bats to humans', the documents state.

The CSIS notes that 'some scientists disapproved of the study' by the US National Institute of Health, because it was a 'new, non-natural risk' and 'provided little benefit and reveals little about the risk that the wild virus in bats poses to humans'.

Dr Zhengli and US scientists including a man named Ralph Baric completed such a study in 2015: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

Their experiment used reverse genetics to create synthetic virus strains, the same technique deployed in Wuhan's 2019 project involving Dr Qiu.

Meanwhile, a photograph of an October 2018 symposium held by WIV appears to show Dr Qiu alongside Dr Zhengli, Baric and British doctor Peter Daszak, whose charity funded WIV research.

Daszak, who runs New York-based EcoHealth Alliance, has faced questions from Congress on the federal funding it sent to the Wuhan lab and the work that was carried out there.

Dr Qiu's attendance at the symposium is confirmed by the CSIS report.

Although it does not say who Dr Qiu collaborated with, it does reveal that she provided training to others at the conference, without telling her Canadian employers.

The CSIS found Dr Qiu was enlisted by WIV to 'build a team to start a series of research topics using China's disease source as advantage'.

It also discovered that, in 2018, the doctor discussed the shipping of the Ebola virus from Canada to Wuhan.

Meanwhile, WIV secretly sponsored Qiu's applications to work surreptitiously with the People's Liberation Army in a program called Thousand Talents Plan, which was set up to pay students for participation in research to further Chinese interests.

The CSIS warned: 'Dr Qiu represents a very serious and credible danger to the government of Canada as a whole.

'And in particular at facilities considered high-security due to the potential for theft of dangerous materials attractive to terrorist and foreign entities that conduct espionage to infiltrate and damage the economic security of Canada.'

Listing violations by Dr Qiu, officials said she had provided Beijing 'with the Ebola genetic sequence, which opened a door of convenience for China'.

Dr Qiu and her scientist husband are now nowhere to be seen, although it is thought they have moved back to China.

They have not been reachable for comment and the newly-released CSIS documents did not include a statement from the couple.

But they did reveal that Dr Qiu repeatedly claimed to investigators that she was not aware that she had broken any security rules.

She blamed the health agency for not fully explaining procedures and frequently tried to mislead investigators until confronted by contradictory evidence, according to the report.

The extent of Dr Qiu's personal contact with Dr Zhengli is unclear.

Many scientists have argued that there is no evidence that Covid-19 leaked from a Chinese lab and the origin of the pandemic is still hotly disputed.

In February last year, the US Energy Department joined the FBI in its assessment that the virus most likely spread via a mishap at a Chinese laborator.

But four other agencies, along with a national intelligence panel, still judge that it was likely the result of a natural transmission, and two are undecided.

Daszak, who lives with his immunologist wife Janet Cottingham in a five-bed, five-bath home in an affluent town in Rockland County, New York, however, has faced accusations that he 'bullied' other scientists into signing off on a letter to a prestigious medical journal that removed blame for Covid-19 on the Wuhan Institute of Virology.

He declined to comment on the allegations when confronted by DailyMail.com at his home in June 2021.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Trump ‘Clearly Hasn’t Learned From His COVID-Era Mistakes,’ RFK Jr. Says
Former president’s praise of swiftly bringing the COVID vaccine to market draws the ire of Robert F. Kennedy Jr. during State of the Union address.

By Jeff Louderback
3/8/2024

President Joe Biden claimed that COVID vaccines are now helping cancer patients during his State of the Union address on March 7, but it was a response on Truth Social from former President Donald Trump that drew the ire of independent presidential candidate Robert F. Kennedy Jr.

During the address, President Biden said: “The pandemic no longer controls our lives. The vaccines that saved us from COVID are now being used to help beat cancer, turning setback into comeback. That’s what America does.”

President Trump wrote: “The Pandemic no longer controls our lives. The VACCINES that saved us from COVID are now being used to help beat cancer—turning setback into comeback. YOU’RE WELCOME JOE. NINE-MONTH APPROVAL TIME VS. 12 YEARS THAT IT WOULD HAVE TAKEN YOU.”

An outspoken critic of President Trump’s COVID response, and the Operation Warp Speed program that escalated the availability of COVID vaccines, Mr. Kennedy said on X, formerly known as Twitter, that “Donald Trump clearly hasn’t learned from his COVID-era mistakes.”

“He fails to recognize how ineffective his warp speed vaccine is as the ninth shot is being recommended to seniors. Even more troubling is the documented harm being caused by the shot to so many innocent children and adults who are suffering myocarditis, pericarditis, and brain inflammation,” Mr. Kennedy remarked.

“This has been confirmed by a CDC-funded study of 99 million people. Instead of bragging about its speedy approval, we should be honestly and transparently debating the abundant evidence that this vaccine may have caused more harm than good.

“I look forward to debating both Trump and Biden on Sept. 16 in San Marcos, Texas.”

Mr. Kennedy announced in April 2023 that he would challenge President Biden for the 2024 Democratic Party presidential nomination before declaring his run as an independent last October, claiming that the Democrat National Committee was “rigging the primary.”

Since the early stages of his campaign, Mr. Kennedy has generated more support than pundits expected from conservatives, moderates, and independents resulting in speculation that he could take votes away from President Trump.

Many Republicans continue to seek a reckoning over the government-imposed pandemic lockdowns and vaccine mandates.

President Trump’s defense of Operation Warp Speed, the program he rolled out in May 2020 to spur the development and distribution of COVID-19 vaccines amid the pandemic, remains a sticking point for some of his supporters.

Operation Warp Speed featured a partnership between the government, the military, and the private sector, with the government paying for millions of vaccine doses to be produced.
President Trump released a statement in March 2021 saying: “I hope everyone remembers when they’re getting the COVID-19 Vaccine, that if I wasn’t President, you wouldn’t be getting that beautiful ‘shot’ for 5 years, at best, and probably wouldn’t be getting it at all. I hope everyone remembers!”

President Trump said about the COVID-19 vaccine in an interview on Fox News in March 2021: “It works incredibly well. Ninety-five percent, maybe even more than that. I would recommend it, and I would recommend it to a lot of people that don’t want to get it and a lot of those people voted for me, frankly.

“But again, we have our freedoms and we have to live by that and I agree with that also. But it’s a great vaccine, it’s a safe vaccine, and it’s something that works.”

On many occasions, President Trump has said that he is not in favor of vaccine mandates.

An environmental attorney, Mr. Kennedy founded Children’s Health Defense, a nonprofit that aims to end childhood health epidemics by promoting vaccine safeguards, among other initiatives.

Last year, Mr. Kennedy told podcaster Joe Rogan that ivermectin was suppressed by the FDA so that the COVID-19 vaccines could be granted emergency use authorization.

He has criticized Big Pharma, vaccine safety, and government mandates for years.

Since launching his presidential campaign, Mr. Kennedy has made his stances on the COVID-19 vaccines, and vaccines in general, a frequent talking point.

“I would argue that the science is very clear right now that they [vaccines] caused a lot more problems than they averted,” Mr. Kennedy said on Piers Morgan Uncensored last April.

“And if you look at the countries that did not vaccinate, they had the lowest death rates, they had the lowest COVID and infection rates.”

Additional data show a “direct correlation” between excess deaths and high vaccination rates in developed countries, he said.

President Trump and Mr. Kennedy have similar views on topics like protecting the U.S.-Mexico border and ending the Russia-Ukraine war.

COVID-19 is the topic where Mr. Kennedy and President Trump seem to differ the most.

Former President Donald Trump intended to “drain the swamp” when he took office in 2017, but he was “intimidated by bureaucrats” at federal agencies and did not accomplish that objective, Mr. Kennedy said on Feb. 5.

Speaking at a voter rally in Tucson, where he collected signatures to get on the Arizona ballot, the independent presidential candidate said President Trump was “earnest” when he vowed to “drain the swamp,” but it was “business as usual” during his term.

John Bolton, who President Trump appointed as a national security adviser, is “the template for a swamp creature,” Mr. Kennedy said.

Scott Gottlieb, who President Trump named to run the FDA, “was Pfizer’s business partner” and eventually returned to Pfizer, Mr. Kennedy said.

Mr. Kennedy said that President Trump had more lobbyists running federal agencies than any president in U.S. history.

“You can’t reform them when you’ve got the swamp creatures running them, and I’m not going to do that. I’m going to do something different,” Mr. Kennedy said.

During the COVID-19 pandemic, President Trump “did not ask the questions that he should have,” he believes.

President Trump “knew that lockdowns were wrong” and then “agreed to lockdowns,” Mr. Kennedy said.

He also “knew that hydroxychloroquine worked, he said it,” Mr. Kennedy explained, adding that he was eventually “rolled over” by Dr. Anthony Fauci and his advisers.

MaryJo Perry, a longtime advocate for vaccine choice and a Trump supporter, thinks votes will be at a premium come Election Day, particularly because the independent and third-party field is becoming more competitive.

Ms. Perry, president of Mississippi Parents for Vaccine Rights, believes advocates for medical freedom could determine who is ultimately president.

She believes that Mr. Kennedy is “pulling votes from Trump” because of the former president’s stance on the vaccines.

“People care about medical freedom. It’s an important issue here in Mississippi, and across the country,” Ms. Perry told The Epoch Times.

“Trump should admit he was wrong about Operation Warp Speed and that COVID vaccines have been dangerous. That would make a difference among people he has offended.”

President Trump won’t lose enough votes to Mr. Kennedy about Operation Warp Speed and COVID vaccines to have a significant impact on the election, Ohio Republican strategist Wes Farno told The Epoch Times.

President Trump won in Ohio by eight percentage points in both 2016 and 2020. The Ohio Republican Party endorsed President Trump for the nomination in 2024.

“The positives of a Trump presidency far outweigh the negatives,” Mr. Farno said. “People are more concerned about their wallet and the economy.

“They are asking themselves if they were better off during President Trump’s term compared to since President Biden took office. The answer to that question is obvious because many Americans are struggling to afford groceries, gas, mortgages, and rent payments.

“America needs President Trump.”

Multiple national polls back Mr. Farno’s view.

As of March 6, the RealClearPolitics average of polls indicates that President Trump has 41.8 percent support in a five-way race that includes President Biden (38.4 percent), Mr. Kennedy (12.7 percent), independent Cornel West (2.6 percent), and Green Party nominee Jill Stein (1.7 percent).

A Pew Research Center study conducted among 10,133 U.S. adults from Feb. 7 to Feb. 11 showed that Democrats and Democrat-leaning independents (42 percent) are more likely than Republicans and GOP-leaning independents (15 percent) to say they have received an updated COVID vaccine.

The poll also reported that just 28 percent of adults say they have received the updated COVID inoculation.

The peer-reviewed multinational study of more than 99 million vaccinated people that Mr. Kennedy referenced in his X post on March 7 was published in the Vaccine journal on Feb. 12.

It aimed to evaluate the risk of 13 adverse events of special interest (AESI) following COVID-19 vaccination. The AESIs spanned three categories—neurological, hematologic (blood), and cardiovascular.

The study reviewed data collected from more than 99 million vaccinated people from eight nations—Argentina, Australia, Canada, Denmark, Finland, France, New Zealand, and Scotland—looking at risks up to 42 days after getting the shots.

Three vaccines—Pfizer and Moderna’s mRNA vaccines as well as AstraZeneca’s viral vector jab—were examined in the study.

Researchers found higher-than-expected cases that they deemed met the threshold to be potential safety signals for multiple AESIs, including for Guillain-Barre syndrome (GBS), cerebral venous sinus thrombosis (CVST), myocarditis, and pericarditis.

A safety signal refers to information that could suggest a potential risk or harm that may be associated with a medical product.

The study identified higher incidences of neurological, cardiovascular, and blood disorder complications than what the researchers expected.

President Trump’s role in Operation Warp Speed, and his continued praise of the COVID vaccine, remains a concern for some voters, including those who still support him.

Krista Cobb is a 40-year-old mother in western Ohio. She voted for President Trump in 2020 and said she would cast her vote for him this November, but she was stunned when she saw his response to President Biden about the COVID-19 vaccine during the State of the Union address.

“I love President Trump and support his policies, but at this point, he has to know they [advisers and health officials] lied about the shot,” Ms. Cobb told The Epoch Times.

“If he continues to promote it, especially after all of the hearings they’ve had about it in Congress, the side effects, and cover-ups on Capitol Hill, at what point does he become the same as the people who have lied?” Ms. Cobb added.

“I think he should distance himself from talk about Operation Warp Speed and even admit that he was wrong—that the vaccines have not had the impact he was told they would have. If he did that, people would respect him even more.”
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Big Pharma Profits Over Lives: Dr. Sabine Hazan Exposes COVID Cartel’s Suppression of Essential Gut Health Data
By Tracy Beanz & Michelle Edwards
Updated 5:03 AM EST, Fri March 8, 2024

Distinguished gastroenterologist Dr. Sabine Hazan spoke at U.S. Senator Ron Johnson’s (R-WI) recent roundtable discussion titled “Federal Health Agencies and the COVID Cartel: What Are They Hiding?” Listed as a speaker to examine “Corruption of Medical Research and Federal Health Agencies,” Dr. Hazen shared eye-opening details regarding how her groundbreaking findings on how COVID-19 vaccines wreaked havoc on the gut microbiome were censured and silenced. Likewise, she shared how her research emphasizing the efficacy of specific treatments like hydroxychloroquine, azithromycin, and Ivermectin against COVID-19 was also swept under the rug.

Dr. Hazan explained that the microbiome—the microbes in our gut—is essentially our immunity, and when studied, it tells the story of COVID-19. Certainly seems like something worth knowing. A practicing gastroenterologist for the last three decades, Dr. Hazan dove right in when the pandemic hit. Her laboratory, Progenabiome, was the first to document the entire sequence of SARS-CoV-2 in the stools as opposed to the PCR test. She pointed out that microbiome research through the stools presents the whole picture of the virus instead of the PCR, which is merely a tiny piece of the virus. Again, this information appears super critical.

This tik tok had close to $1 million views last night and over 25k retweets and, in 24 hours, was pulled down @JanJekielek Do we still believe this is about a virus? They who want to control don’t want you to make discoveries. I tried to repost it, and it says “ under review” …… pic.twitter.com/TQpSY2r3O1
— sabine hazan md (@SabinehazanMD) March 26, 2023

Right off the bat, Dr. Hazan and her lab discovered that the virus lingered in the stool for up to 45 days. That finding seems pretty significant, yet Hazan explained it took six months to publish the discoveries “at a time where everybody needed to know that it was in your stools.” Her lab also showed that COVID-19 in the stools was killed by hydroxychloroquine and azithromycin, but the drugs also killed the gut microbiome in the process. Thus, she added vitamins C, D, and zinc to protocols using those drugs. She submitted her studies and protocol information to the FDA and put them into clinicaltrials.gov “in full transparency to help doctors more effectively treat COVID.”

On April 2, 2020, no doubt due to her incredible knowledge of the data at hand, the FDA gave Hazan an exempt letter informing her that she did not need to do a clinical trial on hydroxychloroquine, Z-Pak, vitamins C, D, and zinc as a COVID treatment or for hydroxychloroquine, vitamins C, D, and zinc to prevent COVID. Not so fast, Dr. Hazan’s exemption was denied a short month later, with the FDA informing her she must do full-on clinical trials. Underscoring how her critical work was controlled and censored, Hazan told the roundtable:

“By then, the media created fear around hydroxychloroquine. It was impossible to recruit. This drug was safely given for years for arthritis and lupus with no problems. My clinical trials companies were also banned and censored from advertising on Facebook, Instagram, and Twitter. Remember, I do clinical trials for a living, and never, as a clinical trial doctor, have I not been able to advertise to recruit for a trial on social media.”
And, of course, as predicted, @YouTube put misinformation on my video of my talk at the Senate. @US_FDA @FBI, pay attention. “Interference with research affects all of us. This should not be political. Science is a story that evolves, a series of experiments that allow us to…
— sabine hazan md (@SabinehazanMD) March 5, 2024

Why wouldn’t the FDA immediately want to know and share with the American people effective treatments for COVID-19? That question alone has shattered many Americans’ trust in the taxpayer-funded agency tasked with protecting the public’s health. The glaringly obvious and sinister motivation made Big Pharma billions and must be further exposed. Clearly—if a safe and effective treatment for COVID-19 had already existed, the FDA would have had no power to issue an emergency use authorization for the experimental, gene-damaging mRNA COVID-19 jabs once they were ready to go. That would’ve meant no vaccine mandates and less justification for the 24/7 mainstream media broadcast of fear-based propaganda.

Indeed, Dr. Hazan’s research would have made COVID-19 less threatening. Despite the setbacks, Dr. Hazan, who has conducted over 200 clinical trials for pharmaceutical companies, including vaccine studies, persevered and continued to collect stool samples. In a significant discovery, she noticed that patients with severe COVID-19 were missing a critical microbe for immunity called Bifidobacteria, vital in mitigating COVID-19 severity. Importantly, her finding suggested a clear link between the absence of Bifidobacteria and severe COVID-19 outcomes. This discovery undoubtedly implicates a potential mechanism for further research and intervention. But her work was ignored. Expanding on the critical role of Bifidobacteria and efforts to keep it quiet, Dr. Hazan shared:

“[Bifidobacteria] represents your trillion-dollar industry of probiotics. In fact, when you turn the bottle and see the ingredients, it says Bifidobacteria. It is present in newborns. This [explains] why your newborn did not have a problem with COVID-19 from the beginning. It is absent in older people—the process of aging is loss of Bifidobacteria.
We published a paper, the Lost Microbes of COVID-19. It took eight months to publish. If you follow the Bifidobacteria like I do, you will notice, and we did notice, that vitamin C actually increases Bifidobacteria, [which] is why vitamin C is important when taking care of viruses. [We’ve] all experienced taking vitamin C for a cold.”

Like vitamin C, Dr. Hazan and her team noticed that Ivermectin also increased the Bifidobacteria within 24 hours of taking it. “Why Ivermectin?” she asked, explaining that when you examine what Ivermectin is, you understand it is a fermented product of a bacteria similar to Bifidobacteria. In fact, she explained, they are “in the same continent of microbes, like brothers and sisters in the microbiome.” That’s very interesting! Yet, with all the controversy and censorship surrounding Ivermectin during the pandemic, Dr. Hazan said she knew it would be too controversial to flat-out publish. So instead, she published a hypothesis stating that “what I was observing on the frontline treating patients with COVID-19 was that their oxygen saturation was increasing from Ivermectin, maybe because Ivermectin increased Bifidobacteria.” Dr. Hazan shared with the panel that even her hypothesis was canceled, noting:

“The hypothesis on Ivermectin was the most read hypothesis in the pandemic and it was retracted after eight months of being up. When we cannot make a hypothesis, this is not science.”

In December 2020, as the dangerous COVID-19 jabs became a reality, in addition to treating patients with COVID-19, Dr. Hazan began collecting stool samples from patients at home who went to the hospital. She asked them if she could get stool samples before and after they got the COVID-19 jab since nothing was known about how the new mRNA technology would affect the microbiome. Considering the power of the gut-brain connection, having this information seems paramount. It should be no shock that Dr. Hazan found that the mRNA vaccines killed the Bifidobacteria. Noting that if doctors can’t publish data, they cannot find solutions to fix problems, she shared:

“I knew I would never be able to publish this because it goes against the narrative. So, I submitted it to my college, the American College of Gastroenterology, and presented it in October 2022. The abstract won a research award, beating 6,000 abstracts from academic centers like Harvard, Mayo Clinic, and MD Anderson. [My] abstract got the attention of 18,000 GI doctors who all of a sudden started realizing, ‘maybe killing bifidobacteria is why I got COVID after my vaccine to begin with.’
Worse than that, another abstract we presented was the persistent damage of Bifidobacteria from the vaccine. What is going on here that the vaccine continues to kill the Bifidobacteria? At the same time, we presented a link between loss of Bifidobacteria and Crohn’s disease, loss of Bifidobacteria in Lyme disease, and loss of Bifidobacteria in an invasive cancer.
It is nearly impossible to publish data that goes against the national public health narrative.”

Wrapping up, Dr. Hazan conveyed that before COVID-19, she performed clinical trials for Big Pharma, including vaccine studies. Why not with this experimental gene-damaging “vaccine” that was forced upon humanity? Some of the drugs she tested never made it to the market because they killed people. She remarked that in clinical trials, doctors follow guidelines that allow the industry to provide safe drugs. Yet, these guidelines were not observed during the pandemic, “and because of that, everyone is affected.” Disappointed, she noted that science is a story that evolves, and COVID should have been a moment when humanity joined forces with doctors needing to come together. Experiments allow us to see medicine and give hope to skeptical patients, challenging the current state of knowledge. Dr. Hazen closed, remarking, “Having an open mind must be allowed if we have any hope of moving science forward. What I saw in this pandemic was not science.”

Following her speech, which should leave all Americans feeling frustrated, angry, and hoodwinked, Sen. Johnson asked Dr. Hazan to name who she thinks sabotaged her research, to which she aptly replied:

“It used to be that pharmaceutical companies were working with the doctors. Now, unfortunately, pharmaceutical companies are captured by the price of their stock. Venture capitalists own the pharmaceutical companies, they own the clinical research organizations, they own the site, and they own the institutional review board. They own the advertising and the marketing. They influence through the media. And so, unfortunately – it’s a loaded question – but it’s a big market. And what we saw during this pandemic was the price of the stock mattered more than the price of a life.”



VIDEO REFERRED TO IN ARTICLE:


View: https://www.youtube.com/watch?v=iy5GxZCnrYQ
COVID Cartel Round Table - Dr. Sabine Hazan Presentation
Let's Talk Sh!t - The Podcast - From ProgenaBiome
Feb 27, 2024 DISTRICT OF COLUMBIA
10 min 5 sec


SEE ALSO:


IS THE COVID VACCINE KILLING YOUR GUT BIOME - DR SABINE HAZAN ON THE HIGHWIRE WITH DEL BIGTREE
10 months ago
1 hr 08 min 13 sec
 
Last edited:

Heliobas Disciple

TB Fanatic

(fair use applies)


Sao Paulo-Brazil Records 54 Percent Increase Of COVID-19 Deaths And 85 Percent Increase In Infections
Nikhil Prasad Fact checked by:Thailand Medical News Team
Mar 09, 2024

In the heart of Brazil, the state of Sao Paulo is facing an ominous resurgence of COVID-19, marked by an unprecedented 85% increase in infections and a staggering 54% surge in deaths within a mere 15 days. This alarming trend, disclosed by the Info Tracker platform, is indicative of a renewed wave of the virus that poses significant challenges to public health infrastructure. In this COVID-19 News report, we delve into the various factors contributing to this surge, its impact on the populace, and the responses implemented to mitigate its effects.


Unveiling the Data
The Info Tracker platform, dedicated to monitoring the evolution of the COVID-19 pandemic in Brazil, has brought forth disconcerting data.


Sao Paulo witnessed an 85% spike in cases, soaring from 7,000 to 13,000 in a fortnight. The gravity of the situation is further underscored by a 54% increase in fatalities, escalating from 57 to 88 victims within the same period. Wallace Casaca, coordinator of the SP Covid-19 Info Tracker platform and a researcher at Unesp and USP, expresses deep concern about the intersection of this uncontrolled COVID-19 spread with a surge in dengue cases and other respiratory infections, placing immense pressure on healthcare systems and service centers.

Various COVID-19 News and Dengue news coverages are already warning that hospitals and clinics across Brazil are inundated with sick individuals, either from Dengue, COVID-19, Flu, RSV and even Malaria, Measles and Cholera.


https://www.thailandmedical.news/ne...s-jn-2-5-and-jn-1-7-variants-possibly-at-play

https://www.thailandmedical.news/ne...e-and-214-deaths-for-first-two-months-of-2024


New Wave Details
The new wave gripping São Paulo is fueled by a rapid dissemination of new Omicron subvariants, with JN.1 gaining prominence. The impact of recent mass-displacement events, including the Bolsonarista demonstration on Avenida Paulista and the exuberant carnival celebrations, cannot be overstated. Casaca emphasizes that these large gatherings, particularly the Bolsonarista event on January 25th, with a staggering attendance of 185,000 people from various parts of Brazil, have likely acted as super-spreader events.


Comparative Analysis
Comparing the epidemiological data from the current week with the first week of 2024 reveals a distressing 377% increase in COVID-19 cases, presenting a dire picture of the current surge. The resurgence has compelled Sao Paulo residents to revert to wearing masks, especially in high-traffic environments and on public transport. As this wave gains momentum, the trend is not exclusive to Sao Paulo; other parts of the world, including the United States, are grappling with similar challenges.


Government Response and Recommendations
Acknowledging the critical situation, the state health department issued a note, asserting its constant monitoring of the epidemiological scenario, including the proliferation of variants. Vaccination against COVID-19 is strongly emphasized, with particular emphasis on booster and bivalent doses. In addition to immunization efforts, the department underscores the enduring importance of well-known preventive measures: hand hygiene with soap and water or alcohol gel and respiratory etiquette, emphasizing the necessity of covering the nose and mouth when coughing or sneezing.


Campinas Faces a Surge in Deaths
Zooming in on Campinas, a city in Sao Paulo, the escalating COVID-19 cases have led to the highest number of deaths in one week since December 2022. The week of February 25th recorded 11 deaths, reflecting an upward trajectory in infections post-carnival and back-to-school periods. The positivity rate of COVID-19 tests has exceeded 40%, reaching 43.9%, reminiscent of the peak of the pandemic. Dr. Elda Motta from the Department of Health Surveillance assures that there is no indication of an increase in the severity of the disease. However, the observed growth in cases emphasizes the need for fundamental care, ranging from vaccination to stringent hand hygiene.


Challenges Faced by Campinas
Amid the escalating cases and deaths, Campinas confronts numerous challenges. A critical shortage of tests for diagnosing COVID-19 in the public network has raised concerns. Efforts are underway to expedite deliveries and avert potential shortages. Additionally, a low supply of the bivalent vaccine against the disease, with approximately 20% of Health Centers experiencing unavailability, compounds the challenges faced by the city. The city's Health Department attributes these shortages to the delayed and insufficient deliveries from the State.


Vaccination Coverage and Variants
According to the vaccinometer provided by the government of Sao Paulo, 89.87% of the state's population has completed the vaccination schedule. However, coverage is notably lower among children, with only 50.33% having a complete vaccination schedule in the age range from six months to 11 years. The new wave, fueled by variants like JN.1, is not isolated to Sao Paulo alone; it has also reached other parts of the country and even the northern hemisphere, as evidenced by the surge in cases in New York, United States.


Insight into the JN.1 Variant:
The JN.1 variant group, a descendant of the Pirola variant (BA.2.86), has gained prominence, being responsible for 60% of COVID-19 cases in Brazil in January 2024. JN.1 boasts over 30 mutations compared to the XBB.1.5 variant, which was dominant for most of 2023. Researchers warn that JN.1's additional mutations can impact its ability to evade protective immunity conferred by vaccines and previous infections.


Conclusion
The resurgence of COVID-19 in Sao Paulo, coupled with a surge in deaths in Campinas, paints a grim picture of the ongoing challenges posed by the pandemic. The rapid spread of new Omicron subvariants and mass-displacement events are identified as major contributors to the alarming increase in cases and deaths. Vaccination, alongside known preventive measures, remains pivotal in curbing the virus. Sao Paulo's situation serves as a stark reminder of the collective efforts, vigilance, and swift responses required to navigate the ongoing health crisis successfully. As the world confronts new waves and variants, global cooperation and adherence to public health guidelines become paramount in ensuring the well-being of communities worldwide.
 

Heliobas Disciple

TB Fanatic
View: https://www.youtube.com/watch?v=ySMqoy0Nc00
Could Amyloid Fibrin Clots become Huge Embalmers' Clots?
Vejon Health
Streamed live March 9, 2024
30 min 6 sec

Continuing to explore with Professor Douglas Kell, the mechanics of clotting and the spike protein, to help understand the unusual pattern of clots occurring across the world.

Recently a whistleblower from a Cath-lab showed images of abnormal clots being pulled from patients in hospital.

Watch full video here:

Professor Douglas Bruce Kell CBE FRSB FLSW is a British biochemist and Research Professor of Systems Biology in the Institute of Systems, Molecular and Integrative Biology at the University of Liverpool, and a Co-founder of Epoch Biodesign Ltd.

Follow his long covid work here:

Professor Kell was appointed Commander of the Order of the British Empire (CBE) in the 2014 New Year Honours, for services to science and research.[1] Kell is also a Fellow of the Learned Society of Wales (FLSW), a Fellow of the Royal Society of Biology (FRSB) and a Fellow of the American Association for the Advancement of Science (FAAS).
 

Heliobas Disciple

TB Fanatic
(fair use applies)


All major Covid vaccines worldwide were once declared 100% effective, but zero actually worked
How to lie with statistics.

Jordan Schachtel
Mar 6, 2024


40 vaccine candidates worldwide were approved by governments to confer high levels of protection against Covid-19, but none of them actually worked.

So how exactly did this happen?

As we approach the Fourth Year To Slow The Spread of the rebranded flu, it’s time to start examining the methods through which the world was fooled into conforming to and complying with the global hysteria that was the Covid-19 era.

As you’ll see below, the Covid shots, which served as the biggest windfall for the pharmaceutical industry in modern history, were advertised as something akin to the cure to Covid-19.

During the “race to the cure,” there was no discussion of the likelihood of endless annual or seasonal boosters. When you dip into the archives, no such warnings were delivered, nor was any speculation or conversation about future shots allowed, for fear of being labeled a “conspiracy theorist.”

Pharmaceutical giants and governments around the world promised that just one or perhaps two shots conferred what was commonly understood as *immunity* to Covid-19.

Now it’s time to go into the archives:



AstraZeneca: 100% effective





Pfizer: 100% effective





Bill Gates secured hundreds of millions in profits from mRNA stock sales before suddenly changing tune on vaccine technology

Jordan Schachtel
January 31, 2023
Read full story



Moderna: 100% effective against severe disease





Johnson & Johnson: 100% effective against severe disease





Sinopharm (China): 100% effective against severe disease





Sputnik (Russia): 100% effective against severe disease





Novavax (USA): 100% effective and moderate and severe disease





Covaxin (India): 100% effective




In the end, those of us who decided to take the shot got scammed, no matter where we lived. Billions of people lined up to get their advertised Covid cures. And it didn’t matter whether they were RNA vaccines, viral vector shots, subunit vaxxes, or inactivated viral shots. All of them were advertised as the ultimate form of “protection” against Covid-19, preventing its recepients from having a fatal case of the Wuhan sniffles.

But what began as the cure has become a nine dose fiasco:

Dose number NINE: CDC panel green lights yet another Covid mRNA shot
Jordan Schachtel
Feb 29
Read full story


In the United States, the deception begins decades ago, via the fusion of government and Big Pharma. For the likes of Pfizer and Moderna, they need not worry about repercussions, because the government gave them both hundreds of billions of dollars in taxpayer money, and blanket legal immunity from citizens harmed by the shots.

Beyond the borders of the United States, the race to the vaccine became something of a geopolitical prestige contest, with competing parties continually raising expectations to the point that everyone had decided that they possessed a “100% effective” miracle cure.





Due to a combination of broken incentives and corrupt/deceitful governance, the powers that be decided to deploy progressively shoddier studies to declare that they possessed the cure to the coronavirus.

But none of them actually did.

Nobody even came close.

In 2024, there is still no cure or proven “vaccine” for any respiratory disease.

It truly serves as the ultimate lesson in how to lie with statistics, and how to never let a crisis go to waste.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Scientists Discover New Class of Antivirals That Work Against COVID

By University of Alberta
March 10, 2024

According to the lead researcher, “We need these drugs to prevent or treat future viral outbreaks.”

A research team at the University of Alberta has discovered a new class of drugs with the potential to prevent or treat infections in a future viral outbreak.

In the paper, published in the journal Nature, the team reports that SARS-CoV-2 — the virus that causes COVID-19 — activates a pathway in cells that stops the production of peroxisomes and interferon, key parts of the normal immune response. The team successfully tested a new class of antiviral drugs that stimulate interferon production to reverse that effect.

Tom Hobman, lead author and professor of cell biology in the Faculty of Medicine and Dentistry, explains interferon stops infected cells from producing more virus by shutting down the infected cell, which often results in cell death, and then acts on the surrounding cells to prevent them from being infected.

The paper builds on his team’s earlier research that showed how HIV has evolved to activate the Wnt/ß-catenin signaling pathway in cells as a way to stop the body from producing peroxisomes, which trigger interferon production. The researchers thought SARS-CoV-2, another RNA virus, would act in a similar fashion to counteract the body’s antiviral response.


Promising Results from Drug Testing

For the study, the team tried 40 existing drugs that target the Wnt/ß-catenin signaling pathway. Most were originally developed and tested for treating cancer, which often responds to boosted interferon production. Three of the drugs significantly reduced the amount of virus found in the lungs, and one of the drugs was also effective at reducing inflammation and other clinical symptoms in mice.

“We saw, in some cases, a 10,000-fold reduction in the amount of virus produced in a test tube, and when we went into a mouse model, the drugs prevented severe weight loss and the mice recovered much quicker,” said Hobman.

During a viral outbreak, people who might have been exposed or who have already developed early symptoms would take a four- or five-day course to prime their peroxisome levels and limit the severity and spread of the disease.

“The beauty of this approach is that in the absence of viral infection, there’s no interferon produced,” Hobman says. “We see these drugs potentially serving as first-line drugs against emerging viruses.”

Reference: “The Wnt/ß-catenin pathway is important for replication of SARS-CoV-2 and other pathogenic RNA viruses” by Zaikun Xu, Mohamed Elaish, Cheung Pang Wong, Bardes B. Hassan, Joaquin Lopez-Orozco, Alberto Felix-Lopez, Natacha S. Ogando, Les Nagata, Lara K. Mahal, Anil Kumar, Joyce A. Wilson, Ryan Noyce, Irv Mayers, Christopher Power, David Evans and Tom C. Hobman, 21 February 2024, npj Viruses.
DOI: 10.1038/s44298-024-00018-4
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Japanese scientists demonstrate mRNA vaccine-induced refocusing of effector memory T cells but don’t seem to bother to demonstrate their functionality…..
Geert Vanden Bossche

Mar 10, 2024

I read the following publication: “CD8+T cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance” (cell.com/action/showPdf?pii=S2211-1247%2824%2900215-8).

This study is focusing on the characterization of mRNA vaccine-skewed T cell clonotypes and the dynamics of the shift in immunodominance in spike (S) epitopes following repeated mRNA vaccination.

These scientists have conducted sophisticated molecular characterization studies on T cell clones induced or recalled by mRNA vaccines. Their findings simply confirm what I have been telling all along: that mRNA vaccines initiate immune refocusing of the Covid-19 (C-19) vaccinee’s immune system. Successive SARS-CoV-2 (SC-2) mRNA vaccinations have already been shown to shift humoral immunity to subneutralizing and eventually IgG4 Ab responses, which promote viral immune escape and contribute to immunopathology, respectively (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222767/; The Inescapable Immune Escape Pandemic : see chapters 1.2.7. and 1.2.9.; Durability of immune responses to mRNA booster vaccination against COVID-19). The current study is now showing that such repeated mRNA injections also cause a shift in clonal dominance of T effector memory cells between S epitopes. As low-affinity anti-S antibodies (Abs) induced at an early stage of mRNA transfection of host cells enable immune refocusing (The Inescapable Immune Escape Pandemic : see chapters 1.2.2., 7.1.,11.2.), it is not surprising that these Japanese researchers established that mRNA vaccine-induced anti-RBD[1] Ab titers were positively correlated with the shift in clonal dominance (i.e., immune refocusing) of CD8+ and CD4+ T cell responses. While skewing of T cell clonotypes and concomitant inter- or intra-epitope shifts in clonal dominance of anti-S T cells after the second and third injection of mRNA-based C-19 mRNA-based vaccines may lead to increased T cell diversity, the authors didn’t seem to bother about investigating the functionality of the re-oriented T cell responses. This omission is a significant flaw as enhanced TCR[2] diversity does not necessarily imply enhanced functional effectiveness of these T cells.

It is well known that vaccines promoting immune responsiveness to a more diverse spectrum of pathogen variants may drive large-scale immune escape if the functional capacity of the induced immune effector cells is suboptimal, meaning they are unable to fully eliminate the pathogen. This particularly applies when such vaccines are used in mass vaccination programs. It is, indeed, astonishing to a seasoned vaccinologist how these researchers can even suggest that the results from their research, pointing to ‘re-writability’ of T cell immunological memory, may enable mRNA vaccine-induced T cells ‘to effectively generate responses to variant strains of the virus’…… unless they mean that ‘effectively’ does not relate to the functionality of the immune responses generated! In summarizing this publication, Tokyo University of Science misleads the scientific community by erroneously concluding that the provided insights pertaining to mRNA vaccine-induced T-cell responses ‘will be crucial for developing next-generation vaccines for more effective and broad protection against viruses’ (Optimizing Boosters: How COVID mRNA Vaccines Reshape Immune Memory After Each Dose | Tokyo University of Science).


Why are their conclusions misleading?

The effectiveness of vaccine-induced T cell (Tc) responses significantly relies on their functionality rather than solely on the magnitude of these immune responses towards viral Tc epitopes. Failure to analyze the cytolytic capacity of vaccine-induced Tc responses, including shifted or refocused Tc responses, inevitably leads to erroneous interpretations and misunderstandings regarding the significance of these Tc responses, as well as the implications of successive mRNA vaccinations.

Every seasoned vaccinologist would indeed ask the following relevant questions:

- Why did these researchers not investigate the functional capacity of the shifted T cell repertoire to kill virus-infected cells?
In the current context of sustained viral transmission, no single T effector memory cell is relevant to individual or public health unless it can kill virus-infected cells. The expansion and clonal diversification of non-cytolytic T cells, for example, has repeatedly been shown to facilitate viral immune escape and immune pathology rather than eliminate the infection. This omission represents a significant limitation of the study that the authors failed to acknowledge. Characterizing the diversity of the TCR repertoire without exploring the role of targeted epitopes in the viral life cycle and their susceptibility to functional immune responses does not contribute to a comprehensive understanding of elicited T cell responses.
- Why did the researchers not conduct epitope mapping of the skewed T cell clonotypes to examine and monitor a potential association between shifted Tc target epitopes and the mutations observed in dominantly circulating variants within highly C-19-vaccinated populations?

- Why didn’t they extend their analysis to real-life conditions, where C-19-vaccinated individuals are exposed to vaccine breakthrough infections (VBTIs), thus further influencing the evolutionary dynamics of immune refocusing?

If they had pursued this inquiry, they would undoubtedly have found that shifts in clonal dominance of T cells targeting viral proteins other than the S protein are now driving the emergence of immune escape mutations that bolster viral replication and production of viral offspring. (Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants).

How many more years will it take before vaccine researchers realize that vaccine-induced immune diversity and the magnitude of immune effector recall responses do not necessarily equate to functional effectiveness of these immune effector cells?

Is it that difficult to comprehend that whenever the functional capacity of immune effectors fails to neutralize free-circulating virus, or otherwise inhibit its infectivity, or to kill virus-infected host cells, the immune response will inevitably lead to immune escape? Until this fundamental understanding permeates the scientific community, we remain at risk of wasting significant amounts of our precious time deciphering results from sophisticated analyses that only remain accessible to researchers entrenched in their respective expertise, yet detached from the real-life issues and challenges posed by the current ‘immune escape’ pandemic.

Conclusions that appear straightforward and rigorous but stem from complex and elaborate exercises in ‘molecular stamp collection’ should always raise suspicion as enhanced complexity only implies enhanced credibility in the kingdom of the blind (where one-eyed is king….).

In summary, my conclusions are as follows:

The results from this study merely confirm the detrimental impact of mRNA vaccines in failing to elicit a highly functional immune response targeted at the specific epitope(s) responsible for viral infectiousness. As mRNA vaccines, akin to VBTIs, steer immune responses away from these epitopes, mass vaccination inducing adaptive immune cells against vulnerable viral proteins will inevitably result in functional degradation of the immune response.

I have consistently emphasized that the intrinsic property of mRNA vaccines to trigger immune refocusing, as corroborated by the authors of this publication, renders this technology unsustainable as a vaccine technology. Furthermore, the authors appear to be minimizing the correlation between the skewing of T cell clonotypes and the severity of adverse events. It is reasonable to infer that this correlation extends beyond CD4+ T cell-induced immune inflammation (Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers) to encompass immune pathology such as autoimmunity and cancer facilitated by noncytolytic CD8+ T cell effector memory cells.

By presenting these study results as propaganda for next-generation vaccines mRNA vaccines, Tokyo University of Science is conveying a wholly misleading message that can only backfire in terms of enhancing viral immune escape and immune pathology.


[1] RBD: Receptor-binding domain

[2] TCR: T cell receptor
 

jward

passin' thru
Concerned Citizen
@BGatesIsaPyscho

France mRNA ‘Hate Speech’

In France a new law called ‘The Pfizer Amendment’ is seeking to criminalise critics of Pfizer mRNA Technology with up to 1 year in prison or $15,000 fine.

This shows just how much power the Corporation lobbyists & Pharmaceutical Industrial Complex has.

It also suggests that this technology is going sought to be used on a widespread basis in the not too distant future - possibly mandated.

See people ‘dying suddenly’? Do not Criticise, Do Not Pass Go, Go Straight to Jail.
View: https://twitter.com/33_Sigma/status/1767187357470458100?s=20
 

Heliobas Disciple

TB Fanatic
(fair use applies)


On 4-year anniversary of the WHO declaring COVID a pandemic, a look at the virus by the numbers
MARY KEKATOS - ABC News GMA
Mon, March 11, 2024, 6:04 AM EDT

Monday marks the 4-year anniversary of the World Health Organization (WHO) declaring the global COVID-19 outbreak to be a pandemic.

Over that period, millions of Americans have been hospitalized and have died from the virus.

Additionally, a high percentage of adults have developed long COVID while the infections of thousands of children have led to an inflammatory condition.

Here's a look at the COVID-19 pandemic in the U.S. by the numbers:


Covid19BTN_v01_DG_1710167598719_hpEmbed_4x5.jpg



Hospitalizations

As of the week ending March 2, there were 15,141 weekly new hospital admissions for COVID-19. according to data from the Centers for Disease Control and Prevention (CDC).

While this is on par with the number of weekly hospitalizations at the beginning of April 2024, this is much lower than the peak of 150,650 weekly hospitalizations recorded the week of Jan. 22, 2022, during the omicron wave.

Over the course of the pandemic, more than 6 million Americans have been hospitalized, CDC data shows.

The CDC has said fewer people are hospitalized due to the availability of vaccines and boosters as well as the availability of antirural drugs that decrease the risk of severe illness for those at-high risk, including molnupiravir and Paxlovid.

Deaths

Since the pandemic began, more than 1.18 million Americans have died from COVID-19, according to CDC data. The U.S. crossed the 1 million mark on May 12, 2022.

During the week of March 2, there were 576 weekly deaths, which is the lowest number recorded since summer 2023 and several times lower than the peak of 25,974 weekly deaths recorded the week ending Jan. 9, 2021.

Experts have previously said the U.S. is in a much better place than it was at the start of the pandemic but some reasons hundreds of people may be dying every week include not enough people accessing treatments or getting vaccinated as well as waning immunity.

Vaccinations

In early fall, the federal government recommended an updated vaccine that is targeted against variants that are currently circulating, which are related to XBB, an offshoot of the omicron variant.

There are formulations made by Pfizer-BioNTech and Moderna for those aged 6 months and older, and a formulation made by Novavax for those aged 12 and older.

However, as of Friday, just 22.6% of adults aged 18 and older and 13.5% of children under age 18 have received the vaccine, according to CDC data.

This is lower than the nearly half of adults who said they planned to get the vaccine in a poll conducted by the KFF COVID-19 Vaccine Monitor in September.

In some good news, 42.4% of adults aged 65 and older, which is the group at highest risk of severe illness and death, have gotten vaccinated.

MIS-C cases

As of Feb. 26, 9,655 children in the U.S. have developed MIS-C, or multisystem inflammatory syndrome in children, according to CDC data.

MIS-C is an inflammatory condition that is caused by infection with SARS-CoV-2, the virus that causes COVID-19.

It typically occurs between two to six weeks after infection and presents a combination of symptoms, including inflammation of various parts of the body along with gastrointestinal symptoms, rash and fever.

Since the start of the new year, just two cases of MIS-C have been reported, much lower than the peak in winter 2021 when more than 200 cases were being reported every week.

Some children with MIS-C end up hospitalized and, if they are sick enough, can spend time in intensive care units. Additionally, at least 79 children have died of MIS-C so far.

Long COVID

Millions of Americans say they've had long COVID, and many are still battling it, federal data shows.

Long COVID is a condition that occurs when patients still have symptoms at least four weeks after they have cleared the infection. In some cases, symptoms can be experienced for months or years. The WHO first posted a clinical case definition of the condition in October 2021.

According to the most recent federal Household Pulse Survey, between Jan. 9, 2024 and Feb. 5, 2024, 6.8% of U.S. adults currently have long COVID and 17.6% have had long COVID.

Using 2020 U.S. Census Bureau estimates, this means 17.5 million adults currently have long COVID and 45.4 million people have ever had long COVID.
 

Heliobas Disciple

TB Fanatic
Written by the director of the WHO. Posting because it is newsworthy and should be included on this thread.




(fair use applies)


COVID-19 Shows Why the World Needs a Pandemic Agreement
Tedros Adhanom Ghebreyesus

TIME
Mon, March 11, 2024, 1:37 PM EDT

Today marks four years since I said the global outbreak of COVID-19 could be characterized as a pandemic.

My decision to use the “p-word” was not one I took lightly. Pandemic is a powerful word, evoking fear linked to plagues and pandemics throughout history that have claimed millions of lives and caused severe disruption to societies and economies—as COVID-19 did.

Many of WHO’s critics have pointed to my use of “pandemic” on March 11, 2020 as evidence that WHO was “late” in taking the threat of COVID-19 seriously. By that stage, more than 118,000 cases had been reported in 114 countries, and more than 4,000 deaths. The horse had bolted.

However, the far more significant date was January 30, 2020, six weeks earlier, when I declared a public health emergency of international concern (PHEIC)—the highest level of alarm under the International Health Regulations (IHR), an instrument of international law designed to govern the response to global health emergencies. At that time, fewer than 100 cases, and no deaths, had been reported outside China.

A PHEIC has legal and technical meaning; “pandemic” does not—it’s a descriptor, rather than a technical designation.

I declared an end to COVID-19 as a PHEIC on May 5 of last year. Although the crisis has passed, the threat has not. The virus is still circulating, still changing, and still killing.

As countries learn to manage COVID-19 alongside other disease threats, and continue to grapple with the complications of Long COVID, they must also learn the painful lessons of COVID-19, and take corrective action to address deficiencies in the IHR and gaps in global health security that the pandemic exposed.

History teaches us that the next pandemic is not a matter of if, but when. It may be in our lifetime; it may not come for another 100 years or more. But it will come. And as things stand, the world remains unprepared.

That’s not to say nothing has been done. In the past two years, WHO, our Member States, and partners have established several initiatives to detect outbreaks earlier, strengthen sharing of biological samples and sequences, expand regional manufacturing of vaccines and other tools, improve equitable access to medical countermeasures, and strengthen financing of national preparedness and response capacities, especially in lower-income countries.

But there is still one key missing ingredient: an agreed framework between countries on how they will work together to counter the threat of a future pandemic.

The lack of coordination and cooperation between countries was one of the greatest failings of the global response to COVID-19. Countries became competitors, rather than cooperators, especially in seeking access to vaccines.

While the development of multiple safe and effective vaccines in such rapid time was an unprecedented triumph of science, before a single jab reached an arm, high-income countries had used their financial muscle to pre-order most of the world’s supply—often ordering more than they might ever need—leaving lower-income countries behind, waiting for scraps.

Of course, every sovereign government is responsible for protecting its people. But in a pandemic, no country can truly protect itself without working with other countries—especially those with the least financial, technical, or political capital—to ensure they too are protected. A global threat demands a global coordinated response.

Countries have recognized that, which is why they decided to strengthen the IHR and, in December 2021, to develop an international agreement on pandemic preparedness and response—a legally-binding generational pact to work together to keep themselves and each other safe.

They set themselves a deadline of completing the agreement and the IHR amendments in time for adoption at the World Health Assembly in May 2024. That’s now just 10 weeks away.

Countries are making good progress, and have agreed on significant elements of the draft agreement, although there are still some issues which require further negotiation. I remain confident they can and will find common ground.

A more pernicious problem is the avalanche of lies, fake news, and conspiracy theories about the pandemic agreement that are propagating on social and traditional media.

Just as the response to the pandemic itself was hampered by mis- and disinformation, so the agreement’s negotiators are operating amid a frenzy of falsehoods: That the agreement is a power grab by WHO; that it will give WHO power to impose lockdowns or vaccine mandates on countries; or that it’s an attack on freedom.

These claims are completely false. WHO does not have, and has never had, the power to impose anything on anyone. We don’t want that power, and we’re not trying to get it.

The agreement is being written by countries, for countries, and will be implemented in countries in accordance with their own national laws. No country will be signing away its sovereignty to WHO. Why would it?

Legally-binding international agreements are not new. They are a tool that countries have used often since the end of the Second World War to meet common threats with a common response: the Geneva Conventions; the UN Charter; the Nuclear Non-Proliferation Treaty; the Paris Agreement; the WHO Framework Convention on Tobacco Control; and the WHO Constitution, to name a few.

All are binding agreements in international law, and none give UN staff, including me, power to dictate to sovereign states.

In his classic novel La Peste, Albert Camus wrote, “There have been as many plagues as wars in history, yet always plagues and wars take people equally by surprise.”

As the generation that lived through the COVID-19 crisis, we have a collective responsibility to protect future generations from the suffering we endured.

Because pathogens have no regard for the lines humans draw on maps, nor for the color of our politics, the size of our economies, or the strength of our militaries.

For everything that makes us different, we are one humanity, the same species, sharing the same DNA and the same planet.

We have no future but a common future.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Covid lowered life expectancy by 1.6 years worldwide: study
Daniel Lawler - AFP
Mon, March 11, 2024, 8:06 PM EDT

Covid-19 caused the average life expectancy of people worldwide to fall by 1.6 years during the first two years of the pandemic, a more dramatic decline than previously thought, a major study said Tuesday.

This marked a sharp reversal during a decades-long rise in global life expectancy, according to hundreds of researchers sifting through data for the US-based Institute for Health Metrics and Evaluation (IHME).

"For adults worldwide, the Covid-19 pandemic has had a more profound impact than any event seen in half a century, including conflicts and natural disasters," said Austin Schumacher, an IHME researcher and lead author of the study published in The Lancet journal.

During 2020-2021, life expectancy declined in 84 percent of the 204 countries and territories analysed, "demonstrating the devastating potential impacts" of new viruses, he said in a statement.

The rate of death for people over 15 rose by 22 percent for men and 17 percent for women during this time, the researchers estimated.

Mexico City, Peru and Bolivia were some of the places were life expectancy fell the most.

But there was some good news in the updated estimates of the IHME's landmark Global Burden of Disease study.

Half a million fewer children under the age of five died in 2021 compared to 2019, continuing a long-term decline in child mortality.

IHME researcher Hmwe Hmwe Kyu hailed this "incredible progress," saying the world should now focus on "the next pandemic and addressing the vast disparities in health across countries".

And despite the setback during the pandemic, people still live far longer than they used to.

Between 1950 and 2021, the average life expectancy at birth has risen by 23 years, from 49 to 72, the researchers said.

- 16 million Covid-linked deaths -

Covid was responsible for 15.9 million excess deaths during 2020-2021, either directly from the virus or indirectly due to pandemic-related disruptions, the researchers estimated.

That is a million more excess deaths than previously estimated by the World Health Organization.

Excess deaths are calculated by comparing the total number of deaths with how many would have been expected if there had not been a pandemic.

Barbados, New Zealand and Antigua and Barbuda were among the countries with the lowest rate of excess deaths during the pandemic, partly reflecting how isolated islands were often spared the full brunt of Covid.

The study also showed how the populations of many ageing, well-off countries have started to decrease, while numbers continue to grow in less wealthy countries.

This dynamic "will bring about unprecedented social, economic, and political challenges, such as labour shortages in areas where younger populations are shrinking and resource scarcity in places where population size continues to expand rapidly," Schumacher warned.

"Nations around the world will need to cooperate on voluntary emigration," he added.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


COVID Vaccine Gene Could Integrate Into Human Cancer Cells: Researcher
What Mr. McKernan and his team have found contradicts the latest arguments from fact-checkers.

By Marina Zhang
3/11/2024

Following his discovery of DNA contamination in COVID-19 mRNA vaccines, genomic researcher Kevin McKernan has recently found that the DNA in these vaccines can potentially integrate into human DNA.

The COVID-19 vaccine spike sequence was detected in two types of chromosomes in cancer cell lines following exposure to the COVID mRNA vaccine. Mr. McKernan’s findings, which he presents on his Substack blog, haven’t been peer-reviewed.

These are expected to be “rare events,” but they can happen, Mr. McKernan told The Epoch Times.


DNA Integration

Since the introduction of the COVID-19 mRNA vaccines, some members of the public have been concerned that the vaccines may modify the human gene by combining their sequences with the human genome.

“Fact-checkers” refuted this, stating that mRNA cannot be changed into DNA. Yet Mr. McKernan’s earlier work shows that DNA in the vaccine vials may be capable of changing human DNA.

Biologist and obstetrics-gynecology professor Ulrike Kämmerer at the University Hospital of Würzburg conducted earlier stages of this research.

Exposing breast and ovarian human cancer cells to Pfizer and Moderna mRNA vaccines, Ms. Kämmerer found that around half of the cells expressed the COVID-19 spike protein on their cellular surface, indicating they had absorbed the vaccines.

Mr. McKernan then performed gene sequencing and found that these cells, as well as their descendant cells, contained vaccine DNA.

After this, he tested to see if any vaccine DNA combined with the cancer cell DNA, a process known as DNA integration. Integration is more of a concern in healthy cells than cancer cells since it disrupts cells’ genetic stability and integrity, increasing cancer risk.

However, because cancer cells already have unstable DNA, the effects of DNA integration are less clear.

Currently, in biomedical research, most experiments are carried out in cancer cell lines as they are easier to obtain, experiment on, and maintain in the laboratory.

Mr. McKernan detected vaccine DNA sequences on two chromosomes in the cancer cell lines: chromosome 9 and chromosome 12. The sequencing machine detected both instances of integration twice. It is important to get two readings of the DNA integration to ensure the integration is not a result of misreading or random error, he added.

“The integration of ‘vaccine’ genetic information into the genome of cells was not such a surprise for me—more the confirmation of what we had to expect, unfortunately,” Ms. Kämmerer told The Epoch Times.

Mr. McKernan said it is unsurprising that integration was only detected on two chromosomes with two readings of each integration. This is because integration is rare, and the genes must be sequenced many times to get more sensitive results.

The current findings are still preliminary, Mr. McKernan said. More tests are also needed to determine whether DNA integration could be passed on to descendant cancer cells and whether this may affect cancer patients.

Also, since the test was conducted in cancer cells and not in healthy human cells, it does not suggest the same integration would occur in healthy human cells.

However, Hiroshi Arakawa, a researcher at the Institute of Molecular Oncology with a doctorate in molecular biology and immunology, wrote in his blog that “what happens in cultured cells can also occur in normal cells” after examining Mr. McKernan’s data.

His review of Mr. McKernan’s data also found signs of DNA integration at chromosomes 9 and 12.
“A wide variety of abnormalities can occur [in normal cells] depending on the site of genome integration,” Mr. Arakawa added.


Not Random Events


The two integration events into chromosome 9 occurred at the same place, as did the integration events into chromosome 12.

Mr. McKernan said that the odds of this occurring is one in 3 billion, highlighting that where the DNA integrates may not be random.

“There’s likely hotspots for this,” he told The Epoch Times, highlighting that in the human genome, jumping genes—short segments of DNA sequences—tend to “jump” into highly activated areas of DNA.

Highly activated DNA tends to play important roles in the human body.

The DNA integration into chromosome 12 occurred within the FAIM2 gene. Once activated, this gene creates a protein involved in programmed cell death. Since cancer cells evade cell death, the integration at chromosome 12 may be a survival-driven change.


Vaccine DNA Is Active in the Cells

Mr. McKernan believes vaccine DNA is highly active in cancer cells. His sequencing machine detected the DNA of cancer cells 30 times but detected spike DNA 3,000 times.

Not only did he detect much higher levels of vaccine DNA, but he also detected new variants in certain segments of the vaccine DNA.

These new DNA variations were not observed in unvaccinated cancer cells nor in the vaccine not exposed to the cancer cells.

Mr. McKernan believes that these new gene variants likely occurred because the cancer cell made copies of the vaccine DNA and created small errors.

What he and his team have found contradicts the latest arguments from fact-checkers claiming that the DNA from the mRNA vaccines cannot get into the cell, nor can it be active, he said.


DNA Contamination From mRNA Vaccine Manufacturing

DNA is present in the COVID-19 mRNA vaccines due to the manufacturing process.

This has been verified by the U.S. Food and Drug Administration (FDA), Health Canada, and the European Medicines Agency.

The mRNA vaccines are made from DNA; some of this DNA persists in the final product due to insufficient clearance.

Initially, Pfizer reported that it would use a PCR machine to produce the DNA for its mRNA vaccine. The PCR machine first makes many copies of DNA, which is then sequenced into RNA.

However, because this process wouldn’t be fast enough to meet demands, the vaccine manufacturers switched to using bacteria to mass-produce DNA as the template for the mRNA vaccine.

In this process, vaccine manufacturers introduce bacterial DNA containing the vaccine spike sequences.
The bacteria make many copies of this spike DNA as they divide. This spike DNA is then harvested and transcribed into mRNA in a machine. The mRNA is then packaged into lipid nanoparticles for use in vaccination.

However, some bacterial DNA containing spike protein and other sequences could be packaged into lipid nanoparticles during the process, which would then be transported into cells during vaccination. Mr. McKernan’s earlier works have demonstrated this.

Works by molecular virologist David Speicher have shown that the amount of DNA in the mRNA vaccine vials is higher than the FDA’s allowable threshold of 10 nanograms per vaccine dose.

Mr. McKernan highlighted that compared to previous vaccines, mainly composed of naked DNA that had difficulty entering the cells, the DNA carried in the mRNA vaccines presents greater health risks, as it is packed into lipid nanoparticles and delivered straight into the cells.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Vaccine monitoring is crucial as SARS-CoV-2 variants continue to evolve, says study
by The Francis Crick Institute
March 11, 2024

Researchers at the Francis Crick Institute and the National Institute for Health and Care Research Biomedical Research Centre at UCLH have highlighted the importance of continued surveillance of emerging SARS-CoV-2 variants and vaccine performance as the virus continues to evolve.

Published today as a research letter in The Lancet, their study compared the newer monovalent COVID vaccine, which specifically targets the XBB variant of omicron (as recommended by the World Health Organization), with older bivalent vaccines containing a mix of an omicron variant and the original strain of COVID-19, which the UK deployed in autumn 2023 before turning to monovalent vaccines.

The researchers found that both vaccines generated neutralizing antibodies against the most recent strain of omicron, BA.2.86. However, the new monovalent vaccine generated higher levels of antibodies against a range of other omicron variants.

The team collected blood and nasal mucosal samples both before and after a fifth dose vaccination from 71 participants of the Legacy study, a research collaboration between the Crick and the NIHR University College London Hospitals Biomedical Research Centre. They compared the antibody levels before and after vaccination.

All 36 participants who received the bivalent vaccine and 17 who received the monovalent vaccine had boosted levels of antibodies against all variants tested, including the newest strain BA.2.86, which caused a wave of infection this winter. But those with the newer monovalent vaccine had 3.5x higher levels of antibodies against the XBB and BQ.1.1 strains after their booster vaccination.

Since the omicron virus is highly transmissible and the virus replicates in the nose and throat, the researchers tested the levels of antibodies in the participants' nasal cavity.

They found that the monovalent vaccine increased their ability to produce mucosal antibodies against most of the tested variants, whereas the bivalent vaccine didn't provide a significant boost.

Neither vaccine increased neutralizing antibody levels in the nasal cavity against the newest variant, BA.2.86, suggesting that current vaccines may be less likely to stop transmission or prevent asymptomatic or mild illness, while still protecting against severe disease.

This highlights the importance of careful vaccine updates and continuing to complement a vaccination program with the development of antibody drugs that work against all variants, as some more vulnerable people don't respond well to vaccines.

Emma Wall, Senior Clinical Research Fellow at the Crick and Consultant in Infectious Diseases at UCLH, said, "The UK's strategy to deploy stocks of older vaccines paid off last year, as both vaccines provided equal protection against the newest strain. However, ongoing monitoring is needed, as the virus is continuing to evolve, so vaccine-induced antibodies might not work so well in the future. In the long run, vaccines that are effective against all new variants and can block COVID-19 being transmitted from person to person are needed."

David LV Bauer, Group Leader of the RNA Virus Replication Laboratory at the Crick, said, "The situation this winter could have been different if the newly emerged BA.2.86 and JN.1 variants were substantially distinct from older omicron variants, but fortunately this wasn't the case.

"Most new variants arise quicker than most clinical trials can produce data. But laboratory analysis can provide a detailed picture very quickly. Continued surveillance will help us stay on top of viral evolution."

More information: Shawe-Taylor, M and Greenwood, D. et al, Divergent performance of vaccines in the UK autumn 2023 COVID booster campaign, The Lancet (2024). DOI: 10.1016/S0140-6736(24)00316-7. www.thelancet.com/journals/lan … (24)00316-7/fulltext
Journal information: The Lancet
Provided by The Francis Crick Institute
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Call for collaboration on in vivo NK cell-based immune interventions
By Geert Vanden Bossche
March 11, 2024

N(atural)K(iller) cell-based immune interventions are causing a great deal of excitement and have strengthened the belief that NK cells can effectively contribute to fighting infectious diseases or controlling cancer. Several studies provide compelling evidence of antigen-specific recall responses of memory NK cells but the molecular interactions between NK cell receptors and cognate pathogen-associated motifs, or patterns thereof, remain largely unknown.

Scientists increasingly acknowledge that an improved understanding of the mechanisms that enable prolonged immune recognition of pathogen-associated motifs by a diversified spectrum of memory NK cells may enhance the efficacy of NK cell-based immunotherapies and even pave the way to NK cell vaccines against infectious, immune-mediated or tumor diseases. The notion that NK cells could possess an alternative ligand-sensing system is particularly intriguing and may require the scientific and medical community to re-think approaches to investigating NK cell-based immune responses and triggering NK cells to recognize and target infected or otherwise pathologically altered cells. Hence, the time has come for vaccinologists to learn from immunologists to further explore and exploit immunization strategies that harness NK cells to acquire adaptive immune features and eliminate such infected, transformed or otherwise pathologically altered host target cells.

Over the past decade, my focus has been on exploring how NK cell immunology could be harnessed to address a major medical need and significant gap in current vaccinology: equipping our natural and innate first line of immune defense with adaptive immune features. Based on promising proof-of-concept data, I am confident that simple, safe, and highly cost-effective constructs can be developed to educate NK cells in vivo, enabling them to acquire pathogen-specific cytolytic activity and adaptive memory. Guided by immunological principles, I view this novel approach as a more rational and natural path to immunization, laying the groundwork for the next generation of in vivo prophylactic and therapeutic immune interventions.

I tend to believe that the interaction of this novel type of immunocompetent constructs with host cells generates molecular patterns capable of clustering natural cytotoxicity receptors (NCRs) in ways that trigger NK cells to target a multitude of conserved, pathogen-associated motifs through their epigenetic reprogramming (‘training’). I cautiously believe that this mechanism could even harness the host’s innate immune system to protect against all SARS-CoV-2 variants, regardless of previous vaccination.

I am reaching out to scientists - for logistical reasons, preferably in Europe - who are interested in collaborating on this groundbreaking concept and help me determine the immunological potential of these new constructs. Specifically, I am seeking research groups with extensive experience in the functional and phenotypic characterization of NCRs on NK cells, including the versatile expression of NCRs and the impact thereof on NK cell-mediated cytotoxicity and IFN-? secretion.

The objective of this collaboration is to share critical knowledge, experience and insights on mechanisms enabling in vivo education of NK cell-mediated immune recognition of pathogenic agents. I am currently in the process of applying for philanthropic funding with the goal of providing global access if the results from previous in vitro experiments and in vivo challenge experiments in animals can be corroborated.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


How SARS2 vaccination fueled the global Dengue epidemic
Radagast
March 11, 2024

Bangladesh: Nearly 1,000 people die of dengue in severe outbreak

Floods and Heat Cause Peru’s Worst-Ever Dengue Outbreak

Dengue Cases Approach Historic Highs Worldwide; Local Transmission Seen In Europe

Brazil’s staggering dengue fever crisis is a warning to the world

You can read these articles for yourself, if you want to.

But personally, I’m more interested in explaining one thing. There are a number of differences between the SARS-COV-2 vaccines and almost every other vaccine human beings receive. When you receive a measles or polio vaccine, these vaccines are supposed to protect you from ever catching these viruses. In fact, when things go as planned, you’re not even supposed to encounter those viruses anymore.

1hybridimmunity-1.jpeg


That’s not the case with the SARS-COV-2 vaccines. These vaccines are sold to the public, with the promise of reducing the severity of a virus that will infect them twice a year or more, by maintaining chronically elevated levels of antibodies, as illustrated in the above image I borrowed from a Nature publication.

The idea here, the unspoken implicit assumption, seems to be that antibodies are like money in your bank account: You can’t have enough of them. But that’s just not how this works in nature. Once you move from petri dishes, lab rats and a couple hundred volunteers, to the real world, it becomes important to know how these changes interact with the world around us, which is full of numerous pathogens.

Because have a look at what we see when you look at what these antibodies do against Dengue:
Dengue disease is highly prevalent in tropical and subtropical regions worldwide. However, its pathogenesis is still incompletely understood, particularly in comparison to other endemic viruses. Antibody-dependent enhancement (ADE) is a well-known phenomenon for dengue viruses. Given the recent surge in dengue cases and potential cross-reactivity with SARS-CoV30 2 antibodies, this study explores the impact of anti-SARS-CoV-2 antibodies on DENV-2 infection. The study assessed the cross-reactivity of SARS-CoV-2 antibodies with the DENV-2 Virus.
Human convalescent plasma samples collected during different waves of COVID-19 and monoclonal and polyclonal antibodies raised against SARS-CoV-2 were examined for their potential to cause ADE of DENV-2 infection using cell-based assays. The study found that anti SARS-CoV-2 antibodies acquired from natural infection in humans or through experimental immunization in animals were cross-reactive with DENV-2 and had the potential to enhance DENV-2 infection in K562 and U937 cells. In-silico and in-vitro studies indicated a strong interaction between SARS-CoV-2 antibodies and DENV-2 E-protein, providing a molecular basis for these findings. This study is the first to demonstrate that anti-SARS-CoV-2 antibodies can cross-react with DENV-2 and can enhance its infection through ADE. These findings have implications for SARS-CoV-2 vaccine development and deployment strategies in regions where dengue is endemic

I’ve told you before, I look at this experiment like a student of nature would. Most people are asking themselves whether they’re going to get myocarditis or some other adverse effect. But I’ve said before, that the biggest problems take a few years to reveal themselves. This study was only published a few months ago. Until that time we just had speculation, like when I asked out loud what this abnormal IgG4 response is going to do to all the other pathogens circulating out there.

This problem is not something I invented myself after a high dose of Amnesia Haze, it’s just a basic principle of nature. It has been known for a long time: Live vaccines tend to provide protection against unrelated pathogens, by stimulating innate immunity. Inactivated vaccines on the other hand have the opposite effect, they reduce protection against unrelated pathogens, by interfering in the innate immune response. This is especially true, if they induce an IgG4 antibody response. I quote:
High IgG4 antibody levels generated in response to repeated inoculation with mRNA COVID-19 vaccines could be associated with a higher mortality rate from unrelated diseases and infections by suppressing the immune system.

There are a lot of things vaccine manufacturers and public health agencies asked themselves in 2021. I can guarantee you there is one question that did not enter these people’s minds: “What will this do to the global Dengue epidemic?”
They could have just done nothing. Some people would catch the first few variants, then eventually Omicron would come along and infect the rest. Most young people would never even have developed a detectable antibody response to the Omicron variants. Then eventually, the SARS2 viruses would have struggled to compete against the cocktail of other viruses that regularly spread themselves through our species.

Over time the intrinsic fitness of the virus would have declined, transmission would have been low enough to prevent recombinants from emerging that inherit the best of both worlds. In addition, people’s antibody response would have discriminated against virulent variants of the virus. But vaccinate everyone and there can be no discrimination against virulence. In the absence of active discrimination against virulence, virulence has a fitness advantage.

That’s the main thing that sets SARS2 apart, from the many other corona viruses that jumped into our species. For all the other viruses, people will develop a small number of high affinity IgG antibodies against specific regions of the receptor binding domain. Concentrations of those antibodies will depend on how severe their infection was. This means versions that cause severe infections bump into their own antibodies upon reinfection, whereas milder versions of the virus don’t. After vaccination the population has high concentrations of antibodies that are variant independent against conserved epitopes, so you don’t get this benefit of discrimination against virulence.

Unfortunately, this is the hardest thing for human beings to do: Nothing. And now the result may very well be, that you successfully introduced a new virus into Europe:
Cases of locally transmitted dengue on the European mainland were rare, as statistics collected between 2015 and 2019 show: European countries where the mosquito that spreads dengue is established, saw about 3,000 cases of travel-related dengue, but only 9 cases of local transmitted dengue.
But in 2022, cases rose higher than in the past seven decades on the European mainland combined — with 65 cases in France alone.
In 2023, the number of cases rose even higher — more than 110 cases, largely in France and Italy, and a handful in Spain.
I’ve said it before and I’ll say it again: The vaccines turned SARS-COV-2 effectively into a guest of honor in the human body. The body now rolls out the red carpet for it. This happened because the virus maintained those regions where infection enhancing antibodies bind, while changing the regions where neutralizing antibodies bind:
We analyzed … 16 anti-NTD neutralizing antibodies, and found that none of the anti-NTD neutralizing antibodies could recognize Delta spike … In contrast, when we analyzed the binding of the anti-NTD infectivity-enhancing antibodies … eight out of ten anti-NTD enhancing antibodies bound to Delta spike at levels comparable with wild-type spike …
I’ve seen many people on the Internet argue that “antibody dependent enhancement didn’t happen”. It did happen, it just didn’t look like what you thought it would. It led to constant waves of reinfections, you artificially turned SARS-COV-2 into one of the fittest viruses infecting our species. Those constant waves of reinfections damaged people’s immune systems.

But other pathogens may need some time, to optimally make use of the brave new world in which the whole immunological landscape is reoriented towards SARS-COV-2. You’ll encounter this problem for other viruses besides Dengue, if people bother to study it. The best candidate to study may be RSV.
 

Zoner

Veteran Member

Heliobas Disciple

TB Fanatic
(fair use applies)


Take caution resuming your fitness routine after Covid, RSV or influenza, experts say

Melanie Radzicki McManus, CNN
Tue, March 12, 2024, 7:52 AM EDT

You’re finally sticking to your New Year’s resolution to exercise regularly when you become sidelined by Covid-19. Or maybe you’re a seasoned fitness buff training for a marathon, then have to hit pause due to a nasty bout with respiratory syncytial virus or influenza.

No matter the scenario, the big question is how to safely reboot your fitness regimen once you have recovered.

If you had a simple head cold or 24-hour stomach flu bug, there is not too much to be concerned about. But Covid, RSV and influenza are more serious maladies that require a thoughtful approach to resuming exercise. That’s because the three are viral infections, which tend to cause whole-body inflammation, said Dr. R.J. Turner, a primary care and sports medicine physician with UTHealth Houston.

“What that inflammation can do is irritate your heart and lungs, which ultimately can affect your breathing and the way your heart beats,” Turner said. “It takes time for your body to completely recover from a viral infection.”

It can take even longer than average to be ready to hit the gym if you’re an older adult or have underlying health concerns, such as diabetes or high blood pressure. And if you already had heart or lung issues, that requires even more caution.

Another factor to consider is how long you’ve been ill and inactive. “You start to lose strength in your muscles after five to seven days of inactivity,” said Marisella Villano, a certified personal trainer and owner of Marvil Fit in Hampton Bays, New York.

Indeed, your muscles can begin to atrophy within eight hours of surgery. And being bedridden for less than two weeks can result in a 5% to 10% reduction in muscle mass in your quadriceps, according to a 2013 study published in The International Journal of Biochemistry & Cell Biology.
Planning your return

No matter which virus you had, wait at least five to seven days after recovering before packing your gym bag. You also should be able to do all of your daily activities without excessive fatigue.

“Your body, heart and lungs need to recover,” Turner said. “You don’t want to push it too early and then have complications.”

If you had Covid accompanied by heart- or lung-related symptoms such as chest pain or difficulty breathing, the American College of Cardiology recommends seeing your physician before resuming exercise. And if Covid caused you to develop myocarditis, an inflammation of the heart, the ACC guidelines say to abstain from exercising for three to six months.

Once you’re cleared to resume your workouts, take it slow and easy. Turner recommended calculating your maximum heart rate and keeping it below 70% to start, which is considered light exercise. To determine your maximum heart rate, first subtract your age from 220, then calculate 70% of that. For example, a 40-year-old would have a maximum heart rate of 180 beats per minute (220 minus 40). Since 70% of 180 is 126, a 40-year-old’s heart rate should initially stay below 126 beats per minute. You can use a heart-rate monitor or fitness watch to track your heart rate.

Villano recommended walking at an easy pace for the first 10 days post-recovery before progressing to more moderate exercise. “But don’t go back to 100% of what you were doing before you became ill,” she said. “Decrease your loads by at least 10% or 15%.”

At her fitness studio, some of Villano’s clients tried to jump right back into their workouts after a bout with Covid, despite her warning against it. The result was always the same: The overly eager go-getters fatigued earlier than previously, as their heart rates accelerated at lower workloads than before their illness. Some got lightheaded.

“I have to talk them off the ledge and tell them their gains are cumulative,” she said. “Decreasing your workload doesn’t mean you will lose all of your gains.”
Monitor how you’re feeling

As you’re slowly working back to your normal fitness routine, pay attention to how you’re feeling. Yes, you’ll likely feel some fatigue as you get back into shape. But if you feel like your heart is racing or beating irregularly, or if you have any chest pain, stop immediately and see your physician.

“The biggest thing to be concerned about are heart attacks and developing heart arrhythmias,” Turner said.

Being well-hydrated and consuming nutritious foods are also crucial, Turner said, both while you’re ill and when you’re returning to activity. That’s because your body needs energy to fight off the infection while you’re sick and later to fuel your workouts.

Should you become frustrated or down about how long it’s taking to get back in shape, remember this: Those who are physically active are less likely to become ill, and if they do catch an infection, it’s typically less severe than for someone who is a couch potato.

“At the end of the day, the healthier we are, the better outcomes we have if we do get sick,” Turner said.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


U.S. airport nasal swabbing expanding to Chicago and Miami
By MIKE STOBBE
March 12, 2024

NEW YORK (AP) — The nation’s top public health agency is expanding a program that tests international travelers for COVID-19 and other infectious diseases.

The Centers for Disease Control and Prevention program asks arriving international passengers to volunteer to have their noses swabbed and answer questions about their travel. The program operates at six airports and on Tuesday, the CDC said it was adding two more — Chicago’s O’Hare and Miami.

Those locations should provide more information about respiratory infections coming out of South America, Africa and Asia, particularly, CDC officials said.

“Miami and Chicago enable us to collect samples coming from areas of the world where global surveillance is not as strong as it used to be,” said the CDC’s Allison Taylor Walker. “What we really need is a good view of what’s happening in the world so we’re prepared for the next thing.”

The program began in 2021, and has been credited with detecting coronavirus variants faster than other systems. The genomic testing of traveler’s nasal swabs has mainly been focused on COVID-19, but testing also is being done for two other respiratory viruses — flu and RSV.

Participants are not notified of their results. But they are given a COVID-19 home test kit to take with them, CDC officials say.

Samples have come from more than 475,000 air travelers coming off flights from more than 135 countries, officials said.

Health officials also have been sampling wastewater that comes off international flights at a few airports. That testing is for COVID-19, but CDC officials are evaluating the possibility of monitoring wastewater for other things, Walker said.

The CDC program has a current budget of about $37 million. The agency pays two companies, Ginkgo Bioworks and XWell, to do sample collection and testing. The companies are working with CDC to grow
the program to check for more than 30 different disease-causing germs.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


President Biden Signs Bill Package With Ban on Mask Mandates Tucked Inside
The legislation was inside the $460 billion spending package that the president signed to avoid a partial government shutdown.

By Jana J. Pruet
3/12/2024

President Joe Biden signed a $460 billion package of spending bills over the weekend to avoid a partial government shutdown, which included Sen. J.D. Vance’s (R-Ohio) legislation banning federal mask mandates from the Department of Transportation.

The law, known as the “Freedom to Breathe Act,” prohibits the Transportation Department from using federal monies to enforce mask mandates on passenger airlines, busses, rail, and any other transportation program funded through fiscal year 2024.

“The era of public health panic is over,” Mr. Vance said in a statement following the bill’s passage. “Tonight, my amendment to prohibit COVID-19 mask mandates by the Department of Transportation—including the FAA—passed the Senate. This is a massive victory for common sense. Mask mandates were an outrageous overstep by the public health establishment. We cannot allow this mistake to be repeated.”

The Ohio Republican’s legislation was introduced in September 2023 after some public health officials began calling for mask mandates following a surge in COVID-19 cases. Some businesses, hospitals, and universities, including Morris Brown College in Atlanta, Georgia, imposed mask mandates after the uptick in cases.

Republican Sens. John Thune of South Dakota, John Barrasso of Wyoming, Cynthia Lummis of Wyoming, Ted Budd of North Carolina, and Eric Schmitt of Missouri co-sponsored the legislation.

In September, Mr. Vance asked the Senate for unanimous approval in an attempt to force the bill’s passage, but Sen. Ed Markey (D-Mass.) objected, citing the bill was misleading. He argued that officials at the local level should have every healthcare option available to them.


Support From Air Marshal Association

“We tried mask mandates once in this country,” Mr. Vance said in a statement last year. “They failed to control the spread of respiratory viruses, violated basic bodily freedom, and set our fellow citizens against one another. This legislation will ensure that no federal bureaucracy, no commercial airline, and no public school can impose the misguided policies of the past. Democrats say they’re not going to bring back mask mandates—we’re going to hold them to their word.”

The Air Marshal Association also backed Mr. Vance’s bill, which it described as “common-sense legislation.”
“We support a permanent ban on masking requirements in public transportation, but believe that prohibiting masking requirements through December 31, 2024, will send a clear message,” wrote John Cassaretti, president of the Air Marshal Association, in a letter to Mr. Vance.

“Federal air marshals were routinely diverted from their national security mission to monitor and respond to masking related incidents, or were asked by air crews to intervene with non-compliant passengers,” the letter continued.

Mr. Cassaretti also noted that he had testified during an open Congressional hearing about the “sharp increase in violence on aircraft,” adding that “air crews and aviation workers had suffered direct physical attacks because they were tasked with enforcing arbitrary masking requirements.”

The following month, Mr. Vance filed the legislation as an amendment to an appropriations bill which passed the Senate.

“This is a massive victory for personal freedom in this country,” Mr. Vance said. “We saw countless abuses of authority throughout the COVID pandemic, and the American people were justifiably enraged by unscientific mask mandates. Today, the United States Senate took an emphatic step toward common sense and individual liberty. I’m proud of what we’ve accomplished here and look forward to continuing the fight.”


Local Mask Mandates

In January, officials in Monmouth County, New Jersey, reimposed an indoor mask mandate at the Sandy Hook unit of the Gateway National Recreation Area amid an increase in COVID-19 hospitalizations.

“Masks are currently required in all federal buildings in Sandy Hook,” according to a statement on the park’s website. “Monmouth County is at HIGH Covid-19 community level, as identified by the CDC.

The Centers for Disease Control and Prevention (CDC) consider readings above 20 per 100,000 as high. The number of COVID-19 hospitalizations in Monmouth County was 20.4 per 100,000, according to CDC data on Jan. 12.

California, New York, and Illinois were among a handful of states that also implemented mask mandates earlier this year.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Clinic That Vaccinated 14-Year-Old Without Parental Consent Shielded by Federal Law: Court
The law protects the clinic and local officials, the ruling states.

By Zachary Stieber
3/12/2024

A broad federal law imposed under President George W. Bush shields a clinic that gave a child a COVID-19 vaccine without parental consent, according to a recent ruling.

The Old North State Medical Society, whose workers injected the boy, is covered by the Public Readiness and Emergency Preparedness Act, the North Carolina Court of Appeals said on March 5.

The Guilford County Board of Education, which was also sued by the boy and his mother, is also shielded by the law, known as the PREP Act, the court found.

“We are of course very disappointed in the ruling, and we are currently weighing all of our options going forward,” Steven Walker, an attorney representing the appellants, told The Epoch Times in an email.

The appellants could ask the North Carolina Supreme Court to review the case.

The medical society and the board of education did not respond to requests for comment.


Injected Without Permission

Tanner Smith was 14 years old in August 2021. He was attending Western Guilford High School, which is part of Guilford County Schools, and playing football there.

The district informed Tanner’s mother, Emily Happel, and stepfather on Aug. 19, 2021, that Tanner may have been exposed to a cluster of COVID-19 cases. The district conveyed that local health officials were recommending students get tested, regardless of vaccination status. Players who declined testing would not be able to return to practice until they were cleared by a doctor.

In the letter, the district noted there would be testing provided for free at one of the district’s schools the following day. A free vaccination clinic was taking place at the same location, although that was not noted in the letter.

Tanner’s stepfather took him to the clinic, but stayed in the car as the boy went inside. According to plaintiffs, Tanner filled out a form he thought was for a test. An Old North State Medical Society worker tried calling Ms. Happel to get permission to vaccinate Tanner, but she did not answer. Workers did not try contacting Tanner’s stepfather.

One worker told another worker to “give it to him anyway,” according to court filings. Tanner said he did not want a vaccine and had come for a test, but one of the workers injected him with the Pfizer-BioNTech COVID-19 vaccine. The shot was available to 14-year-olds under emergency use authorization at the time.

Ms. Happel and Tanner sued in 2022, alleging battery and violations of their constitutional rights on the state and federal levels.

“No matter what your position is on vaccines, we should all be able to agree that children should not be subjected to medical procedures without their parents’ knowledge and consent,” Mr. Walker said at the time.

North Carolina Superior Court Judge Judge Lora Cubbage dismissed the case, finding the clinic and the district were protected by the PREP Act, even though flyers for the vaccination clinic stated that students must receive parental consent to receive a vaccine.

The PREP Act covers COVID-19 vaccinators and others after, during President Donald Trump’s administration, the health secretary issued a PREP Act declaration. That declaration has since been extended multiple times.


Appeal Lodged, Rejected

In the appeal, lawyers for Ms. Happel and Tanner argued the PREP Act does not apply because their claims “are not because this relates to COVID-19, but they happen to relate to COVID-19.”

The claims “are not dependent on COVID-19 and the COVID-19 vaccine and its administration,” they said. “Those claims would result regardless of what substance had been administered to Tanner. It matters not whether it was a COVID-19 vaccine, a chickenpox vaccine, an Aspirin, or open-heart surgery.”

“Taking the trial court’s interpretation of the PREP Act to its logical conclusion, had defendants injected Tanner with saline, they would have been liable, but since they injected him with a vaccine they are not liable. Should a covered person have a slip-of-the-hand and inject saline into a person’s heart there would be no immunity, but if the substance was a COVID-19 vaccine, there would be immunity,” they added. “This certainly could not be the intent of Congress. The intent of Congress, when reading the Act as a whole, was to limit the liability for adverse effects and promote the quick development and deployment of the countermeasure, not to give carte blanche to medical providers to perform medical procedures without consent.

The appeals court, though, said the argument was not correct.

“We would be inclined to agree if the PREP Act did not define the scope of immunity so broadly,” Judge April Wood wrote in the unanimous ruling.

She pointed to three previous rulings, including a lawsuit brought after a woman went to a Walgreens for an influenza vaccine but was given a COVID-19 vaccine without her knowledge.

The U.S. District Court for the District of North Dakota said in response that in the PREP Act, “Congress plainly provided immunity under both federal and state law with respect ‘to all claims for loss caused by, arising out of, relating to, or resulting from the administration to or the use by an individual of a covered countermeasure.'”

“We conclude that these cases are instructive persuasive authorities supporting our holding that the broad scope of immunity provided by the PREP Act applies to both Defendants in this case. Although Plaintiffs’ claims could arise no matter what type of vaccine Tanner was given without parental consent, the PREP Act provides immunity to Defendants because it shields them from ‘any claim for loss that has a causal relationship with the administration” of the COVID-19 vaccine,’” Judge Wood wrote.

The only exception in the PREP Act is in cases of willful misconduct and Ms. Happel and Tanner did not provide any arguments of such misconduct, the appeals court said. The law defines such misconduct as actions taken “intentionally to achieve a wrongful purpose,” without legal or factual justification, and “in disregard of a known or obvious risk that is so great as to make it highly probable that the harm will outweigh the benefit.”

James Lawrence, former deputy general counsel at the U.S. Department of Health and Human Services, said on X that the case “illustrates risk allocation issues related to COVID-19 vaccine mandates” and shows why state-level efforts are important, because “they block mandates, giving students, workers, and parents the right to chart their own course on the shot.”

The ruling came on the same day Rep. Chip Roy (R-Texas) introduced a bill that would strip COVID-19 vaccine manufacturers of the protection they enjoy from the PREP Act.

Mr. Roy said the bill was being introduced “to empower Americans to remove crony federal liability protections for COVID-19 vaccine manufacturers and empower injured Americans.”
 

Heliobas Disciple

TB Fanatic
As a non-member of X (twitter), I can't search it or find links, I can only follow them to that specific tweet.

I saw this image and am bringing it over but if someone who is a member can find the link and post it that would be appreciated.

RFK Jr. posted this tweet about Trump and covid. Apparently, IMHO, he is not a serious candidate (see this thread posted today POL - RFK Jr Considering Aaron Rodgers, Jesse Ventura As Potential Running Mates ) but still interesting that he's willing to debate the vaccine with both candidates.

RFK Jr.JPG
 

Zoner

Veteran Member
As a non-member of X (twitter), I can't search it or find links, I can only follow them to that specific tweet.

I saw this image and am bringing it over but if someone who is a member can find the link and post it that would be appreciated.

RFK Jr. posted this tweet about Trump and covid. Apparently, IMHO, he is not a serious candidate (see this thread posted today POL - RFK Jr Considering Aaron Rodgers, Jesse Ventura As Potential Running Mates ) but still interesting that he's willing to debate the vaccine with both candidates.

View attachment 465094
Here you go


View: https://twitter.com/RobertKennedyJr/status/1766157635295105491?s=20
 

Heliobas Disciple

TB Fanatic
View: https://www.youtube.com/watch?v=ZLUoX4YEjqk
Vit D research, definitive and significant
Dr. John Campbell
Mar 13, 2024
12 min 18 sec

Vitamin D supplementation has a protective effect, against the incidence of COVID-19 in RCT studies, OR 0.403, (95% IC 0.218, 0.747). In the RCTs performed on HCWs, the overall reduction in risk in the population supplemented with vitamin D was approximately 80% against the incidence of COVID-19 in analytical studies OR = 0.592, (95% IC 0.476–0.736). Against the incidence of COVID-19 ICU admission OR 0.317, (95% IC 0.147–0.680). Our meta-analysis suggests a definitive and significant association between the protective role of vitamin D and COVID-19 incidence and ICU admission. Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis (28th Feb 2024) Vitamin D, crucial roles. Bone homeostasis, muscle function, oncogenesis, immune response and metabolism. In the context of the COVID-19 Numerous researchers have tried to determine the role vitamin D in the immune response to the virus. Systematic review and meta-analysis, 15th May 2023 Preventive vitamin D supplementation, 16 publications N = 1,262,235 participants, A protective role in Incidence of COVID-19 Mortality Admission to intensive care units (ICUs). We calculated the Odds Ratios The assessment of potential bias and the evaluation of study quality will be conducted independently by two researchers. Extra information The majority of the effects of vitamin D are mediated by the VDR, which promotes the expression of genes containing specific DNA sequences and is expressed in almost all nucleated cells Approximately 3 percent of the human genome is under the control of 1,25-dihydroxyvitamin D Vitamin D has been observed to contribute to the synthesis of defensins, to be pivotal for enhancing the phagocytic activity, and to modulate the immune system response by regulating the inflammatory cascade.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


New nasal vaccine platform helps clear COVID-19 infections in an animal model
by Sam Sholtis, Pennsylvania State University
March 13, 2024


new-nasal-vaccine-plat.jpg

Single-particle analysis and cryo-EM reconstruction of the apo cage used for immunizations. (A) A representative cryo-EM micrograph of apo cage particles. (B) Examples of representative class averages from a 2D classification of the particles extracted from cryo-EM micrographs. (C) A reconstructed icosahedral map of the apo cage structure colored according to the estimated local resolution. Red numbers in gray boxes on the structural model indicate the two-, three- and fivefold symmetry axes of the dodecahedron. (D) A Fourier shell correlation (FSC) curve of the reconstructed map using gold-standard refinement in cryoSPARC. (E) An atomic model of the apo cage was built by applying icosahedral symmetry in ChimeraX to an asymmetric unit fitted to the density of the map shown in panel C. (F) A portion of the map covering a single monomer is rendered as a transparent surface, with the fitted model shown as a light blue cartoon with side chains represented as sticks. Credit: Microbiology Spectrum (2024). DOI: 10.1128/spectrum.04998-22


A newly developed intranasal vaccine candidate helps to clear COVID-19 infections more quickly than controls in pre-clinical testing, according to a recent study. The new vaccine platform relies on a protein scaffold that resembles a tiny wire-frame soccer ball, roughly the size and shape of a virus. When the surface of the scaffold is decorated with a portion of the spike protein from the SARS-CoV-2 virus—the same protein used in existing COVID-19 vaccines—and delivered via the nose, it induces an immune response in a rodent model.

A paper describing the study, led by researchers in the Huck Institutes of the Life Sciences at Penn State, was published recently in the journal Microbiology Spectrum. The study demonstrates proof-of-principle for the scaffold, called "SpyCage," as a potential new delivery system for safe and effective nasal vaccines.

While further study is needed to optimize the system to achieve full protection, the SpyCage platform could be easily adapted for use against a variety of respiratory viruses, according to the research team.

"Vaccination is a safe and effective method to reduce the impact of harmful infectious diseases and has been crucial to slowing the COVID-19 pandemic," said Scott Lindner, associate professor of biochemistry and molecular biology in the Eberly College of Science at Penn State and one of the leaders of the research team.

"To date, essentially all COVID-19 vaccines are delivered by an injection into muscle. While effective at reducing the severity of infection and associated symptoms, these vaccines do not completely prevent infection or transmission of the virus to others."


View: https://www.youtube.com/watch?v=DUob72Xhzz8
1 min 2 sec
Credit: Pennsylvania State University

According to the researchers, intramuscular vaccines induce a systemic immune response in the body, but do not induce a strong immune response in mucus membranes, like in the nose and airways. Protection in the body's mucus membranes, where the virus is first encountered, is essential to preventing infection and limiting transmission of respiratory viruses.

"An effective vaccine administered via the nose has the potential to induce a mucosal immune response as well as a systemic response," said Troy Sutton, assistant professor of veterinary and biomedical sciences at Penn State and a leader of the research team.

"We are developing and testing the SpyCage vaccine delivery system to try to create vaccines that do just that. If we can induce a robust immune response in the respiratory tract, thereby blocking infection and transmission, we may be able to slow the spread of airborne viruses and potentially end, or even prevent, a pandemic."

According to the researchers, candidate nasal vaccines that have been developed to date have used viral vectors or live-attenuated viruses and continue to have safety concerns, especially for the most vulnerable populations.

"The SpyCage protein scaffold looks similar enough to a virus to trick the immune system into mounting a response, but none of it is actually derived from a virus," Lindner said. "We make portions of the SARS-CoV-2 spike protein in the lab and permanently attach them to the surface of the SpyCage. The result is a nanoparticle that resembles the virus in size, shape and symmetry that can induce an immune response in our pre-clinical animal testing."

In their tests, when the SpyCage was loaded with the spike protein and administered via the nose, it induced an immune response helping to clear an infection more quickly than in unvaccinated animals or if the spike protein was administered on its own. If the two components—the SpyCage scaffold and the spike proteins—were administered together but not bound to each other, the researchers did not see an immune response or reduction of infection. They also tested the vaccine in conjunction with an adjuvant—a substance designed to enhance the efficacy of nasal vaccines—but did not see any significant improvement.

"It's clear that the SpyCage must be decorated with spike proteins to train the body's immune system, so that when it is exposed to the actual virus, it can quickly respond and more rapidly eliminate the virus," Lindner said. "The SpyCage vaccine platform must still be optimized to achieve the goal of preventing infections and transmission, and we are working to improve its efficacy."

The researchers explained that the SpyCage vaccine platform continues to be developed and is the subject of several patents and pending patent applications.

"More testing is required to confirm its safety and optimize its effectiveness," Sutton said. "However, because of its modular design and assembly, SpyCage can be easily adapted to make vaccines against other respiratory viruses and could provide a platform for rapid response vaccines for novel viruses in the future."

More information: Devanshi R. Patel et al, Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model, Microbiology Spectrum (2024). DOI: 10.1128/spectrum.04998-22
Provided by Pennsylvania State University
 

Heliobas Disciple

TB Fanatic
(fair use applies)


How low humidity could be a boon for viruses: Study finds excess ventilation may counteract public health interventions
by Isabel Swafford, Stanford University
March 13, 2024

New Stanford research adds to evidence that the seasonality of respiratory illnesses, like COVID-19 or the flu, can be linked to indoor humidity levels. The study, which found that ventilation reduces the presence of naturally occurring disinfectant compounds in airborne microdroplets, could add another dimension to public health approaches to seasonal viruses.

In reaction to the threat of COVID-19 and other viral, airborne respiratory infections, experts have recommended increased ventilation in hospitals, nursing homes, schools, and other public buildings.

However, new research from Stanford University suggests that excess ventilation can reduce relative humidity in a way that could counteract public health interventions targeting airborne viral infections. This work may help explain why, in many regions of the world, more people tend to get sick with airborne viruses in winter when heating systems dry out indoor air.

"Experts have long recommended indoor relative humidity of 40% to 60%, and now this research points to a significant benefit: humidity in this range naturally creates anti-viral compounds in the air's microdroplets," said Richard Zare, the Marguerite Blake Wilbur Professor in Natural Science and a professor of chemistry in the Stanford School of Humanities and Sciences.

Zare is the senior author of a paper about this work, published in Proceedings of the National Academy of Sciences. "This could lead to controlling indoor relative humidity in a way that could radically alter how we combat airborne viral infections," Zare added.

Previous research led by Zare revealed that hydrogen peroxide, a common disinfectant, can spontaneously form in water microdroplets. Now, the researchers have discovered that, as humidity increases, so does the concentration of hydrogen peroxide and other naturally occurring disinfectant agents in the air.

This new finding suggests that ventilation aimed at preventing the spread of disease—which tends to dry air out—could be counterproductive and reveals a possible mechanism for the increased number of cases of airborne viruses during the winter months when heating and ventilation are used more often. The study also highlights the possibly beneficial effects of increased humidity for reducing the spread of airborne viruses.


Floating disinfectants

Respiratory illnesses are spread via infected water droplets exhaled when someone coughs, sneezes, or even talks. But water microdroplets might be capable of killing viruses in exhaled droplets, thanks to the abundance of reactive oxygen species, like hydrogen peroxide, on their surfaces.

To better understand this potential, the researchers studied water microdroplets, around 11 microns in diameter, in a humidity-controlled environment. Using nuclear magnetic resonance and other analysis methods, they measured the concentration of hydrogen peroxide at different temperatures, humidity levels, droplet sizes, and atmospheres.

The results showed that when they increased the humidity from 15% to 50%, the concentration of hydrogen peroxide increased by a factor of 3.5. From 50% to 95%, the concentration leveled off. So, as humidity increases, so does the concentration of reactive oxygen species and their ability to disinfect.

"When you have low relative humidity, two things happen. One, you do not form these reactive oxygen species as much as you do at higher relative humidity," said Zare. "Number two, the droplet evaporates much more rapidly, and the virus is quite content to be in a dry state and floating around. It becomes very light, and it doesn't fall to the ground for a long time."

Zare is already working on further studies to understand better exactly how reactive species, such as hydrogen peroxide, could reduce the prevalence of viruses in the air. However, the current results suggest that humidity could be an important factor in controlling the spread of airborne viruses. As of now, however, humidity is not considered in disease control plans or recommendations.


To ventilate, or not to ventilate

The Centers for Disease Control and Prevention recommends that indoor spaces be ventilated enough to meet five "air changes" per hour. Here, one complete air change is defined as all of the air in a given space being pushed out or an equivalent amount of air being circulated in.

Following his latest study, Zare warns against only focusing on ventilation.

"I'm not against ventilation," said Zare, "But doing it five times per hour, particularly in the wintertime when the heat is on, means that you're drying out the air and lowering the relative humidity. We have shown that low relative humidity makes viruses and droplets much more viable, and they survive a lot longer."

In the winter, when the heat is turned on or when a space is being overventilated, Zare suggests using a humidifier to maintain levels around 40% to 60% humidity in addition to ventilating a space.

Looking ahead, Zare is collaborating with Bolei Chen of JiangHan University to test the effects of relative humidity and temperature on the viability of the SARS-CoV-2 virus in water droplets.

More information: Zare, Richard N., Dependence on relative humidity in the formation of reactive oxygen species in water droplets, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2315940121. doi.org/10.1073/pnas.2315940121
Provided by Stanford University
 

Heliobas Disciple

TB Fanatic
(fair use applies)


mRNA Technology For Vaccines Questionable! Emory University Finds mRNA Vaccines Unable To Induce SARS-CoV-2 Bone Marrow Long-Lived Plasma Cells
Nikhil Prasad Fact checked by:Thailand Medical News Team
Mar 14, 2024

Since the emergence of the COVID-19 pandemic, vaccines have been claimed as a pivotal tool in mitigating the spread of the virus and reducing the severity of illness. Among the various vaccine platforms developed, mRNA vaccines have garnered significant attention for their so-called innovative technology and rapid deployment though the technology has been understudied!

However, four years into the COVID-19 pandemic, we are learning that the vaccine so far has not stopped the transmission of the virus nor prevents anyone from getting infected. Rather, those that are controlling the COVID-19 narratives are now claiming that the COVID-19 vaccines prevent risk of disease severity and reduces risk of mortality…something that cannot be properly and accurately audited as figures can be easily manipulated.

Worryingly, more and more studies and case reports are emerging on the adverse effects of these vaccines especially the mRNa vaccines.

Thailand Medical News had covered on some of the these in our previous COVID-19 News articles:

https://www.thailandmedical.news/ne...ovid-19-mrna-vaccines-can-lead-to-arrhythmias

https://www.thailandmedical.news/ne...s-possibly-triggering-autoimmune-pancreatitis

https://www.thailandmedical.news/ne...hat-mrna-covid-19-vaccines-can-cause-lymphoma

https://www.thailandmedical.news/ne...-a-variety-of-post-vaccine-medical-conditions

https://www.thailandmedical.news/ne...use-new-onset-of-acute-interstitial-nephritis

https://www.thailandmedical.news/ne...us-system-inflammatory-demyelinating-diseases

https://www.thailandmedical.news/ne...-be-causing-a-silent-pandemic-of-liver-injury

https://www.thailandmedical.news/ne...igger-pots-in-many-with-underlying-conditions

https://www.thailandmedical.news/ne...g-cancer-treatments-progressing-other-cancers

https://www.thailandmedical.news/ne...-eventual-kidney-failure-and-possible-cancers

https://www.thailandmedical.news/ne...ng-at-site-of-pfizer-s-mrna-vaccine-injection


https://www.thailandmedical.news/ne...kaposi-sarcoma-in-immunocompetent-individuals

https://www.thailandmedical.news/ne...ger-new-onset-of-systemic-lupus-erythematosus

However, recent research conducted at Emory University in Georgia, USA, has raised questions about the long-term efficacy of mRNA vaccines in inducing durable immunity against SARS-CoV-2, the virus responsible for COVID-19.


Understanding Long-Term Immunity: The Importance of Long-Lived Plasma Cells (LLPCs)
At the heart of effective vaccination lies the generation of long-lived plasma cells (LLPCs), specialized immune cells capable of producing antibodies that provide enduring protection against pathogens. Traditionally, natural infections and conventional vaccines, such as those for influenza and tetanus, have been shown to induce LLPCs in the bone marrow, ensuring sustained immunity for decades.

However, the Emory University study sheds light on a notable discrepancy in the immune response elicited by mRNA vaccines for SARS-CoV-2.


Investigating mRNA Vaccine Efficacy: Emory University's Research Findings
The study, led by researchers at Emory University, enrolled 19 healthy adults who had received mRNA vaccines against SARS-CoV-2. Bone marrow aspirates were collected from participants at various intervals post-vaccination, ranging from 1.5 to 33 months. Through meticulous analysis, the researchers sought to examine the presence and distribution of SARS-CoV-2-specific antibody-secreting cells (ASCs) within the bone marrow compartments.


Surprising Discoveries: Exclusion of SARS-CoV-2-Specific ASCs from the LLPC Compartment
The findings of the study revealed a striking pattern: while influenza- and tetanus-specific ASCs were readily detected in the LLPC subset of the bone marrow, SARS-CoV-2-specific ASCs were predominantly excluded from this compartment. Despite the presence of SARS-CoV-2-specific ASCs in other subsets of the bone marrow, their exclusion from the LLPC compartment posed a significant challenge to the longevity of claimed immune protection conferred by mRNA vaccines.


Implications for Vaccine Development: Addressing the Limitations
The implications of these findings are profound, suggesting inherent limitations in the ability of current mRNA vaccine platforms to induce robust LLPC responses essential for long-term immunity. To overcome these limitations, researchers may need to explore novel approaches, such as optimizing vaccine regimens, engineering spike proteins to enhance immunogenicity, or developing vaccine adjuvants to promote LLPC formation.


Unraveling the Mechanisms: Insights into LLPC Maturation and Migration
Further research is warranted to unravel the intricate molecular mechanisms underlying the inability of mRNA vaccines to effectively induce LLPCs. Understanding the processes involved in LLPC maturation and migration to the bone marrow microenvironment is critical for informing the development of next-generation vaccines that can confer durable immunity against SARS-CoV-2 and other viral pathogens.


Impacts on Public Health Policy: Navigating Vaccine Distribution Strategies
The Emory University study underscores the importance of continued surveillance and evaluation of vaccine efficacy beyond the initial phase of immunization. Policymakers and public health officials must consider these findings when formulating vaccine distribution strategies and recommending booster doses to ensure sustained protection against COVID-19.

The plans by many pharmaceutical companies and health authorities to deploy mRNA technology into the development of vaccines for other pathogenic diseases and even cancer should be reconsidered as more studies are needed to assess the mechanisms of these mRNA vaccines and their efficacy and also their adverse effects.


Conclusion: A Call for Continued Research and Innovation in Vaccine Development
In conclusion, Emory University's research offers valuable insights into the challenges of achieving long-term immunity against SARS-CoV-2 with current mRNA vaccine technologies. By identifying the limitations in LLPC induction, scientists are better equipped to devise strategies for enhancing vaccine efficacy and durability. As the global community continues to confront the COVID-19 pandemic, ongoing research and innovation in vaccine development remain paramount in the fight against viral threats.

The study findings were published on a preprint server and is currently being peer reviewed for publication into the peer reviewed journal: Nature.

 

Heliobas Disciple

TB Fanatic
(fair use applies)


Complete antibody evasion is easy to evolve
Radagast
March 13, 2024

I have to explain one more thing about SARS2. What you see in other species, is that persistent coronavirus infections can suddenly take a dramatic shift. Most cats infected with the feline coronavirus will survive. However, in a handful of cases, the virus manages to evolve mutations that allow it to efficiently infect white blood cells. These versions of the virus are very bad at transmitting themselves to other cats, but for the individual cat unlucky enough to have its viral parasite develop these mutations, it’s generally a death sentence.

This matters, because in the past few months, we’ve seen most of the human population infected with a radically new version of SARS2, with a Spike protein that is essentially optimized for persistent infection. It will take a few months, before we know what the long term outcome is of that.

Most of the antibodies people developed against the Receptor Binding Domain don’t manage to neutralize the new Spike protein, but they will prohibit the immune system from developing a better antibody response that would neutralize viral particles.

So neutralization of viral particles now depends on antibodies binding to the N-Terminal Domain. There are different ways to escape these antibodies. It’s possible through deletions in the three immunogenic loops, roughly corresponding to these amino acids: 14-26 (N1), 141-156 (N3) and 246-260 (N5).

But there are other ways to achieve it too. Proteins consist of long chains of amino acids. Cysteine is one of those amino acids, it helps determine the shape of the overall protein, because two cysteine amino acids in different places in the protein will be attracted to each other and form a bridge. This means that if either of those cysteine amino acids is changed by mutation to some other amino acid, the shape of a whole protein can change as a result.

With SARS2, we have already seen a version emerge that needed just two mutations, one blocking a cysteine in one place and the other adding a new cysteine in a whole other place, to lead to a version of the virus against which none of the NTD antibodies neutralized the virus anymore.

As far as I am aware, neutralizing antibodies that still work against the BA.2.86* Spike (including JN.1), are almost all antibodies against the NTD. Well, as you can see here, by making one cysteine inaccessible and adding another cysteine, the virus can avoid basically all those neutralizing antibodies:

1cysteine1-1024x1018.jpg
1cysteine2-1024x790.jpg


What this shows is that there are a bunch of different mutations, that make the cysteine at position 15 inaccessible. The virus can change position 12, it can change position 13, or it can just get rid of the cysteine at 15 altogether. Any of these options work.

Then it needs to add a different cysteine elsewhere, for the cysteine at 136 to bind to. In this case, it added cysteine at position 152. This was seen in a variant called B.1.640*, which was circulating together with Delta back in 2021, until everything was wiped out by Omicron. It was very good at fusing cells together and it looks like humanity basically dodged a bullet, thanks to Omicron wiping all these lineages out. You have to wonder if nature was feeling merciful, or whether humans themselves hurried to come up with a way to kick the can down the hall. It’s not unthinkable.

But there is basically nothing stopping changes like this from emerging again. And as the B.1.640 case shows, these versions may be perfectly capable of transmitting from one person to another.

Immunity is complex, there are so many variables involved that the whole thing can start to look like a connect the dots puzzle where you choose what you want to draw. But there are a few things we can say:

  1. Vaccination produces abnormally high concentrations of antibodies, to protect the population.
  2. Immunity in people as a result depends very strongly on these antibodies.
  3. The Receptor Binding Domain changes rapidly to avoid these antibodies. This forces the immune system to resort to neutralizing antibodies against the N-Terminal Domain.
  4. It takes a total of two amino acid changes, to avoid all neutralizing antibodies against the N-Terminal Domain.
So what you would expect is as following: In vaccinated people, T cells rapidly recruit B cells to start producing antibodies against the JN.1 Spike. These antibodies will be bad at neutralizing Spike through the receptor binding domain, because of the Original Antigenic Sin problem. It will be even worse when the B cells recruited produce an IgG4 response.

Concentrations of antibodies against the N-Terminal Domain rise greatly too however. These antibodies provide neutralization that clears the virus. Great! That is at least, until you remember: Two amino acid changes are sufficient to overcome all of them.

Breakthrough infections don’t solve this problem. Instead, what they do is they rearrange the immune system, by constantly recalling a particular adaptive response, that was originally induced by the vaccines. Because this adaptive response can fail suddenly and dramatically, as I have now illustrated to you, breakthrough infections don’t solve the problem, they make it worse. There’s a serious and growing risk the antibodies against SARS2 start interfering in the immune response against other pathogens too, because they are continually being recalled and the B cells undergo somatic hypermutation to slightly change their antibodies for new versions of the virus.

So if we already came strangely close to this doomsday scenario, why hasn’t it happened yet and why doesn’t that mean that it will never happen? Because in the past there were still other more obvious ways forward. The most important way forward, was to improve ACE2 affinity. This makes the virus intrinsically more infectious, so it spreads more easily. In addition, it can escape a bunch of antibodies through affinity escape. When the Spike binds stronger to the ACE2 receptor than an antibody does, antibodies can be evaded in that manner too.

But you can expect that there are just certain molecular limits to ACE2 affinity. With very high affinity, the Spike would probably bind to other stuff like red blood cells, before finding the ACE2 molecule. It doesn’t matter if you can theoretically bind strongly to ACE2, if you never get the chance because you’re already stuck on a red blood cell! They create these synthetic spikes in petri dishes with extremely high affinity, stronger than the most potent antibodies, but it’s doubtful they would be viable. You also have to wonder whether they would inadvertently kill the host cell before a viral particle can ever assemble.

So, although BA.2.86 had the highest ACE2 affinity ever seen so far, resulting in the most infectious version of the virus ever, that pattern just can not continue forever. Simple logic dictates that the struggle for survival will now force the virus to embark on different strategies. The most obvious path available now would be to get rid of all those antibodies binding to the NTD. That can happen through a bunch of deletions. But as I just showed you, it can be accomplished with just two amino acid mutations too.

This has already gotten much longer than I had intended it to be, but my point is: The evidence we have reveals that trying to protect people against this virus through an antibody response is a poor strategy, that can fail very suddenly and dramatically, both at an individual level, as well as at the level of entire populations. It doesn’t have to take more than two amino acids.


COMMENTS - SOME OF THEM, you should also recognize the name Igor Chudov, I post from his substack often

Radagast [author of this piece]
March 13, 2024 at 8:34 pm

I realised there’s something else I have never properly addressed. Severe SARS-COV-2 is generally associated with superimposed bacterial infections.

The NK cells that normally proliferate after a natural infection should generally be able to kill those bacteria too.

When CD8 T cells are doing the killing, they’re not going to kill those bacteria


Igor Chudov
March 14, 2024 at 12:31 am

I am also sitting around and waiting for the predicted evolution of Sars-Cov-2 into a “highly pathogenic virus.”

Frustratingly it remains not so pathogenic.

That said, a young man in his 20s (not my relative for those following me), had a “bad cold” in January and now he is having bad lower airway bronchitis and is taking strong antibiotics. So there’s that


Radagast
March 14, 2024 at 1:44 am

>"Frustratingly it remains not so pathogenic."

Careful what you wish for. There was a huge plunge in virulence from Delta to Omicron, but it has been getting steadily more pathogenic since then.
 
Last edited:

Heliobas Disciple

TB Fanatic
(fair use applies)


South Carolina’s top public health doctor warns senators wrong lessons being learned from COVID
By JEFFREY COLLINS
March 14, 2024

COLUMBIA, S.C. (AP) — South Carolina’s top doctor came before a small group of state senators on Thursday to tell them he thinks a bill overhauling how public health emergencies are handled in the wake of the COVID-19 pandemic has some bad ideas, concerns echoed by Gov. Henry McMaster.

As drafted, the bill would prevent mandating vaccines unless they have been licensed by the Food and Drug Administration for 10 years. That means that health care providers would be blocked from requiring flu vaccines or other shots that get yearly updates for ever-changing viruses, said Dr. Edward Simmer, director of the state Department of Health and Environmental Control.

In addition to loosening restrictions on who can visit people in isolation, the measure would also require symptom-free patients to be released from quarantine well before some infectious diseases begin to show outward signs, Simmer said at a Thursday hearing.

“There are a number of issues that we believe where this bill would cause harm to the people of South Carolina and would in fact cause unnecessary death amongst people of South Carolina during a public health crisis because it would prevent us from taking actions that could save lives,” Simmer said.

Friday is the last day US consumers can place mail orders for free COVID tests from the government

The bill passed the Senate subcommittee on a 4-3 vote, but with eight weeks to go in the General Assembly’s session, it still has to get through the body’s Medical Affairs Committee and a vote on the Senate floor before it can even be sent to the House.

In a further sign of the hurdles the bill faces, McMaster sent the subcommittee a letter saying “placing overbroad restrictions on the authority of public health officials, law enforcement officers, first responders, and emergency management professionals responding to emerging threats and disasters—whether public health or otherwise — is a bad idea.”

A similar subcommittee met in September, where many speakers sewed doubt about vaccine safety and efficacy, as well as distrust in the scientific establishment.

Members on Thursday listened to Simmer and took up some amendments on his concern and promised to discuss his other worries with the bill.

“You are making some good points, Dr. Simmer. I’m writing them all down,” Republican Sen. Richard Cash of Powdersville said.

The proposal would require health officials to release someone from quarantine if they didn’t show symptoms for five days. Simmers said people with diseases like measles, meningitis, bird flu and Ebola are contagious, but may not show symptoms for a week or more.

“I don’t think we would want after 10 days to release a person known to be infected with Ebola into the public,” Simmer said.

Supporters of the bill said they weren’t happy that during the start of the COVID-19 pandemic hospitals and nursing homes put patients into isolation. Allowing quicker releases from isolation and letting more people to visit someone in quarantine was a response to that issue.

Cash told Simmer that when the pandemic shutdown started, his wife had just endured a 17-hour cancer surgery and he was ordered to leave her bedside.

“Whatever she’s got, I got. But I still had to go,” Cash said.

Simmer said those decisions were made by the private nursing homes, hospitals and health care facilities. He said he had sympathy for decisions that had to be made quickly without much data, but he thought they were still wrong and pointed out the state didn’t order anyone to take a vaccine or isolate entire facilities.

“We saw the pictures of people seeing nursing home patients through a window. They should have been allowed in,” Simmer said. “When that didn’t happen that was a mistake. That was a lesson learned from COVID.”

Simmer asked lawmakers to pay attention to what actually happened during the pandemic and not just what they think happened.

“If this bill is designed to address concerns about COVID, we should recognize what did and did not happen during the pandemic,” Simmer said.
 
Top