Some *great* info at this website, some of which might help explain the sudden deaths of "healthy" people recently being reported in the news.
There is a LOT more info at the link below, many more links to each item with greater detail, as well as a few illustrations.
Fair use cited...
https://selfhacked.com/blog/supplem...e-tnf-interleukin-6-il-6/#TNF-alphaIncreasers
How To Increase Performance and Improve Health By Inhibiting TNF-alpha
Cytokines Updated: Oct 26, 2017
Top 16 Ways To Inhibit TNF
*Elemental diet (R)/ Lectin avoidance diet if lectin sensitive
*Fish Oil/DHA+EPA (R)
*Calorie restriction (R)
*Fasting (R)
*Exercise (R)
*PQQ (R)
*Resveratrol (R)
*Curcumin (R)…powerful (R)
*EGCG (R)
*Cinnamon/Sodium Benzoate (R, R2)
*Black Cumin Seed Oil….powerful (R)
*Rooibos (R)
*Carob (R)
*Licorice (R)
*Nicotinamide Riboside NAD+ (R)
*Kombucha/Lactic acid (R)
*Hops (xanthohumol) (R)…potent.
You can check if your fatigue, mood, and motivation issues are related to TNF by measuring blood TNF-alpha levels.
An Introduction to Tumor Necrosis Factor (TNF)
<Illustration at website linked above>
The three most common inflammatory cytokines that are responsible for chronic inflammatory diseases are Tumor Necrosis Factor (TNF), Interleukin-1beta (IL-1b) and Interleukin-6 (IL-6). These are the most commonly talked about cytokines in the literature.
The transcription factor nuclear factor NF-kappaB is also heavily spoken about and these four proteins are what people most likely refer to when they talk about chronic inflammation (whether they are aware of this or not).
TNF can be increased in either Th1 dominance or Th2 dominance.
TNF increases CRP, which is a common blood measurement to gauge inflammation. However, CRP is not sensitive enough to detect lower, but chronic levels of TNF. See my discussion of this in my IL-6 post.
It’s important to realize that you can have TNF elevated locally in areas such as your hypothalamus or gut and it wouldn’t show on blood tests.
Many kinds of cells release TNF and then TNF goes on to stimulate other immune cells.
TNF is released by Macrophages, Dendritic cells, T cells, Fat cells, and Fibroblasts.
TNF then affects various cells. In particular, it will affect cells that line our blood vessels (endothelial cells), which causes vascular problems and this strongly causes cancer, as it causes angiogenesis and increased blood vessel formation (hypervascularization). It can also cause heart disease, kidney disease, and cognitive problems.
TNF negatively affects intestinal cells, causing cell death, leaky gut, IBS, and IBD.
TNF stimulates macrophages and effector T cells, which leads to more inflammatory cytokine production and apoptosis resistance (which contributes to cancer).
There is a LOT more info at the link below, many more links to each item with greater detail, as well as a few illustrations.
Fair use cited...
https://selfhacked.com/blog/supplem...e-tnf-interleukin-6-il-6/#TNF-alphaIncreasers
How To Increase Performance and Improve Health By Inhibiting TNF-alpha
Cytokines Updated: Oct 26, 2017
Top 16 Ways To Inhibit TNF
*Elemental diet (R)/ Lectin avoidance diet if lectin sensitive
*Fish Oil/DHA+EPA (R)
*Calorie restriction (R)
*Fasting (R)
*Exercise (R)
*PQQ (R)
*Resveratrol (R)
*Curcumin (R)…powerful (R)
*EGCG (R)
*Cinnamon/Sodium Benzoate (R, R2)
*Black Cumin Seed Oil….powerful (R)
*Rooibos (R)
*Carob (R)
*Licorice (R)
*Nicotinamide Riboside NAD+ (R)
*Kombucha/Lactic acid (R)
*Hops (xanthohumol) (R)…potent.
You can check if your fatigue, mood, and motivation issues are related to TNF by measuring blood TNF-alpha levels.
An Introduction to Tumor Necrosis Factor (TNF)
<Illustration at website linked above>
The three most common inflammatory cytokines that are responsible for chronic inflammatory diseases are Tumor Necrosis Factor (TNF), Interleukin-1beta (IL-1b) and Interleukin-6 (IL-6). These are the most commonly talked about cytokines in the literature.
The transcription factor nuclear factor NF-kappaB is also heavily spoken about and these four proteins are what people most likely refer to when they talk about chronic inflammation (whether they are aware of this or not).
TNF can be increased in either Th1 dominance or Th2 dominance.
TNF increases CRP, which is a common blood measurement to gauge inflammation. However, CRP is not sensitive enough to detect lower, but chronic levels of TNF. See my discussion of this in my IL-6 post.
It’s important to realize that you can have TNF elevated locally in areas such as your hypothalamus or gut and it wouldn’t show on blood tests.
Many kinds of cells release TNF and then TNF goes on to stimulate other immune cells.
TNF is released by Macrophages, Dendritic cells, T cells, Fat cells, and Fibroblasts.
TNF then affects various cells. In particular, it will affect cells that line our blood vessels (endothelial cells), which causes vascular problems and this strongly causes cancer, as it causes angiogenesis and increased blood vessel formation (hypervascularization). It can also cause heart disease, kidney disease, and cognitive problems.
TNF negatively affects intestinal cells, causing cell death, leaky gut, IBS, and IBD.
TNF stimulates macrophages and effector T cells, which leads to more inflammatory cytokine production and apoptosis resistance (which contributes to cancer).