MNKYPOX Monkeypox - Consolidated Thread.
- Thread starter Tigerlily
- Start date
They say the old smallpox vaccines work.
naegling62
Veteran Member
Quick, someone get these folks some free transportation to D.C..
somewherepress
Has No Life - Lives on TB
Disclose.tv
@disclosetv
JUST IN - G7 health ministers to take part in a pandemic exercise in Germany, simulating a fast-spreading and dangerous outbreak of a "smallpox virus" originating from leopards, BILD reports.
View: https://twitter.com/disclosetv/status/1527057133153419264
Replying to
@disclosetv
Upcoming G7 health ministers virus exercise: "A leopard bites a human and transmits a dangerous smallpox virus."
bild.de
Pandemie-Szenario „Leopard-Pocken“: Gesundheitsminister proben für den Ernstfall
Anfang 2020 traf die Corona-Pandemie die ganze Welt völlig unvorbereitet. Es fehlte kurzfristig an Masken, Kitteln und
View: https://twitter.com/disclosetv/status/1527057133153419264
@disclosetv
JUST IN - G7 health ministers to take part in a pandemic exercise in Germany, simulating a fast-spreading and dangerous outbreak of a "smallpox virus" originating from leopards, BILD reports.
View: https://twitter.com/disclosetv/status/1527057133153419264
Replying to
@disclosetv
Upcoming G7 health ministers virus exercise: "A leopard bites a human and transmits a dangerous smallpox virus."
bild.de
Pandemie-Szenario „Leopard-Pocken“: Gesundheitsminister proben für den Ernstfall
Anfang 2020 traf die Corona-Pandemie die ganze Welt völlig unvorbereitet. Es fehlte kurzfristig an Masken, Kitteln und
View: https://twitter.com/disclosetv/status/1527057133153419264
Hawkgirl_70
Veteran Member
Why wouldn’t they just game out the Monkeypox instead since it’s now out there???
Roger Thornhill
Some irascible old curmudgeon
I'm quite happy that purple pitcher plants carpet the woods in every corner of my state.
bassaholic
Veteran Member
I see what they did there.
Tristan
Has No Life - Lives on TB
Faytuks Δ
@Faytuks
BREAKING: The number of patients treated for suspected Monkeypox in the last two days in Madrid is "between 40 and 50", hospital sources tell El Pais "the flow of patients to the emergency services has not stopped"
View: https://twitter.com/Faytuks/status/1527038807509458944
4:29 PM · May 18, 2022
Simply f'n charming.
One of our dear departed prognosticators seems to have 'called it'
Tristan
Has No Life - Lives on TB
Tristan
Has No Life - Lives on TB
TammyinWI
Talk is cheap
And how convenient...where did I just read it: a vaccine for smallpox and monkeypox was patented not too long ago...and not only that, I saw two young, slender guys walking down the street the other day holding hands, as in: the attempted "new normal" is supposed to include sodomy, and the did make some ground on that...
FDA approves first live, non-replicating vaccine to prevent smallpox and monkeypox
September 24, 2019
www.fda.gov
FDA approves first live, non-replicating vaccine to prevent smallpox and monkeypox
September 24, 2019
FDA approves first live, non-replicating vaccine to prevent smallpox and monkeypox
FDA announced approval of Jynneos for the prevention of smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk
Thunderdragon
Senior Member
Clif High and others nailed Covid prevention early on... Anyone seen anything similar on Monkeypox - besides washing your hands, not touching eyes, small pox vaccination, etc?
Tigerlily
Senior Member
You might want to go harvest them, and sell them.
night driver
ESFP adrift in INTJ sea
TammyinWI
Talk is cheap
Attempted capabilities and attempted outbreak. I have hope that their evil plans will not succeed like they want, after all, a lot of them have not!
night driver
ESFP adrift in INTJ sea
The "vid" == "(co)vid"
greysage
On The Level
Yes.
night driver
ESFP adrift in INTJ sea
Yeah, THIS stuff IS airborne (well 90 hours viable in air) so masks (GOOD ones, not stupid fakes) will be a LARGE help.
Oh the gay connection is NOT even a solid suspicion, since the LGBT clinics involved (Turd Whirled areas primarily) just happen to be more aware of things than the rest of us. The gay connection won't stand up to more effective scrutiny.
And TRUST ME I am NOT looking forward to living in N-95 or N-100 masks every out-of-the-house hour.
Worked like that for enough time to swear nevah ahgin!!
Damn how things happen
Oh the gay connection is NOT even a solid suspicion, since the LGBT clinics involved (Turd Whirled areas primarily) just happen to be more aware of things than the rest of us. The gay connection won't stand up to more effective scrutiny.
And TRUST ME I am NOT looking forward to living in N-95 or N-100 masks every out-of-the-house hour.
Worked like that for enough time to swear nevah ahgin!!
Damn how things happen
bassaholic
Veteran Member
Like Gates said, the next one will get our attention.
Heliobas Disciple
TB Fanatic
Here is the press release from the WHO. The same WHO which may control health response all over the globe if they get the amendments they want in the next week or two...
(fair use applies)
Monkeypox - United Kingdom of Great Britain and Northern Ireland
18 May 2022
Situation at a glance
On 13 May 2022, WHO was notified of two laboratory confirmed cases and one probable case of monkeypox, from the same household, in the United Kingdom. On 15 May, four additional laboratory confirmed cases have been reported amongst Sexual Health Services attendees presenting with a vesicular rash illness and in gay, bisexual, and other men who have sex with men (GBMSM).
As response measures, an incident team has been established to coordinate contact tracing efforts.
In contrast to sporadic cases with travel links to endemic countries (see Disease outbreak news on Monkeypox in the United Kingdom published on 16 May 2022), no source of infection has been confirmed yet. Based on currently available information, infection seems to have been locally acquired in the United Kingdom. The extent of local transmission is unclear at this stage and there is the possibility of identification of further cases.
Description of the cases
On 13 May 2022, the United Kingdom notified WHO of two laboratory confirmed cases and one probable case of monkeypox to WHO. All three cases belong to the same family.
The probable case is epidemiologically linked to the two confirmed cases and has fully recovered. The first case identified (index case) developed a rash on 5 May and was admitted to hospital in London, the United Kingdom on 6 May. On 9 May, the case was transferred to a specialist infectious disease centre for ongoing care. Monkeypox was confirmed on 12 May. Another confirmed case developed a vesicular rash on 30 April, confirmed to have monkeypox on 13 May, and is in a stable condition.
The West African clade of monkeypox was identified in the two confirmed cases using reverse transcriptase polymerase chain reaction (RT PCR) on vesicle swabs on 12 May and 13 May.
On 15 May, WHO was notified of four additional laboratory confirmed cases, all identified among GBMSM attending Sexual Health Services and presenting with a vesicular rash. All four were confirmed to have the West African clade of the monkeypox virus.
Epidemiology of the disease
Monkeypox is a sylvatic zoonosis with incidental human infections that usually occur in forested parts of Central and West Africa. It is caused by the monkeypox virus which belongs to the orthopoxvirus family. Monkeypox can be transmitted by droplet exposure via exhaled large droplets and by contact with infected skin lesions or contaminated materials. The incubation period of monkeypox is usually from 6 to 13 days but can range from 5 to 21 days. The disease is often self-limiting with symptoms usually resolving spontaneously within 14 to 21 days. Symptoms can be mild or severe, and lesions can be very itchy or painful. The animal reservoir remains unknown, although is likely to be among rodents. Contact with live and dead animals through hunting and consumption of wild game or bush meat are known risk factors.
There are two clades of monkeypox virus: the West African clade and Congo Basin (Central African) clade. Although the West African clade of monkeypox virus infection sometimes leads to severe illness in some individuals, disease is usually self-limiting. The case fatality ratio for the West African clade has been documented to be around 1%, whereas for the Congo Basin clade, it may be as high as 10%. Children are also at higher risk, and monkeypox during pregnancy may lead to complications, congenital monkeypox or stillbirth.
Milder cases of monkeypox may go undetected and represent a risk of person-to-person transmission. There is likely to be little immunity to the infection in those travelling or otherwise exposed, as endemic disease is normally geographically limited to parts of West and Central Africa. Historically, vaccination against smallpox was shown to be protective against monkeypox. While one vaccine (MVA-BN) and one specific treatment (tecovirimat) were approved for monkeypox, in 2019 and 2022 respectively, these countermeasures are not yet widely available, and populations worldwide under the age of 40 or 50 years no longer benefit from the protection afforded by prior smallpox vaccination programmes.
Public health response
Health authorities in the United Kingdom have established an incident management team to coordinate the extensive contact tracing which is currently underway in health care settings and the community for those who have had contact with the confirmed cases. Contacts are being assessed based on their level of exposure and followed up through active or passive surveillance for 21 days from the date of last exposure to a case. Vaccination is being offered to higher risk contacts.
A detailed backwards contact tracing investigation is also being carried out to determine the likely route of acquisition and establish whether there are any further chains of transmission within the United Kingdom for all cases. Sexual contacts and venues visited (for example saunas, bars and clubs) are actively being investigated for the four GBMSM cases.
WHO risk assessment
No source of infection has yet been confirmed for either the family or GBMSM clusters. Based on currently available information, infection seems to have been locally acquired in the United Kingdom. The extent of local transmission is unclear at this stage and there is the possibility of identification of further cases. However, once monkeypox was suspected, authorities in the United Kingdom promptly initiated appropriate public health measures, including isolation of the cases and extensive forward and backward contact tracing to enable source identification.
In the United Kingdom, there have been eight previous cases of monkeypox reported: all importations were related to a travel history to or from Nigeria. In 2021, there were also two separate human monkeypox cases imported from Nigeria reported by the United States of America. During an outbreak of monkeypox in humans in 2003 in the United States of America, exposure was traced to contact with pet prairie dogs that had been co-housed with monkeypoxvirus-infected small mammals imported from Ghana.
WHO advice
Intensive public health measures should continue in the United Kingdom. In addition to the ongoing forward and backward contact tracing and source tracing, case searching, and local rash-illness surveillance should be strengthened in the GBMSM and wider community, as well as in primary and secondary health care settings. Any patient with suspected monkeypox should be investigated and isolated with supportive care during the presumed and known infectious periods, that is, during the prodromal and rash stages of the illness, respectively. Timely contact tracing, surveillance measures and raising awareness among health care providers, including sexual health and dermatology clinics, are essential for preventing further secondary cases and effective management of the current outbreak. Additionally, deployment of pharmaceutical countermeasures under investigational protocols can be considered.
Health workers and other care givers caring for patients with suspected or confirmed monkeypox should implement standard, contact and droplet infection control precautions. Samples taken from people with suspected monkeypox or animals with suspected monkeypox virus infection should be safely handled by trained staff working in suitably equipped laboratories.
Any illness during travel or upon return from an endemic area should be reported to a health professional, including information about all recent travel and immunization history. Residents and travellers to endemic countries should avoid contact with sick animals (dead or alive) that could harbour monkeypox virus (rodents, marsupials, primates) and should refrain from eating or handling wild game (bush meat). The importance of hand hygiene by using soap and water or alcohol-based sanitizer should be emphasized.
International travel or trade: WHO does not recommend any restriction for travel to and trade with the United Kingdom based on available information at this time.
WHO continue to closely monitor as the situation is evolving rapidly.
Further information
- WHO factsheet on monkeypox.
- WHO monkeypox outbreak tool kit.
- The UK Health Security Agency News story on 16 May 2022, Monkeypox cases confirmed in England – latest updates
- WHO disease outbreak news, monkeypox, United Kingdom of Great Britain and Northern Ireland, 16 May 2022.
- WHO disease outbreak news, monkeypox, United Kingdom of Great Britain and Northern Ireland, 8 July2021.
- WHO disease outbreak news, monkeypox, all items.
- Weekly epidemiological record (WER) no.11, 16 March 2018, Emergence of monkeypox in West Africa and Central Africa 1970-2017.
- Nigeria Centre for Disease Control. Monkeypox.
- Monkeypox in the United States of America.
- OpenWHO. Monkeypox: Introduction. Online training module. 2020. English Français
- OpenWHO. Monkeypox epidemiology, preparedness and response. Extended training. 2021. English Français
night driver
ESFP adrift in INTJ sea
At least with this, there won't be much question on whether or not someone HAS it. At least not after the 21 day incubation period.
I haven't seen where in that period that one becomes infectious. THAT may be a VERY important piece we need soonest.
I haven't seen where in that period that one becomes infectious. THAT may be a VERY important piece we need soonest.
jward
passin' thru
Vanessa Blakeslee
@vmblakeslee
6m
Guess a few at the top saw Mad Max Sri Lanka and the incoming global food riots and said, "Quick, release the monkey pox!" Just in time for the creepy WHO treaty, too. So blatant, desperate, and unimaginative. But I guess the
View: https://twitter.com/vmblakeslee/status/1527101613164437504?s=20&t=AKgm4CZ4t8jLPpCmSvc9-A
jward
passin' thru
As of today, Flu trackers is still posting info strongly suggesting that the gay and bisexual communities are in particular need of awareness so standing up thus far
Today, 01:28 PM
Monkeypox cases confirmed in England – latest updates
Latest updates on cases of monkeypox identified by the UK Health Security Agency (UKHSA).
From:UK Health Security Agency
Published 14 May 2022
Last updated 18 May 2022 — See all updates
Latest
Two more cases of monkeypox identified by UKHSA
The UK Health Security Agency (UKHSA) has detected 2 additional cases of monkeypox, one in London and one in the South East of England.
The latest cases bring the total number of monkeypox cases confirmed in England since 6 May to 9, with recent cases predominantly in gay, bisexual or men who have sex with men (MSM).
The 2 latest cases have no travel links to a country where monkeypox is endemic, so it is possible they acquired the infection through community transmission.
The virus spreads through close contact and UKHSA is advising individuals, particularly those who are gay, bisexual or MSM, to be alert to any unusual rashes or lesions on any part of their body, especially their genitalia, and to contact a sexual health service if they have concerns.
Monkeypox has not previously been described as a sexually transmitted infection, though it can be passed on by direct contact during sex. It can also be passed on through other close contact with a person who has monkeypox or contact with clothing or linens used by a person who has monkeypox.
The 2 new cases do not have known connections with previous confirmed cases announced on 16, 14 and 7 May.
UKHSA is working closely with the NHS and other stakeholders to urgently investigate where and how recent confirmed monkeypox cases were acquired, including how they may be linked to each other.
The virus does not usually spread easily between people. The risk to the UK population remains low.
Anyone with concerns that they could be infected with monkeypox is advised to contact NHS 111 or a sexual health clinic. People should notify clinics ahead of their visit. We can assure them their call or discussion will be treated sensitively and confidentially.
Monkeypox is a viral infection usually associated with travel to West Africa. It is usually a mild self-limiting illness, spread by very close contact with someone with monkeypox and most people recover within a few weeks.
Dr Susan Hopkins, Chief Medical Adviser, UKHSA, said:
These latest cases, together with reports of cases in countries across Europe, confirms our initial concerns that there could be spread of monkeypox within our communities.
UKHSA has quickly identified cases so far and we continue to rapidly investigate the source of these infections and raise awareness among healthcare professionals.
We are particularly urging men who are gay and bisexual to be aware of any unusual rashes or lesions and to contact a sexual health service without delay if they have concerns. Please contact clinics ahead of your visit.
We are contacting any identified close contacts of the cases to provide health information and advice.
Clinicians should be alert to individuals presenting with rashes without a clear alternative diagnosis and should contact specialist services for advice.
Symptoms
Initial symptoms of monkeypox include fever, headache, muscle aches, backache, swollen lymph nodes, chills and exhaustion. A rash can develop, often beginning on the face, then spreading to other parts of the body including the genitals.
The rash changes and goes through different stages, and can look like chickenpox or syphilis, before finally forming a scab, which later falls off.
Today, 01:28 PM
Monkeypox cases confirmed in England – latest updates
Latest updates on cases of monkeypox identified by the UK Health Security Agency (UKHSA).
From:UK Health Security Agency
Published 14 May 2022
Last updated 18 May 2022 — See all updates
Latest
Two more cases of monkeypox identified by UKHSA
The UK Health Security Agency (UKHSA) has detected 2 additional cases of monkeypox, one in London and one in the South East of England.
The latest cases bring the total number of monkeypox cases confirmed in England since 6 May to 9, with recent cases predominantly in gay, bisexual or men who have sex with men (MSM).
The 2 latest cases have no travel links to a country where monkeypox is endemic, so it is possible they acquired the infection through community transmission.
The virus spreads through close contact and UKHSA is advising individuals, particularly those who are gay, bisexual or MSM, to be alert to any unusual rashes or lesions on any part of their body, especially their genitalia, and to contact a sexual health service if they have concerns.
Monkeypox has not previously been described as a sexually transmitted infection, though it can be passed on by direct contact during sex. It can also be passed on through other close contact with a person who has monkeypox or contact with clothing or linens used by a person who has monkeypox.
The 2 new cases do not have known connections with previous confirmed cases announced on 16, 14 and 7 May.
UKHSA is working closely with the NHS and other stakeholders to urgently investigate where and how recent confirmed monkeypox cases were acquired, including how they may be linked to each other.
The virus does not usually spread easily between people. The risk to the UK population remains low.
Anyone with concerns that they could be infected with monkeypox is advised to contact NHS 111 or a sexual health clinic. People should notify clinics ahead of their visit. We can assure them their call or discussion will be treated sensitively and confidentially.
Monkeypox is a viral infection usually associated with travel to West Africa. It is usually a mild self-limiting illness, spread by very close contact with someone with monkeypox and most people recover within a few weeks.
Dr Susan Hopkins, Chief Medical Adviser, UKHSA, said:
These latest cases, together with reports of cases in countries across Europe, confirms our initial concerns that there could be spread of monkeypox within our communities.
UKHSA has quickly identified cases so far and we continue to rapidly investigate the source of these infections and raise awareness among healthcare professionals.
We are particularly urging men who are gay and bisexual to be aware of any unusual rashes or lesions and to contact a sexual health service without delay if they have concerns. Please contact clinics ahead of your visit.
We are contacting any identified close contacts of the cases to provide health information and advice.
Clinicians should be alert to individuals presenting with rashes without a clear alternative diagnosis and should contact specialist services for advice.
Symptoms
Initial symptoms of monkeypox include fever, headache, muscle aches, backache, swollen lymph nodes, chills and exhaustion. A rash can develop, often beginning on the face, then spreading to other parts of the body including the genitals.
The rash changes and goes through different stages, and can look like chickenpox or syphilis, before finally forming a scab, which later falls off.
England: 2022 mpox cases - FluTrackers News and Information
England: 2022 mpox cases
flutrackers.com
jward
passin' thru
Additional thoughts from Flu-trackers
Thoughts on a global outbreak of monkeypox
Today, 06:38 PM
Well, another one of those days where I keep reading FT every few hours and asking myself how what I'm reading is possible. Monkeypox has now been reported domestically in the UK, Spain, Portugal, Canada, and a case in the US imported from Canada. If this really is a single outbreak due to efficient H2H spread, we're on the verge of something unthinkable. The problem is, if this were the case, I'd have expected more than the few dozen cases reported to this point. If the virus has really mutated to spread more efficiently H2H to cause this outbreak, a pandemic far worse than COVID-19 would be imminent.
So what are the other possible explanations? Could this not be an H2H outbreak at all? Could infected animals or animal products have been distributed throughout North America and Europe? One thing that has been running through my mind repeatedly today is the possibility of contaminated animal skin condoms having been distributed in multiple countries, explaining the possible sexual transmissions.
Could this be a bioterrorist attack, perhaps targeted at the LGBT communities in multiple nations? A group like Boko Haram might certainly be able to obtain this virus from an animal source, but coordinating an attack on multiple nations like this would be difficult? And what would be the method of dispersal? Spraying the virus in gay clubs?
Is it possible that this is a Russian bio-attack on NATO over the war in Ukraine? We know the Soviet Union weaponized the smallpox virus in the 1970s, so it's not too inconceivable there could have been work on monkeypox as well. But sequencing the virus should tell us relatively soon if this is similar to natural strains in West Africa, and if this is not, that would almost certainly trigger a World War. If the virus is indeed fully natural, this scenario seems unlikely simply because of the response it would trigger. My mind shudders at this explanation and its possible consequences almost as badly as it does the thought of the virus naturally going pandemic.
If this virus has indeed gained the ability to transmit more efficiently, whatever the method of mutation, the other question is why it keeps being detected in isolated cases and not large hospital clusters like the original SARS outbreak did. We have a large geographical spread of this outbreak, but not a huge number of cases.
The timing is also suspect here. All these cases have essentially the same onset date, not in generations a couple weeks apart as would be suspected if this were multiple generations of H2H spread from a point source like an importation or release.
Very odd....
One additional thought...if the sexual exposure really represents an H2H transmission, you should be able to contact trace; that is to ask the patients who they had sex with in the past two weeks, and presumably, you'd get only a short list of people who you could check to see if they had previously been ill. This would NOT be the case if an infected condom or something similar had the result of infecting one or both sexual partners during the act. I feel like the former type of contact tracing should have been done already, and the fact that it's not turning up chains of transmission might argue against H2H spread.
This is not HIV with a long incubation period to allow for silent transmission.
Thoughts on a global outbreak of monkeypox
Today, 06:38 PM
Well, another one of those days where I keep reading FT every few hours and asking myself how what I'm reading is possible. Monkeypox has now been reported domestically in the UK, Spain, Portugal, Canada, and a case in the US imported from Canada. If this really is a single outbreak due to efficient H2H spread, we're on the verge of something unthinkable. The problem is, if this were the case, I'd have expected more than the few dozen cases reported to this point. If the virus has really mutated to spread more efficiently H2H to cause this outbreak, a pandemic far worse than COVID-19 would be imminent.
So what are the other possible explanations? Could this not be an H2H outbreak at all? Could infected animals or animal products have been distributed throughout North America and Europe? One thing that has been running through my mind repeatedly today is the possibility of contaminated animal skin condoms having been distributed in multiple countries, explaining the possible sexual transmissions.
Could this be a bioterrorist attack, perhaps targeted at the LGBT communities in multiple nations? A group like Boko Haram might certainly be able to obtain this virus from an animal source, but coordinating an attack on multiple nations like this would be difficult? And what would be the method of dispersal? Spraying the virus in gay clubs?
Is it possible that this is a Russian bio-attack on NATO over the war in Ukraine? We know the Soviet Union weaponized the smallpox virus in the 1970s, so it's not too inconceivable there could have been work on monkeypox as well. But sequencing the virus should tell us relatively soon if this is similar to natural strains in West Africa, and if this is not, that would almost certainly trigger a World War. If the virus is indeed fully natural, this scenario seems unlikely simply because of the response it would trigger. My mind shudders at this explanation and its possible consequences almost as badly as it does the thought of the virus naturally going pandemic.
If this virus has indeed gained the ability to transmit more efficiently, whatever the method of mutation, the other question is why it keeps being detected in isolated cases and not large hospital clusters like the original SARS outbreak did. We have a large geographical spread of this outbreak, but not a huge number of cases.
The timing is also suspect here. All these cases have essentially the same onset date, not in generations a couple weeks apart as would be suspected if this were multiple generations of H2H spread from a point source like an importation or release.
Very odd....
One additional thought...if the sexual exposure really represents an H2H transmission, you should be able to contact trace; that is to ask the patients who they had sex with in the past two weeks, and presumably, you'd get only a short list of people who you could check to see if they had previously been ill. This would NOT be the case if an infected condom or something similar had the result of infecting one or both sexual partners during the act. I feel like the former type of contact tracing should have been done already, and the fact that it's not turning up chains of transmission might argue against H2H spread.
This is not HIV with a long incubation period to allow for silent transmission.
bassaholic
Veteran Member
And how convenient...where did I just read it: a vaccine for smallpox and monkeypox was patented not too long ago...and not only that, I saw two young, slender guys walking down the street the other day holding hands, as in: the attempted "new normal" is supposed to include sodomy, and the did make some ground on that...
FDA approves first live, non-replicating vaccine to prevent smallpox and monkeypox
September 24, 2019
FDA approves first live, non-replicating vaccine to prevent smallpox and monkeypox
FDA announced approval of Jynneos for the prevention of smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk
So the vax was conveniently approved late 2019. It’s not hard to see what’s coming our way.
jward
passin' thru
Helen Branswell also addressed the outbreaks today:
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak
By Helen Branswell May 18, 2022
Reprints
This highly magnified electron micrographic images shows a mulberry-type monkeypox virus particle. CDC
The United States confirmed a case of monkeypox infection on Wednesday in a man who recently traveled to Canada. It is not yet clear if the man, who lives in Massachusetts and who traveled to Canada by car, is connected to the growing outbreak of monkeypox cases in Europe.
The case was announced in a statement posted to the website of the Massachusetts Department of Public Health. Confirmatory testing was done by the Centers for Disease Control and Prevention, which had warned earlier Wednesday that cases in this country were likely to begin to be detected.
“Given that we have seen now confirmed cases out of Portugal, suspected cases out of Spain, we’re seeing this expansion of confirmed and suspect cases globally, we have a sense that no one has their arms around this to know how large and expansive it might be. And given how much travel there is between the United States and Europe, I am very confident we’re going to see cases in the United States,” said Jennifer McQuiston, deputy director of the CDC’s division of high consequence pathogens and pathology.
McQuiston said in an email Wednesday that it has not yet been determined if the Massachusetts case was part of the growing European outbreak.
The development adds the United States and possibly Canada to a growing list of countries reporting monkeypox cases in an outbreak first spotted in the United Kingdom. The Public Health Agency of Canada said in a statement late Wednesday that no cases have been reported at this time.
Maria Van Kerkhove, who leads the emerging diseases and zoonoses unit in the World Health Organization’s Health Emergencies Program, said Spain has now confirmed some cases and other countries will join this list.
“We have had positive cases identified in the U.K., Portugal, and Spain. And we expect there will be others,” Van Kerkhove told STAT on Wednesday.
Related:
CDC expresses concern about possibility of undetected monkeypox spread in U.K.
Earlier in the day Spain announced that it was investigating eight suspected cases, and Portugal said it was investigating more than 20 suspected cases, five of which have already been confirmed. It is not currently clear if the outbreaks are linked to each other or to the one in the U.K., where nine confirmed and one probable case have been reported.
If they are connected, it is not yet known if the virus spread from the U.K. to Europe, or the reverse. Nor is it known how long the virus has been spreading in these countries. “Clearly it’s been going on for a few weeks,” said Van Kerkhove.
Most of the cases have been detected in men who are gay, bisexual, or are men who have sex with men, she confirmed, but cautioned against over-focusing on that fact.
“We’re finding where we’re looking,” Van Kerkhove said, noting that countries have been contacting sexual health clinics asking about patients with unusual rashes. It is important that other health care providers in other settings — general practitioners, dermatologists, and others — are aware of the possibility they might see monkeypox cases so that if the virus is spreading more broadly, they take adequate precautions and those cases aren’t missed.
The details that have come to light so far raise the prospect of an outbreak that is even more geographically widespread, said Michael Osterholm, director of the University of Minnesota’s Center for Infectious Disease Research and Policy.
“There could be dynamic transmission here that we just haven’t appreciated because of the potential number of contacts,” he said, adding it will be important to collect information about how much intimate contact patients have had and where those contacts may have come from.
Tom Inglesby, director of the Center for Health Security at the Johns Hopkins Bloomberg School of Public Health, said a number of countries outside Central and West Africa, where monkeypox is more common, have experience coping with introductions of the virus, so there is a possibility that the outbreaks will be “relatively small.”
“I think that’s still probable, given the past,” Inglesby told STAT. “But on the other hand, this is starting off with much more of a foothold, in a much more distributed way, and we don’t understand how it got … into those networks.”
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“This could have the potential to move around and is going to require pretty strong public education efforts in affected communities and maybe even more broadly, so that people recognize the possibility” of monkeypox infection, he said.
The U.K. Health Security Agency announced Wednesday that it had detected two additional cases, bringing to nine the number reported there this month. Prior to this outbreak the U.K. had only ever detected seven monkeypox cases. The two latest cases had not traveled to the countries where monkeypox virus is endemic, and have no known links to any of the prior cases “so it is possible they acquired the infection through community transmission,” the agency said in a statement, adding that recent cases have been predominantly among men who identify as gay, bisexual, or who have sex with men.
The rapid accumulation of cases is ringing alarm bells.
On Tuesday, the CDC signaled it was worried about the state of the outbreak in the U.K. and the potential that cases would be found in other countries.
“We do have a level of concern that this is very different than what we typically think of from monkeypox,” McQuiston said. “We don’t understand how many other cases could be out there in the U.K., for example, with undefined chains of transmission. We have a sense that there might be some unusual methods of transmission, through intimate contact or some form of close personal contact that we’ve not previously associated with monkeypox.”
The WHO, which previously designated monkeypox as a priority pathogen, has organized a meeting of experts on monkeypox and orthopoxviruses — the wider family of pox viruses — for early next week. Among the issues the experts will likely tackle is an apparent change in the epidemiology of the disease in countries where the virus is endemic that has occurred in recent years.
“We’re seeing a shift in the age distribution of cases. We’re seeing a shift in the geographic distribution of cases,” said Michael Ryan, executive director of the WHO’s Health Emergencies Program. “We have to really understand that deep ecology. We have to really understand human behavior in those regions and we have to try to prevent the disease from reaching humans in the first place.”
The monkeypox virus is related to the variola virus, which caused smallpox, a once dreaded disease that was declared eradicated in 1980. The symptoms of monkeypox are similar to but milder than smallpox.
Infected people develop flu-like symptoms — fever, body aches, chills — but also swollen lymph nodes. With one to three days of the onset of fever, a distinctive rash appears, often starting on the face. Many conditions can cause rashes but the monkeypox rash has some unusual features, notably the fact that vesicles can form on the palms of the hands.
In countries where it is endemic, the virus is believed to mainly spread to people from infected animals when people kill or prepare bushmeat for consumption.
Once the virus jumps to people, human-to-human transmission can occur via respiratory droplets — virus-laced saliva that can infect the mucosal membranes of the eyes, nose, and throat — or by contact with monkeypox lesions or bodily fluids, with the virus entering through small cuts in the skin. It can also be transmitted by contact with clothing or linens contaminated with material from monkeypox lesions.
Cases outside of Africa have been rare, though there was a large outbreak in the United States in 2003 that involved 47 confirmed and probable cases in six states. That outbreak, the first reported from outside of Africa, was traced back to the importation of small mammals from Ghana.
However, in the past few years there has been small increases in exported monkeypox cases. The U.S. detected two in 2021, both in travelers who had returned from Nigeria. The U.K. has seen multiple importations in the past few years and Israel and Singapore have also detected cases.
McQuiston said the number of exported cases from Nigeria in particular appear to be at odds with the reported number of cases in the country itself.
“I think that we are concerned about the number of exported cases in travelers we’ve seen. And to have so many of them in the last few years is simply a flag to us that there’s a lot more monkeypox transmission happening in Nigeria than perhaps the [official] numbers would suggest,” she said.
“And I think it also is a flag to us that the more traditional routes of transmission that we think of such as hunting wild animals, contact with bushmeat, living at that interface between the jungle and small communities does not seem to be a driver of transmission in terms of what we see happening. And so that makes us cast a wider net about what risk factors might be.”
There is no licensed vaccine to protect against monkeypox, nor are there specific drugs for the disease. But it is believed that vaccines and drugs developed and stockpiled as a hedge against a return of smallpox are useful. In the 2003 outbreak in the U.S., smallpox vaccine was used.
The WHO’s Van Kerkhove noted that some of these products have been licensed using what is known as the animal rule, where animal efficacy data are used as a surrogate because the lack of circulating smallpox means the vaccines or drugs can’t be tested for efficacy in people. As a result, any such product could only be used in the context of a clinical trial, she said.
“There are options. We just have to make sure that they’re used appropriately. One of the things related to vaccines is we want to make sure if the vaccines are needed and used, they’re used among populations that need them the most. There’s not ample supply of anything right now,” she said.
Still, she expressed confidence the outbreak can be controlled.
“What we need to do right now is focus on stopping the spread. And we can do that. We can do that with the appropriate messaging, with the appropriate testing … with supportive isolation and clinical care as necessary, with protecting health workers,” Van Kerkhove said.
Helen Branswell
Senior Writer, Infectious Disease
Helen covers issues broadly related to infectious diseases, including outbreaks, preparedness, research, and vaccine development.
www.statnews.com
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak
By Helen Branswell May 18, 2022
Reprints
The United States confirmed a case of monkeypox infection on Wednesday in a man who recently traveled to Canada. It is not yet clear if the man, who lives in Massachusetts and who traveled to Canada by car, is connected to the growing outbreak of monkeypox cases in Europe.
The case was announced in a statement posted to the website of the Massachusetts Department of Public Health. Confirmatory testing was done by the Centers for Disease Control and Prevention, which had warned earlier Wednesday that cases in this country were likely to begin to be detected.
“Given that we have seen now confirmed cases out of Portugal, suspected cases out of Spain, we’re seeing this expansion of confirmed and suspect cases globally, we have a sense that no one has their arms around this to know how large and expansive it might be. And given how much travel there is between the United States and Europe, I am very confident we’re going to see cases in the United States,” said Jennifer McQuiston, deputy director of the CDC’s division of high consequence pathogens and pathology.
McQuiston said in an email Wednesday that it has not yet been determined if the Massachusetts case was part of the growing European outbreak.
The development adds the United States and possibly Canada to a growing list of countries reporting monkeypox cases in an outbreak first spotted in the United Kingdom. The Public Health Agency of Canada said in a statement late Wednesday that no cases have been reported at this time.
Maria Van Kerkhove, who leads the emerging diseases and zoonoses unit in the World Health Organization’s Health Emergencies Program, said Spain has now confirmed some cases and other countries will join this list.
“We have had positive cases identified in the U.K., Portugal, and Spain. And we expect there will be others,” Van Kerkhove told STAT on Wednesday.
Related:
CDC expresses concern about possibility of undetected monkeypox spread in U.K.
Earlier in the day Spain announced that it was investigating eight suspected cases, and Portugal said it was investigating more than 20 suspected cases, five of which have already been confirmed. It is not currently clear if the outbreaks are linked to each other or to the one in the U.K., where nine confirmed and one probable case have been reported.
If they are connected, it is not yet known if the virus spread from the U.K. to Europe, or the reverse. Nor is it known how long the virus has been spreading in these countries. “Clearly it’s been going on for a few weeks,” said Van Kerkhove.
Most of the cases have been detected in men who are gay, bisexual, or are men who have sex with men, she confirmed, but cautioned against over-focusing on that fact.
“We’re finding where we’re looking,” Van Kerkhove said, noting that countries have been contacting sexual health clinics asking about patients with unusual rashes. It is important that other health care providers in other settings — general practitioners, dermatologists, and others — are aware of the possibility they might see monkeypox cases so that if the virus is spreading more broadly, they take adequate precautions and those cases aren’t missed.
The details that have come to light so far raise the prospect of an outbreak that is even more geographically widespread, said Michael Osterholm, director of the University of Minnesota’s Center for Infectious Disease Research and Policy.
“There could be dynamic transmission here that we just haven’t appreciated because of the potential number of contacts,” he said, adding it will be important to collect information about how much intimate contact patients have had and where those contacts may have come from.
Tom Inglesby, director of the Center for Health Security at the Johns Hopkins Bloomberg School of Public Health, said a number of countries outside Central and West Africa, where monkeypox is more common, have experience coping with introductions of the virus, so there is a possibility that the outbreaks will be “relatively small.”
“I think that’s still probable, given the past,” Inglesby told STAT. “But on the other hand, this is starting off with much more of a foothold, in a much more distributed way, and we don’t understand how it got … into those networks.”
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“This could have the potential to move around and is going to require pretty strong public education efforts in affected communities and maybe even more broadly, so that people recognize the possibility” of monkeypox infection, he said.
The U.K. Health Security Agency announced Wednesday that it had detected two additional cases, bringing to nine the number reported there this month. Prior to this outbreak the U.K. had only ever detected seven monkeypox cases. The two latest cases had not traveled to the countries where monkeypox virus is endemic, and have no known links to any of the prior cases “so it is possible they acquired the infection through community transmission,” the agency said in a statement, adding that recent cases have been predominantly among men who identify as gay, bisexual, or who have sex with men.
The rapid accumulation of cases is ringing alarm bells.
On Tuesday, the CDC signaled it was worried about the state of the outbreak in the U.K. and the potential that cases would be found in other countries.
“We do have a level of concern that this is very different than what we typically think of from monkeypox,” McQuiston said. “We don’t understand how many other cases could be out there in the U.K., for example, with undefined chains of transmission. We have a sense that there might be some unusual methods of transmission, through intimate contact or some form of close personal contact that we’ve not previously associated with monkeypox.”
The WHO, which previously designated monkeypox as a priority pathogen, has organized a meeting of experts on monkeypox and orthopoxviruses — the wider family of pox viruses — for early next week. Among the issues the experts will likely tackle is an apparent change in the epidemiology of the disease in countries where the virus is endemic that has occurred in recent years.
“We’re seeing a shift in the age distribution of cases. We’re seeing a shift in the geographic distribution of cases,” said Michael Ryan, executive director of the WHO’s Health Emergencies Program. “We have to really understand that deep ecology. We have to really understand human behavior in those regions and we have to try to prevent the disease from reaching humans in the first place.”
The monkeypox virus is related to the variola virus, which caused smallpox, a once dreaded disease that was declared eradicated in 1980. The symptoms of monkeypox are similar to but milder than smallpox.
Infected people develop flu-like symptoms — fever, body aches, chills — but also swollen lymph nodes. With one to three days of the onset of fever, a distinctive rash appears, often starting on the face. Many conditions can cause rashes but the monkeypox rash has some unusual features, notably the fact that vesicles can form on the palms of the hands.
In countries where it is endemic, the virus is believed to mainly spread to people from infected animals when people kill or prepare bushmeat for consumption.
Once the virus jumps to people, human-to-human transmission can occur via respiratory droplets — virus-laced saliva that can infect the mucosal membranes of the eyes, nose, and throat — or by contact with monkeypox lesions or bodily fluids, with the virus entering through small cuts in the skin. It can also be transmitted by contact with clothing or linens contaminated with material from monkeypox lesions.
Cases outside of Africa have been rare, though there was a large outbreak in the United States in 2003 that involved 47 confirmed and probable cases in six states. That outbreak, the first reported from outside of Africa, was traced back to the importation of small mammals from Ghana.
However, in the past few years there has been small increases in exported monkeypox cases. The U.S. detected two in 2021, both in travelers who had returned from Nigeria. The U.K. has seen multiple importations in the past few years and Israel and Singapore have also detected cases.
McQuiston said the number of exported cases from Nigeria in particular appear to be at odds with the reported number of cases in the country itself.
“I think that we are concerned about the number of exported cases in travelers we’ve seen. And to have so many of them in the last few years is simply a flag to us that there’s a lot more monkeypox transmission happening in Nigeria than perhaps the [official] numbers would suggest,” she said.
“And I think it also is a flag to us that the more traditional routes of transmission that we think of such as hunting wild animals, contact with bushmeat, living at that interface between the jungle and small communities does not seem to be a driver of transmission in terms of what we see happening. And so that makes us cast a wider net about what risk factors might be.”
There is no licensed vaccine to protect against monkeypox, nor are there specific drugs for the disease. But it is believed that vaccines and drugs developed and stockpiled as a hedge against a return of smallpox are useful. In the 2003 outbreak in the U.S., smallpox vaccine was used.
The WHO’s Van Kerkhove noted that some of these products have been licensed using what is known as the animal rule, where animal efficacy data are used as a surrogate because the lack of circulating smallpox means the vaccines or drugs can’t be tested for efficacy in people. As a result, any such product could only be used in the context of a clinical trial, she said.
“There are options. We just have to make sure that they’re used appropriately. One of the things related to vaccines is we want to make sure if the vaccines are needed and used, they’re used among populations that need them the most. There’s not ample supply of anything right now,” she said.
Still, she expressed confidence the outbreak can be controlled.
“What we need to do right now is focus on stopping the spread. And we can do that. We can do that with the appropriate messaging, with the appropriate testing … with supportive isolation and clinical care as necessary, with protecting health workers,” Van Kerkhove said.
Helen Branswell
Senior Writer, Infectious Disease
Helen covers issues broadly related to infectious diseases, including outbreaks, preparedness, research, and vaccine development.
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak
Two more European countries reported unusual monkeypox cases on Wednesday, a development that suggests an outbreak first spotted in the United Kingdom is more widespread than first believed.
www.statnews.com
jward
passin' thru
Monkeypox and Smallpox Vaccine Guidance (CDC)
When properly administered before exposure to monkeypox vaccines are effective at protecting people against monkeypox.
ACAM200 and JYNNEOSTM (also known as Imvamune or Imvanex) are the two currently licensed vaccines in the United States to prevent smallpox. JYNNEOS is also licensed specifically to prevent monkeypox.
ACAM2000 is administered as a live virus preparation that is inoculated into the skin by pricking the skin surface. Following a successful inoculation, a lesion will develop at the site of the vaccination. The virus growing at the site of this inoculation lesion can be spread to other parts of the body or even to other people. Individuals who receive vaccination with ACAM2000 must take precautions to prevent the spread of the vaccine virus.
JYNNEOSTM is administered as a live virus that is non-replicating. It is administered as two subcutaneous injections four weeks apart. There is no visible “take” and as a result, no risk for spread to other parts of the body or other people. People who receive JYNNEOS TM are not considered vaccinated until they receieve both doses of the vaccine.
CDC, in conjunction with the Advisory Committee on Immunization Practices (ACIP), provides recommendations on who should receive smallpox vaccination in a non-emergency setting. At this time, vaccination with ACAM2000 is recommended for laboratorians working with certain orthopoxviruses and military personnel. The ACIP is currently evaluating JYNNEOSTM for the protection of people at risk of occupational exposure to orthopoxviruses in a pre-event setting.
Vaccine Effectiveness
Because monkeypox virus is closely related to the virus that causes smallpox, the smallpox vaccine can protect people from getting monkeypox. Past data from Africa suggests that the smallpox vaccine is at least 85% effective in preventing monkeypox. The effectiveness of JYNNEOSTM against monkeypox was concluded from a clinical study on the immunogenicity of JYNNEOS and efficacy data from animal studies.
Smallpox and monkeypox vaccines are effective at protecting people against monkeypox when given before exposure to monkeypox. Experts also believe that vaccination after a monkeypox exposure may help prevent the disease or make it less severe.
Receiving Vaccine After Exposure to Monkeypox Virus
Vaccination after exposure to monkeypox virus is still possible. However, the sooner an exposed person gets the vaccine, the better.
CDC recommends that the vaccine be given within 4 days from the date of exposure in order to prevent onset of the disease. If given between 4–14 days after the date of exposure, vaccination may reduce the symptoms of disease, but may not prevent the disease.
Smallpox and monkeypox vaccines are effective at protecting people against monkeypox when given before exposure to monkeypox. Experts also believe that vaccination after a monkeypox exposure may help prevent the disease or make it less severe.
Revaccination After Exposure
Persons exposed to monkeypox virus and who have not received the smallpox vaccine within the last 3 years, should consider getting vaccinated.
The sooner the person receives the vaccine, the more effective it will be in protecting against monkeypox virus.
Vaccine Risks vs. Monkeypox Disease
For most persons who have been exposed to monkeypox, the risks from monkeypox disease are greater than the risks from the smallpox or monkeypox vaccine.
Monkeypox is a serious disease. It causes fever, headache, muscle aches, backache, swollen lymph nodes, a general feeling of discomfort, exhaustion, and severe rash. Studies of monkeypox in Central Africa—where people live in remote areas and are medically underserved—showed that the disease killed 1–10% of people infected.
In contrast, most people who get the smallpox or monkeypox vaccine have only minor reactions, like mild fever, tiredness, swollen glands, and redness and itching at the place where the vaccine is given. However, these vaccines do have more serious risks, too.
Based on past experience, it is estimated that between 1 and 2 people out of every 1 million people vaccinated will die as a result of life-threatening complications from the vaccine.
Monkeypox and Smallpox Vaccine Guidance | Monkeypox | Poxvirus | CDC
When properly administered before exposure to monkeypox vaccines are effective at protecting people against monkeypox.
ACAM200 and JYNNEOSTM (also known as Imvamune or Imvanex) are the two currently licensed vaccines in the United States to prevent smallpox. JYNNEOS is also licensed specifically to prevent monkeypox.
ACAM2000 is administered as a live virus preparation that is inoculated into the skin by pricking the skin surface. Following a successful inoculation, a lesion will develop at the site of the vaccination. The virus growing at the site of this inoculation lesion can be spread to other parts of the body or even to other people. Individuals who receive vaccination with ACAM2000 must take precautions to prevent the spread of the vaccine virus.
JYNNEOSTM is administered as a live virus that is non-replicating. It is administered as two subcutaneous injections four weeks apart. There is no visible “take” and as a result, no risk for spread to other parts of the body or other people. People who receive JYNNEOS TM are not considered vaccinated until they receieve both doses of the vaccine.
CDC, in conjunction with the Advisory Committee on Immunization Practices (ACIP), provides recommendations on who should receive smallpox vaccination in a non-emergency setting. At this time, vaccination with ACAM2000 is recommended for laboratorians working with certain orthopoxviruses and military personnel. The ACIP is currently evaluating JYNNEOSTM for the protection of people at risk of occupational exposure to orthopoxviruses in a pre-event setting.
Vaccine Effectiveness
Because monkeypox virus is closely related to the virus that causes smallpox, the smallpox vaccine can protect people from getting monkeypox. Past data from Africa suggests that the smallpox vaccine is at least 85% effective in preventing monkeypox. The effectiveness of JYNNEOSTM against monkeypox was concluded from a clinical study on the immunogenicity of JYNNEOS and efficacy data from animal studies.
Smallpox and monkeypox vaccines are effective at protecting people against monkeypox when given before exposure to monkeypox. Experts also believe that vaccination after a monkeypox exposure may help prevent the disease or make it less severe.
Receiving Vaccine After Exposure to Monkeypox Virus
Vaccination after exposure to monkeypox virus is still possible. However, the sooner an exposed person gets the vaccine, the better.
CDC recommends that the vaccine be given within 4 days from the date of exposure in order to prevent onset of the disease. If given between 4–14 days after the date of exposure, vaccination may reduce the symptoms of disease, but may not prevent the disease.
Smallpox and monkeypox vaccines are effective at protecting people against monkeypox when given before exposure to monkeypox. Experts also believe that vaccination after a monkeypox exposure may help prevent the disease or make it less severe.
Revaccination After Exposure
Persons exposed to monkeypox virus and who have not received the smallpox vaccine within the last 3 years, should consider getting vaccinated.
The sooner the person receives the vaccine, the more effective it will be in protecting against monkeypox virus.
Vaccine Risks vs. Monkeypox Disease
For most persons who have been exposed to monkeypox, the risks from monkeypox disease are greater than the risks from the smallpox or monkeypox vaccine.
Monkeypox is a serious disease. It causes fever, headache, muscle aches, backache, swollen lymph nodes, a general feeling of discomfort, exhaustion, and severe rash. Studies of monkeypox in Central Africa—where people live in remote areas and are medically underserved—showed that the disease killed 1–10% of people infected.
In contrast, most people who get the smallpox or monkeypox vaccine have only minor reactions, like mild fever, tiredness, swollen glands, and redness and itching at the place where the vaccine is given. However, these vaccines do have more serious risks, too.
Based on past experience, it is estimated that between 1 and 2 people out of every 1 million people vaccinated will die as a result of life-threatening complications from the vaccine.
Monkeypox and Smallpox Vaccine Guidance | Monkeypox | Poxvirus | CDC
jward
passin' thru
Gates Germ-Game Warning Motivates Smallpox Vaccine Discussions
Fact checked by Robert Carlson, MD
Published
November 8, 2021
Fact checked
November 9, 2021
JYNNEOS is an FDA-approved non-replicating smallpox and monkeypox vaccine
(Precision Vaccinations)
Policy Exchange recently hosted Mr. Bill Gates, Co-Chair of the Bill and Melinda Gates Foundation, and Rt Hon Jeremy Hunt MP, Chair of the Health Select Committee, who discussed the potential of future pandemics.
In a wide-ranging discussion on November 4, 2021, Gates called for a new international Pandemic Task Force, with a budget of about $1 billion per year.
According to Microsoft's founder, governments must invest billions in research and development to prepare for future pandemics and smallpox terror strikes.
This new effort would "germ game" potential pandemics and bioterrorist attacks such as smallpox attacks on airports. The Science Times reported germ games are ‘when government agencies practice scenarios of another pandemic catastrophe.’
“You say, OK, what if a bioterrorist brought smallpox to 10 airports? You know, how would the world respond to that?
“There are naturally-caused epidemics and bioterrorism-caused epidemics that could even be way worse than what we experienced today.”
“And citizens expect their governments not to let that happen again,” Gates commented.
Gates has previously issued similar warnings.
In an April 2015 TED presentation, "The next outbreak? We're not ready," Gates warned of the hazards of a highly contagious virus and a major pandemic, stressing the importance of being prepared.
Based on recent Centers for Disease Control and Prevention (CDC) vaccine advisory committee meetings, the U.S. is focused on the threat of smallpox.
On November 3, 2021, following an introduction by Pablo Sanchez, M.D. Chair of the Orthopoxvirus workgroup, the CDC’s Advisory Committee on Immunization Practices reviewed the two presentations focused on the smallpox vaccine JYNNEOS.
Produced by Bavarian Nordic, JYNNEOS was initially approved in 2019 by the U.S. Food and Drug Administration (FDA) and is indicated for preventing smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection.
JYNNEOS is the only FDA-approved non-replicating smallpox vaccine and the only FDA-approved monkeypox vaccine for non-military use.
Brett Petersen, M.D., MPH, presented the new proposed ‘clinical guidance for the use of JYNNEOS as it compares to an older smallpox vaccine, ACAM2000, which the ACIP currently recommends.
Many persons with contraindications to vaccination with ACAM2000 (e.g., atopic dermatitis, immunocompromising conditions, breastfeeding, or pregnancy) may receive vaccination with JYNNEOS.
A person can be considered fully immunized two weeks following administration of the second dose of JYNNEOS when clinical studies have demonstrated maximal antibody titers.
As a replication-deficient vaccine, JYNNEOS does not produce a vaccine site lesion that can be used as a marker of successful vaccination.
And routine titer testing is not recommended following vaccination with JYNNEOS to confirm successful administration of the vaccine, given that high seroconversion rates were demonstrated in clinical trials.
However, titer testing could be considered on a case-by-case basis after consultation with public health authorities for select persons with immunocompromising conditions or those working with more virulent orthopoxviruses (variola and monkeypox) to confirm an immune response has been achieved.
Currently, the smallpox vaccine is not recommended for the general public in the USA since smallpox has been eradicated. Routine smallpox vaccination among Americans stopped in 1972.
However, U.S. health officials are prepared to use a vaccine if there were a smallpox outbreak, says the CDC.
Note: Bill Gates publishes various posts at GatesNote.com.
www.precisionvaccinations.com
Fact checked by Robert Carlson, MD
Published
November 8, 2021
Fact checked
November 9, 2021
JYNNEOS is an FDA-approved non-replicating smallpox and monkeypox vaccine
(Precision Vaccinations)
Policy Exchange recently hosted Mr. Bill Gates, Co-Chair of the Bill and Melinda Gates Foundation, and Rt Hon Jeremy Hunt MP, Chair of the Health Select Committee, who discussed the potential of future pandemics.
In a wide-ranging discussion on November 4, 2021, Gates called for a new international Pandemic Task Force, with a budget of about $1 billion per year.
According to Microsoft's founder, governments must invest billions in research and development to prepare for future pandemics and smallpox terror strikes.
This new effort would "germ game" potential pandemics and bioterrorist attacks such as smallpox attacks on airports. The Science Times reported germ games are ‘when government agencies practice scenarios of another pandemic catastrophe.’
“You say, OK, what if a bioterrorist brought smallpox to 10 airports? You know, how would the world respond to that?
“There are naturally-caused epidemics and bioterrorism-caused epidemics that could even be way worse than what we experienced today.”
“And citizens expect their governments not to let that happen again,” Gates commented.
Gates has previously issued similar warnings.
In an April 2015 TED presentation, "The next outbreak? We're not ready," Gates warned of the hazards of a highly contagious virus and a major pandemic, stressing the importance of being prepared.
Based on recent Centers for Disease Control and Prevention (CDC) vaccine advisory committee meetings, the U.S. is focused on the threat of smallpox.
On November 3, 2021, following an introduction by Pablo Sanchez, M.D. Chair of the Orthopoxvirus workgroup, the CDC’s Advisory Committee on Immunization Practices reviewed the two presentations focused on the smallpox vaccine JYNNEOS.
Produced by Bavarian Nordic, JYNNEOS was initially approved in 2019 by the U.S. Food and Drug Administration (FDA) and is indicated for preventing smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection.
JYNNEOS is the only FDA-approved non-replicating smallpox vaccine and the only FDA-approved monkeypox vaccine for non-military use.
Brett Petersen, M.D., MPH, presented the new proposed ‘clinical guidance for the use of JYNNEOS as it compares to an older smallpox vaccine, ACAM2000, which the ACIP currently recommends.
Many persons with contraindications to vaccination with ACAM2000 (e.g., atopic dermatitis, immunocompromising conditions, breastfeeding, or pregnancy) may receive vaccination with JYNNEOS.
A person can be considered fully immunized two weeks following administration of the second dose of JYNNEOS when clinical studies have demonstrated maximal antibody titers.
As a replication-deficient vaccine, JYNNEOS does not produce a vaccine site lesion that can be used as a marker of successful vaccination.
And routine titer testing is not recommended following vaccination with JYNNEOS to confirm successful administration of the vaccine, given that high seroconversion rates were demonstrated in clinical trials.
However, titer testing could be considered on a case-by-case basis after consultation with public health authorities for select persons with immunocompromising conditions or those working with more virulent orthopoxviruses (variola and monkeypox) to confirm an immune response has been achieved.
Currently, the smallpox vaccine is not recommended for the general public in the USA since smallpox has been eradicated. Routine smallpox vaccination among Americans stopped in 1972.
However, U.S. health officials are prepared to use a vaccine if there were a smallpox outbreak, says the CDC.
Note: Bill Gates publishes various posts at GatesNote.com.
Gates Germ-Game Warning Motivates Smallpox Vaccine Discussions
JYNNEOS is an FDA-approved non-replicating smallpox and monkeypox vaccine
yellowlabz
Veteran Member
As if Bill Gates isn't creepy enough, those moving eyes might cause me to have a nightmare!!
helen
Panic Sex Lady
Run time over an hour.
Watch "Smallpox 2002: Silent Weapon" on YouTube
ohiohippie
Veteran Member
Exactly!