I didn’t
I use the paste
Much easier to acquire
But from what I understand you can order tablets if you prefer from ivermectin.com
CORONA Main Coronavirus thread
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I use the paste
Much easier to acquire
But from what I understand you can order tablets if you prefer from ivermectin.com
Zoner
Veteran Member
Zoner
Veteran Member
Oh OK thank you. I have the paste and I also have Noromectin the liquid which is what I used when I got omicron.
It’s the same medicine just in a different carrier for the intended species. Antibiotics are much the same but if you notice the tablet and capsule antibiotics still come in the same dosage size as the human script kind.
I have friend who is a retired doctor. He was a part of the Doctors Without Borders and traveled over seas a good bit. He was/is also a prepper. in some countries you can only get animal grade meds. He used them. We, a small group that trained for wilderness medicine, used to get together every couple months and share knowledge and learn skills.
I am not telling anyone to use the animal grade. I am not a Dr and will not give medical advice. I myself will not hesitate to use what I know.
Zoner
Veteran Member
Here is the Dr. Geert interview today.
View: https://twitter.com/philamillan/status/1543278334619947009?s=20&t=XQ3733ma99iI24oFn80Yvg
View: https://twitter.com/philamillan/status/1543278334619947009?s=20&t=XQ3733ma99iI24oFn80Yvg
psychgirl
Has No Life - Lives on TB
Go to one of the online doctors!
They’re listed all over TB if you search!
Thais how we get ours.
Zoner
Veteran Member
The interview was the usual Geert. Lots of scientific verbiage that helped me take a nap. I woke up and he was still talking science. My takeaway is that Geert is more sure about his position than ever. Just a matter of time... He did not talk about the new variant spawned in India.
psychgirl
Has No Life - Lives on TB
Thanks for the report
I still need to watch it lol
Heliobas Disciple
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ha, me too. Then I got back to it. I still half way to go. Thanks for trying to get the India question asked. Maybe he needed more time to research it. ???
HD
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*Peer Reviewed* Study Finds YOUNG Moderna Jab Recipients Have a Jaw-Dropping 44X HIGHER Risk of Developing Myocarditis Than the Unvaccinated | The Gateway Pundit | by Julian Conradson
A peer-reviewed study from researchers in France has concluded that both the experimental Pfizer and Moderna vaccines significantly increase the risk of myocarditis compared to the unvaccinated.
www.thegatewaypundit.com
*Peer Reviewed* Study Finds YOUNG Moderna Jab Recipients Have a Jaw-Dropping 44X HIGHER Risk of Developing Myocarditis Than the Unvaccinated
By Julian Conradson
Published July 2, 2022 at 9:15pm
A peer-reviewed study from researchers in France has concluded that both the experimental Pfizer and Moderna vaccines significantly increase the risk of myocarditis compared to the unvaccinated.
While both mRNA therapies were found to be linked to the life-threatening heart condition, the Moderna jabs results were particularly shocking, especially among young adults, as researchers found the risk for myocarditis diagnosis following the Moderna jab was 44 times higher risk for individuals aged 18 to 24 years old.
As for Pfizer’s jab – which fared better, but not by much – the same age group experienced a 13x elevated risk for the serious condition, according to the study that was published last week in the scientific journal, “Nature.”
The new data mirrors several other recent studies that show a link between the treatments and numerous severe medical complications in addition to myocarditis, including, but not limited to, pulmonary embolism, blood clots, and even “sudden” death.
From the study:
The largest associations are observed for myocarditis following mRNA-1273 vaccination in persons aged 18 to 24 years [Moderna 44x increase, Pfizer 13x increase]. Estimates of excess cases attributable to vaccination also reveal a substantial burden of both myocarditis and pericarditis across other age groups and in both males and females.
The risk of myocarditis was substantially increased within the first week post vaccination in both males and females (Fig. 1 and Table S2). Odds-ratios associated with the second dose of the mRNA-1273 vaccine were consistently the highest, with values up to 44 (95% CI, 22–88) and 41 (95% CI, 12–140), respectively in males and females aged 18 to 24 years but remaining high in older age groups.
While young people experienced the worst reaction to the mRNA vaccines, researchers demonstrated, as has been done across multiple studies, that the risk was elevated across all age groups and it is highest around 1-week post-vaccination.
Overall, the Pfizer and Moderna jabs were associated with an 8x and a 30x increase in myocarditis risk, respectively, when compared to the unvaccinated, according to the study.
Individuals were also found to be at a greater risk of developing pericarditis, a similar and less severe, but still serious, heart condition. However, the increase was not nearly as high, at 2.9x for Pfizer and 5.5x for Moderna.
Conversely, the risk of myocarditis was also found to be elevated by 9x in those who have been infected with the Covid-19 virus. It is unclear whether or not vaccination status was factored in for this cohort.
From the study:
We perform matched case-control studies and find increased risks of myocarditis and pericarditis during the first week following vaccination, and particularly after the second dose, with adjusted odds ratios of myocarditis of 8.1 (95% confidence interval [CI], 6.7 to 9.9) for the BNT162b2 [Pfizer] and 30 (95% CI, 21 to 43) for the mRNA-1273 [Moderna] vaccine.
The association was stronger for the mRNA-1273 vaccine with odds-ratios of 3.0 (95% CI, 1.4–6.2) for the first dose and 30 (95% CI, 21–43) for the second. The risk of pericarditis was increased in the seven days following the second dose of both vaccines, with odds ratios of 2.9 (95% CI, 2.3–3.8) for the BNT162b2 vaccine and 5.5 (95% CI, 3.3–9.0) for the mRNA-1273 vaccine.
In other words, that ‘cure’ for the virus that’s nominally worse than the seasonal flu (99.95 recovery rate overall, 99.995% among children and young people) is more likely to put recipients into the hospital with a crippling heart condition than keeping them from being hospitalized with Covid.
And, not just a little more likely, either. Another recently published study found that for every one person the Pfizer vaccine keeps out of the hospital, five (!) people will suffer a “severe adverse reaction” – aka. a serious vaccine injury.
It’s worth pointing out that the 5 to 1 ratio is only related to the Pfizer jab and it’s 13x increase in myocarditis risk. At 44x, Moderna’s ratio of severe adverse events would likely be even greater.
Unbelievably, the risk increase for the severe heart condition might even be higher than the data that the new French study shows, as researchers were limited to pulling information strictly from hospital discharge records. These records likely underscored the true number of myocarditis cases because they do not include those whose symptoms were not severe enough to be hospitalized or those who might have died suddenly before checking into a healthcare facility.
What’s more – the study only looked at those with one- and two-dose vaccinations and did not analyze the effect the booster jab had on the risk of myocarditis because it is not yet recommended for young adults in the country. This could also indicate that the true risk increase is higher, as other data has shown that with more mRNA doses, the higher the chance of developing complications.
One of the study’s authors, Dr. Sanjay Verma, even warned as much, stating that the excluded data “may yield even higher risk than reported.”
From Dr. Verma, who spoke with The Epoch Times about the French study:
“There have been reports (pdf) of autopsy-proven myocarditis after vaccination and anecdotal evidence of patients being dismissed by ER and never being hospitalized. Adjusting for these excluded subsets may yield even higher risk than reported in this study. Follow-up of the patients in this study was limited to one month after discharge. However, a previous cardiac MRI study found about 75 percent of patients with vaccine-associated myocarditis can have persistent MRI abnormalities 3–8 months after initial diagnosis.”
Dr. Verma also slammed the US Centers for Disease Control and Prevention (CDC) for misleading the public about the true incidence rate of myocarditis and its relation to the experimental vaccine. According to the expert cardiologist, the CDC has been “erroneously suggest[ing]” that the risk of myocarditis after Covid infection is higher than it is following mRNA injection – something his data, and others, have thoroughly disproven.
Nevertheless, the CDC and the public health ‘experts’ refuse to divert from the course.
Dr. Verma continued:
“Both SARS-CoV2 infection and COVID mRNA vaccines have been associated with myocarditis. Knowing the spike protein’s affinity to ACE2 receptors in the heart and spike protein’s injury to cardiomyocytes (cells of the heart), the association of myocarditis with SARS-CoV2 virus or spike protein-based mRNA vaccination was not entirely unexpected.
For the cases of myocarditis after SARS-CoV2, CDC uses officially confirmed PCR+ ‘cases,’ even though their own seroprevalence data demonstrates that far more people have been infected than officially conformed PCR+ ‘cases.’ For example, seroprevalence data as of Feb 21, 2022, reveals 75 percent (about 54 million) of all children have been infected compared to 12 million officially confirmed PCR+ ‘cases’ (i.e., the actual number of kids infected is 4.5 times greater than PCR+ ‘cases’). Therefore, calculating the risk of myocarditis after SARS-CoV2 infection, the rate noted by CDC would therefore need to be reduced by 4.5 times. Thus far, CDC has not adjusted its COVID-19 morbidity and mortality data accordingly.”
To download the new *peer-reviewed* French study, it can be found here.
Heliobas Disciple
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Covid-19 may have originated in US biolab – Lancet commission chair
Jeffrey Sachs, who chairs Covid-19 commission at the prestigious medical journal, has claimed the deadly virus did not come out of nature
www.unz.com
Covid-19 May Have Originated in US Biolab – Lancet Commission Chair
Jeffrey Sachs, who chairs Covid-19 commission at the prestigious medical journal, has claimed the deadly virus did not come out of nature
RT Staff • July 1, 2022
Covid-19 did not come out of some natural reservoir but rather “out of US lab biotechnology” in an accident, world-renowned economist and author Jeffrey Sachs has claimed, speaking at a conference hosted by the GATE Center think tank in Spain in mid-June.
While introducing this “provocative statement,” Sachs suggested that he was in the loop, as he chairs the Covid-19 commission at prestigious medical journal The Lancet.
“So it’s a blunder, in my view, of biotech, not an accident of a natural spillover,” he reiterated.
2 hr 21 min 11 sec
The academic noted that while “we don’t know for sure” if this is the case, there is “enough evidence” pointing to this, which “should be looked into.” Sachs lamented that this version is, however, “not being investigated, not in the United States, not anywhere.”
Back in May, Sachs, along with Columbia University professor of molecular pharmacology and therapeutics Neil Harrison, penned an article in the Proceedings of the National Academy of Sciences, suggesting Covid-19 had originated in a laboratory. In the paper, the two academics called for greater transparency on the part of US federal agencies and universities, arguing that a lot of pertinent evidence was not disclosed.
Virus databases, biological samples, viral sequences, email communications, and laboratory notebooks could all help shed light on the pandemic origin, according to Sachs and Harrison. However, none of these materials had been subjected to “independent, transparent, and scientific scrutiny,” they argued.
As an indicator that Covid 19 had originated from a laboratory, the authors brought up the fact that a sequence of eight amino acids on a critical part of the virus’s spike protein is similar to an amino acid sequence found in cells that line human airways.
In fact, Sachs is not the first one to suggest that the deadly virus had not occurred naturally.
While there is no conclusive evidence that would trace Covid-19’s origin beyond a reasonable doubt, the World Health Organization (WHO) concluded in February 2021 that it had most likely been transmitted from an animal, possibly a bat, to humans.
The highly contagious virus was first identified in Wuhan, China, in late 2019. It then quickly spread globally, with several waves claiming millions of lives by May 2022, according to the WHO.
(Republished from RT by permission of author or representative)
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Ivy League study on boosters, COVID 'rebounds' fuel skepticism of federal narratives
NBA COVID testing shows boosted individuals take longer than non-boosted to clear Omicron BA.1 infections. Fauci appears to contradict FDA guidance with second round of Paxlovid. Florida surgeon general accuses top House Democrat of misinformation.
justthenews.com
Ivy League study on boosters, COVID 'rebounds' fuel skepticism of federal narratives
NBA COVID testing shows boosted individuals take longer than non-boosted to clear Omicron BA.1 infections. Fauci appears to contradict FDA guidance with second round of Paxlovid. Florida surgeon general accuses top House Democrat of misinformation.
By Greg Piper
Updated: June 30, 2022 - 11:29pm
As the nation's most powerful and twice-boosted infectious disease doctor battles a COVID-19 "rebound" two weeks after testing positive, new research from the public health schools at Harvard and Yale suggests the boosted fared worse against the first Omicron subvariant than the non-boosted.
The FDA is so alarmed by the "waning effectiveness" of boosters, whose formulation is still based on the ancestral Wuhan strain, that it asked manufacturers Thursday to add a "spike protein component" from the fourth and fifth Omicron subvariants to this fall's boosters.
Along with candid testimony by then-President Trump's coronavirus response coordinator, the developments raise questions about the basis for COVID vaccine mandates, particularly requiring low-risk populations to stay "up to date" with boosters, as some colleges demand of students.
They also lend support for Florida's cautious approach, under fire by the Democrat-led U.S. House coronavirus subcommittee.
The June 22 preprint, which has not been peer-reviewed, analyzed about 3,000 infections determined by longitudinal PCR tests with cycle thresholds under 30. Thresholds of 35 and higher have been widely used throughout the pandemic despite acknowledgments from top federal health officials that they tend to catch dead or noninfectious viral loads.
The tests came from the NBA's "occupational health cohort" from July 2020, when the league's so-called "bubble" started, through January this year. About half were Omicron BA.1 infections.
"Vaccination and infection history information were available for most individuals, allowing us to stratify the viral trajectories and probability of Ct<30 by exposure history and lineage," coauthor James Hay, postdoctoral researcher in Harvard's Center for Communicable Disease Dynamics, wrote in a tweet thread summarizing the results.
Researchers found the same pattern after excluding the players, the youngest members of the "relatively young cohort" and a minority of tested individuals.
"Viral rebounds rare but more frequent BA.1/booster era," Hay said. Boosted individuals with BA.1 infections "had longer [viral] clearance times than non-boosted" and lower "spike antibody titers" from the Wuhan strain before boosting, though Hay noted the researchers' prior NBA study showed the boosted were less likely to get BA.1 infections.
He questioned whether "original antigenic sin" from repeated doses of the same formulations against evolving variants could explain why the boosted took longer to clear infections.
A better explanation is the NBA cohort they studied has a "survival bias," Hay said. Looking at past antibody titers to the Wuhan strain, the researchers found many individuals with titers in the fall, between their second dose and the booster.
They concluded individuals with "low pre-booster" titers are "poor responders." Hay said this was affirmed by their finding that boosted BA.1 infectees had lower average pre-booster titers than non-boosted BA.1 infectees.
National Institute of Allergy and Infectious Diseases Director Anthony Fauci told the Foreign Policy Global Health Forum this week that he tested negative for three days after clearing his mid-June COVID infection, but the positives came back on the fourth day.
Fauci said he then "started to feel really poorly, much worse than in the first go-around," according to Spectrum News. He had been taking Pfizer's antiviral Paxlovid, which the CDC says has been associated with rebounds.
"So I went back on Paxlovid, and right now I am on my fourth day of a five-day course" and "certainly don't feel acutely ill," Fauci said, apparently ignoring FDA guidance.
After Pfizer CEO Albert Bourla recommended another course of Paxlovid to treat rebounds in May, FDA Office of Infectious Diseases Director John Farley said the agency had "no evidence of benefit" from a second course in patients with recurrent symptoms, Fierce Pharma reported. NIAID didn't answer Just the News queries about Fauci undermining the FDA.
Former coronavirus coordinator Deborah Birx also helped feed mistrust in federal pronouncements and directives in a viral exchange with Rep. Jim Jordan (R-Ohio) last week.
President Biden and CDC Director Rochelle Walensky repeatedly said vaccinated people couldn't get reinfected last year, even as breakthrough infections became common, prompting Jordan to ask if federal officials were "guessing ... or lying."
Birx responded, "I don't know," while conceding that natural immunity was at least as protective as vaccine immunity.
Fauci's own agency contributed to global research suggesting natural immunity is broader and longer-lasting.
Apparently referring to mask-wearing and social distancing, Birx said her own vaccinated family "used layered
protection during surges" because "every four months reinfection was reoccurring in South Africa," where Omicron was discovered.
Federal claims that the vaccinated couldn't transmit COVID were based on "hope," she said. Jordan answered: "So they were either guessing, lying or hoping."
As comments by Birx and Fauci fueled further skepticism of federal claims, Rep. Jim Clyburn (D-S.C.) accused Florida of working to "impede access to lifesaving coronavirus vaccines" to young children by not preordering products that have newly received emergency use authorization (EUA) from the FDA.
While the chairman of the House Select Subcommittee on the Coronavirus Crisis said Republican Gov. Ron DeSantis promoted "anti-vaccine misinformation," Clyburn implied COVID vaccines would reduce "the risk of severe illness, hospitalization, and death" for young children, which was not studied in the Pfizer and Moderna trials for ages as young as 6 months.
Florida Surgeon General Joseph Ladapo fired back at Clyburn for his "blatantly false statements" in a press release Wednesday, saying they illustrate "why people trust Florida — and not the federal government."
The state didn't preorder pediatric vaccines because it's an "unnecessary relic" of a time when "supply was low and demand was high among high-risk populations," Ladapo wrote to Clyburn, noting the lack of evidence for the Democrat's claims about COVID vaccines and children.
Ladapo said his department observed "inefficiencies" in previous vaccine authorization preorders but has "never restricted" private providers from ordering, as did some pediatricians the day the EUA was approved. States that preordered "will likely be left holding" a surplus "due to the lack of demand."
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For now, wary US treads water with transformed COVID-19
The fast-changing coronavirus has kicked off summer in the U.S. with lots of infections but relatively few deaths compared to its prior incarnations. “It’s going to be a good summer and we deserve this break,” said Ali Mokdad, a professor of health metrics sciences at the University of...
For now, wary US treads water with transformed COVID-19
CARLA K. JOHNSON
Sat, July 2, 2022, 8:49 AM
The fast-changing coronavirus has kicked off summer in the U.S. with lots of infections but relatively few deaths compared to its prior incarnations.COVID-19 is still killing hundreds of Americans each day, but is not nearly as dangerous as it was last fall and winter.
“It’s going to be a good summer and we deserve this break,” said Ali Mokdad, a professor of health metrics sciences at the University of Washington in Seattle.
With more Americans shielded from severe illness through vaccination and infection, COVID-19 has transformed — for now at least — into an unpleasant, inconvenient nuisance for many.
“It feels cautiously good right now,” said Dr. Dan Kaul, an infectious diseases specialist at the University of Michigan Medical Center in Ann Arbor. “For the first time that I can remember, pretty much since it started, we don’t have any (COVID-19) patients in the ICU.”
As the nation marks July Fourth, the average number of daily deaths from COVID-19 in the United States is hovering around 360. Last year, during a similar summer lull, it was around 228 in early July. That remains the lowest threshold in U.S. daily deaths since March 2020, when the virus first began its U.S. spread.
But there were far fewer reported cases at this time last year — fewer than 20,000 a day. Now, it’s about 109,000 — and likely an undercount as home tests aren’t routinely reported.
Today, in the third year of the pandemic, it’s easy to feel confused by the mixed picture: Repeat infections are increasingly likely, and a sizeable share of those infected will face the lingering symptoms of long COVID-19.
Yet, the stark danger of death has diminished for many people.
“And that’s because we’re now at a point that everyone’s immune system has seen either the virus or the vaccine two or three times by now,” said Dr. David Dowdy, an infectious disease epidemiologist at Johns Hopkins Bloomberg School of Public Health. “Over time, the body learns not to overreact when it sees this virus.”
“What we’re seeing is that people are getting less and less ill on average,” Dowdy said.
As many as 8 out of 10 people in the U.S. have been infected at least once, according to one influential model.
The death rate for COVID-19 has been a moving target, but recently has fallen to within the range of an average flu season, according to data analyzed by Arizona State University health industry researcher Mara Aspinall.
At first, some people said coronavirus was no more deadly than the flu, "and for a long period of time, that wasn’t true,” Aspinall said. Back then, people had no immunity. Treatments were experimental. Vaccines didn’t exist.
Now, Aspinall said, the built-up immunity has driven down the death rate to solidly in the range of a typical flu season. Over the past decade, the death rate for flu was about 5% to 13% of those hospitalized.
Big differences separate flu from COVID-19: The behavior of the coronavirus continues to surprise health experts and it’s still unclear whether it will settle into a flu-like seasonal pattern.
Last summer — when vaccinations first became widely available in the U.S. — was followed by the delta surge and then the arrival of omicron, which killed 2,600 Americans a day at its peak last February.
Experts agree a new variant might arise capable of escaping the population’s built-up immunity. And the fast-spreading omicron subtypes BA.4 and BA.5 might also contribute to a change in the death numbers.
“We thought we understood it until these new subvariants emerged,” said Dr. Peter Hotez, an infectious disease specialist at the Baylor College of Medicine in Texas.
It would be wise, he said, to assume that a new variant will come along and hit the nation later this summer.
“And then another late fall-winter wave,” Hotez said.
In the next weeks, deaths could edge up in many states, but the U.S. as a whole is likely to see deaths decline slightly, said Nicholas Reich, who aggregates coronavirus projections for the COVID-19 Forecast Hub in collaboration with the Centers for Disease Control and Prevention.
“We’ve seen COVID hospitalizations increase to around 5,000 new admissions each day from just over 1,000 in early April. But deaths due to COVID have only increased slightly over the same time period,” said Reich, a professor of biostatistics at University of Massachusetts Amherst.
Unvaccinated people have a six times higher risk of dying from COVID-19 compared with people with at least a primary series of shots, the CDC estimated based on available data from April.
This summer, consider your own vulnerability and that of those around you, especially in large gatherings since the virus is spreading so rapidly, Dowdy said.
“There are still people who are very much at risk,” he said.
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Vaccine in Children Only 48 Percent Effective Weeks After Second Dose
www.theepochtimes.com
Vaccine in Children Only 48 Percent Effective Weeks After Second Dose
By Enrico Trigoso
July 2, 2022
An Israeli study assessed the effectiveness of BNT162b2 COVID-19 vaccination (Pfizer) against the Omicron variant in children 5 to 11 years old using a large health care database and found the vaccine effectiveness (VE) to be 48 percent 7–21 days after dose 2 for symptomatic infection.
People with evidence of prior COVID infection by PCR, antigen, or serology test were excluded.
A U.S. study of a lesser scale found that VE in children declined from 60 percent to 28.9 percent from month 1 to month 2 after the second dose of Pfizer.
Cardiologist Sanjay Verma concluded that “therefore, if this Israeli study were to follow the children beyond 21 days, it is probable the VE would be lower than 48 percent.”
The authors of the study noted that assessment of “vaccine effectiveness against more severe outcomes such as hospitalization were not possible, because they were very rare in the study population.”
“In the US, American Academy of Pediatric data note a hospitalization rate of 0.7 percent in children based upon officially confirmed PCR+ infections. This study and this study previously found that 40 percent of pediatric COVID+ hospitalizations may have been over estimated when differentiating those hospitalized for COVID pneumonia versus those who were hospitalized for other causes but had incidental COVID+ testing during routine surveillance,” Verma noted.
“Therefore, the true hospitalization rate may actually be 0.42 percent of children infected with SARS-CoV2. CDC seroprevalence data report 75 percent of all children have already been infected (4.5 times more than officially confirmed PCR+ results). Perhaps the true SARS-Cov2 hospitalization rate for children then is as low as 0.09 percent. With such low incidence of COVID+ hospitalizations in pediatric population, most trials are not large enough to detect a statistically significant difference in COVID+ hospitalizations (or deaths) between vaccinated and unvaccinated children,” he concluded.
The study notes that 17 percent of the children were obese or overweight, while for the U.S. study, 35 percent of the children were so.
For the Israeli study, 43 percent of the population had received at least three doses of influenza vaccine in the past five years, while in the United States, an estimated 58 percent of children receive an annual flu vaccine, and some schools require the influenza vaccine.
The Israeli study also notes that “many of the children in our study cohort did not receive a second dose within the study follow-up period.”
“mRNA COVID-19 vaccinations do have a known risk of myocarditis and other rare severe adverse reactions. To better contextualize the risk-benefit analysis it would be helpful to know why the children did not receive the second dose,” Verma added.
“Statistics show the rate of COVID-19 associated hospitalization among children aged 5 to 11 is 0.0008 percent,” writes Dr. Joseph Mercola. “In real-world terms, that’s so close to zero you basically cannot lower it any further. Yet, despite such reassuring data, children in this age group are urged to get two to three doses of the COVID jab, even though side effects of the injection could harm them for life, or kill them.”
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Most hospital admission with, not for
14 min 30 sec
Jul 2, 2022
Dr. John Campbell
Majority of covid admissions are now incidental, US, Variant Proportions https://covid.cdc.gov/covid-data-trac... BA.2 5.7% BA.2.12.1 42% BA.5 36.6% BA.4 15.7% BA.1s 0% Delta 0% Others 0% Resultant hospitalizations Up 12% on the week Deaths, 387, 7 day average, up 23% Since January 2020, 1 in 327 people have died https://covid.cdc.gov/covid-data-trac... ONS https://www.ons.gov.uk/peoplepopulati... Prediction based on Zoe data https://health-study.joinzoe.com/data England, more people have been infected already Hospitalised in the UK https://coronavirus.data.gov.uk/detai... About a third admitted for covid Two thirds with covid Long covid Weakness / tiredness Shortness of breath Muscle ache Trouble sleeping Difficulty concentrating Headache Anxiety / worry Low mood Loss of smell Memory loss / confusion Loss of taste Cough Vertigo / dizziness Chest pain Palpitations Loss of appetite Sore throat Nausea / vomiting Abdominal pain Diarrhoea Fever Among the most deprived Unable to work from home, 80.6% Risk of developing long COVID symptoms, 11.1% Among the least deprived Unable to work from home, 62.6% Risk of developing long COVID symptoms, 8.1%
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Air Pollution Linked With More Severe COVID-19
A new study finds an association between air pollution and worse outcomes after COVID-19 infection According to a recent study published in the Canadian Medical Association Journal, several common air pollutants, such as ground-level ozone, are related to more severe outcomes following SARS-CoV-2 i
scitechdaily.com
Air Pollution Linked With More Severe COVID-19
By Canadian Medical Association Journal
July 2, 2022
A new study finds an association between air pollution and worse outcomes after COVID-19 infection
According to a recent study published in the Canadian Medical Association Journal, several common air pollutants, such as ground-level ozone, are related to more severe outcomes following SARS-CoV-2 infection, including admission to the intensive care unit (ICU).
To see whether there was a connection between long-term air pollution exposure and COVID-19 severity, researchers evaluated data on all 151,105 patients aged 20 and over with confirmed SARS-CoV-2 infection in 2020 in Ontario, Canada who were not in a long-term care facility. They created a simulation of historical exposure to three prevalent air pollutants before the pandemic: fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ground-level ozone (O3). The authors controlled for characteristics such as date of diagnosis, gender and age, being part of an outbreak, essential worker status, neighborhood socioeconomic status, health care access (including past influenza vaccine history, previous outpatient visits), and other factors.
“We observed that people with SARS-CoV-2 infection who lived in areas of Ontario with higher levels of common air pollutants (PM2.5, NO2, and O3) were at elevated risk of being admitted to the ICU after we adjusted for individual and contextual confounding factors, even when the air pollution level was relatively low,” writes Dr. Hong Chen, Health Canada and ICES, with coauthors.
They also found an elevated risk of hospitalization with chronic exposure to PM2.5 and O3, and an increased risk of death from COVID-19 with chronic exposure to O3.
These results add to the growing reports linking air pollution to COVID-19 severity from other countries, including Spain and Mexico.
“Given the ongoing pandemic, our findings that underscore the link between chronic exposure to air pollution and more severe COVID-19 could have important implications for public health and health systems,” write the authors.
As to the mechanisms of how long-term exposure to air pollution may be influencing the severity of COVID-19, the researchers call for more research.
The study was funded by Health Canada.
Reference: “Association between long-term exposure to ambient air pollution and COVID-19 severity: a prospective cohort study” by Chen Chen, John Wang, Jeff Kwong, JinHee Kim, Aaron van Donkelaar, Randall V. Martin, Perry Hystad, Yushan Su, Eric Lavigne, Megan Kirby-McGregor, Jay S. Kaufman, Tarik Benmarhnia and Hong Chen, 24 May 2022, Canadian Medical Association Journal.
DOI: 10.1503/cmaj.220068
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What Is the Origin of COVID-19 Variants Like Omicron?
A new study explains where COVID-19 variants come from New research shows that people with weakened immune systems are more likely to get chronic infections and produce virus variants that bear multiple antibody-resistant mutations. However, there is good news. While many distinct variations develo
scitechdaily.com
What Is the Origin of COVID-19 Variants Like Omicron?
By Tel-Aviv University
July 2, 2022
A new study explains where COVID-19 variants come from
New research shows that people with weakened immune systems are more likely to get chronic infections and produce virus variants that bear multiple antibody-resistant mutations. However, there is good news. While many distinct variations develop in immunocompromised individuals, their likelihood of spreading is small.
According to recent research from Tel Aviv University, immunosuppressed chronic COVID-19 patients are thought to be the source of several SARS-CoV-2 variants. The researchers hypothesize that a compromised immune reaction, particularly in the lower airways of these chronic patients, may delay complete recovery from the virus and cause the virus to evolve often during the course of prolonged infection. In other words, the researchers explain that the virus’s unrestricted survival and reproduction in the body of the immunosuppressed patient result in the emergence of numerous variants.
Furthermore, the variations reported in chronically sick COVID-19 patients had many of the same mutations in their development as those found in variants of concern for severe illness, notably those linked with evading disease-killing antibodies. The new findings show that, although rapidly-spreading variations are rare among the numerous strains harbored by immunocompromised people, the likelihood increases and they do arise when global infection rates boom.
The study was led by Prof. Adi Stern and Ph.D. student Sheri Harari of the Shmunis School of Biomedicine and Cancer Research at the Wise Faculty of Life Sciences at Tel Aviv University, in collaboration with Dr. Yael Paran and Dr. Suzy Meijer of Tel Aviv Sourasky Medical Center (Ichilov). It was published in the prestigious journal Nature Medicine on June 20th, 2022.
Prof. Stern explains that since the outbreak of COVID-19, the rate at which the virus evolves has been somewhat puzzling. During the first year of the pandemic, a relatively slow but constant rate of mutations was observed. However, since the end of 2020, the world has witnessed the emergence of variants that are characterized by a large number of mutations, far exceeding the rate observed during the first year.
Various scientific hypotheses about the link between chronic COVID-19 patients and the rate of the accumulation of mutations have surfaced, but nothing definitive has been proven yet. In this new study, Prof. Stern and the team shed light on some pieces of this complex puzzle and try to answer the question of how variants are formed.
Prof. Stern explains: “The coronavirus is characterized by the fact that in every population, there are people who become chronically infected. In the case of these patients, the virus remains in their body for a lengthy period of time, and they are at high risk for recurrent infection. In all of the cases observed so far, these were immunocompromised patients – part of their immune system is damaged and unable to function. In biological evolutionary terms, these patients constitute an ‘incubator’ for viruses and mutations – the virus persists in their body for a long time and succeeds in adapting to the immune system, by accumulating various mutations.”
The study involved an examination of chronic COVID-19 patients at the Tel Aviv Sourasky Medical Center (“Ichilov Hospital”). According to Prof. Stern, the results reveal a complex picture; on the one hand, no direct connection was found between anti-COVID-19 drug treatment and the development of variants. On the other hand, the researchers discovered that it is likely the weakened immune system of immunocompromised patients that creates pressure for the virus to mutate.
In fact, the researchers found that there were chronic patients who showed a pattern of apparent recovery, followed by recurring viral infection. In all of these patients, a mutated form of the virus emerged, suggesting that recovery had not been achieved; this is partially reminiscent of the modus operandi of HIV following inadequate drug treatment.
Upon closer examination of some patients, the researchers found that when such a pattern of apparent recovery is observed (based on negative nasopharyngeal swabs), the virus continues to thrive in the lungs of the patients. The researchers, therefore, suggest that the virus accumulates mutations in the lungs, and then traverses back to the upper respiratory tract.
Prof. Stern concludes: “The complexity of coronavirus evolution is still being revealed, and this poses many challenges to the scientific community. I believe that our research has succeeded in peeling back a missing layer of the big picture, and has opened the door for further research efforts to discover the origins of the various variants. This study highlights the importance of protecting immunocompromised individuals, who are at high risk for the virus, yet may also be an incubator for the formation of the next variant, posing a risk to all of us.”
Reference: “Drivers of adaptive evolution during chronic SARS-CoV-2 infections” by Sheri Harari, Maayan Tahor, Natalie Rutsinsky, Suzy Meijer, Danielle Miller, Oryan Henig, Ora Halutz, Katia Levytskyi, Ronen Ben-Ami, Amos Adler, Yael Paran, and Adi Stern, 20 June 2022, Nature Medicine.
DOI: 10.1038/s41591-022-01882-4
Heliobas Disciple
TB Fanatic
In Memory of Dr. Vladimir Zev Zelenko ⋆ Brownstone Institute
In his four years of struggle with what was a terminal cancer, Dr. Zelenko looked death in the eye numerous times.
brownstone.org
In Memory of Dr. Vladimir Zev Zelenko
By Harvey Risch
July 2, 2022
Dr. Zev Zelenko had both moral and intellectual courage in a society dominated by go-along-to-get-along. Dr. Zelenko was an astute physician, keenly aware of the nuances in disease presentations of his patients. They came to him for treatment of the respiratory disease that would become Covid-19.
Dr. Zelenko’s mind was always active in thinking about the best ways to care for his patients, and in the absence of established methods of treatment, he searched for what other clinicians had been doing for this and similar respiratory infections.
In Korea, doctors had been using chloroquine or hydroxychloroquine–in fact, this agent was known to be effective in the SARS-CoV-1 era–so he adopted that. He knew that zinc had been suggested to help in respiratory virus infections. And he found that doctors in Marseille had been using the antibiotic azithromycin in regimens to treat Covid patents.
So he incorporated all three as the basis for his initial outpatient treatment recipe, for patients who he classified as “high risk”–the remainder not needing treatment as they would recover well on their own. After treating 400 high-risk patients and having only one, who started the medications late and didn’t continue, hospitalized, he recognized that this recipe was highly effective in treating the respiratory infection early.
But Dr. Zelenko didn’t keep this to himself. He informed numerous other doctors, as well as the Trump Administration, about how well his early treatment worked.
President Trump’s public announcement is claimed to have politicized this treatment regimen, but that assertion can only be considered to be an infantile response if indeed the treatment worked. However, Dr. Zelenko, like the rest of us, did not understand that suppression of effective generic medications against Covid had started well before President Trump said anything, in fact, before Dr. Zelenko formulated his treatment protocol or even the first cases of Covid were recognized in the US.
When his treatment recipe received massive fraudulent pushback in the regular media, in social media, by academic doctors (who however had never themselves treated any Covid outpatients), he understood that there was a major campaign to discredit him, to suppress his treatment in order to pave the way for patent agents to compete in an economic marketplace where an effective and safe $20 treatment would severely curtail their market share.
But economic considerations do not alter the underlying truth about whether a medication regimen works for its intended treatment. Dr. Zelenko was zealous for truth.
Thus, he steadfastly maintained his public position that hydroxychloroquine-based early treatment regimens were effective for outpatient Covid, and grew to understand that this fact was a major obstacle for the pharma and vaccine manufacturers who would think it nothing to spend billions of dollars to manipulate and corrupt the marketplace and medical and lay media against his treatment, and later against ivermectin as well. He fought this battle to the end of his life.
In his four years of struggle with what was a terminal cancer, Dr. Zelenko looked death in the eye numerous times. He said that these experiences made him unafraid of the opinions of men. But I think that he had a strength of character that enabled him to get to that point, separate from his own illness, that surely made him unique.
He was a dear friend, colleague and leader to me. His legacy will live on, for indeed a blessing on society.
Heliobas Disciple
TB Fanatic
Springtime for Stillbirths in Germany
Don't be stupid, be a smarty, come and join the vaccine party!
jackanapes.substack.com
Springtime for Stillbirths in Germany
Winter for women and babes
Josh Guetzkow
10 hr ago
I just received FOIA’d data on stillbirths in Germany from my friend and colleague, Prof. Christof Kuhbandner and share them with his permission. The picture they reveal is jaw-dropping. The graph below shows the monthly percent change in stillbirths in 2021-2022 compared to the monthly average from 2019-2020:
Comparison with earlier years is problematic because Germany changed the way it defined stillbirths at the end of 2018.1
It really doesn’t matter. The pictures is consistent with this graph on stillbirths and neonatal deaths in Scotland:
The German stillbirth data is also consistent with this graph showing a big decline in German births in the first quarter of 2022:
Here is a troubling table of US monthly birth rates in 2022 compared to 2021 in US states, courtesy of baizuobo:
Igor Chudov also reported on a 23% decline in the Taiwanese birth rate in May, 2022 compared to the previous year. Similar troubling declines can be seen in this table, also shared on Twitter by an account under the name @BirthGauge:
The best one can say about this table is that we don’t see declines in every country, which leaves some room for hope that the declines are not due to the mass injections of novel gene therapy technology but rather to something else. I know I’m grasping at straws. But it’s all I’ve got to cling to right now.
1 The official comment that accompanied the data file Christof received was:
"We would also like to point out that the definition of stillbirths was last changed as of 11/1/2018, which tends to increase the numbers. Until October 2018, a child was considered stillborn if it weighed at least 500 grams. Since November 2018, a stillbirth is also considered when the child was below this weight limit but had reached the 24th week of pregnancy.
Further, we note that the results for 2021 and 2022 are preliminary as well as accrued by date of reporting. Compared to the final results, which reflect the date of deaths, these preliminary ones tend to be too low at the beginning of the year and too high at the end of the year."In addition, Christof wanted me to be sure to note that:
In other words, the stillbirth data for the years 2021 and 2022 are based on the reporting date and not on the death date, that is, the time trend has to be interpreted with caution. Especially for the number of stillbirths for the most recent months, there might still be late registrations, which would things make even worse
Here is a link to the source data for the German stillbirths from the FOIA. An Excel file with data on live births is here or you can get from original source here.
Heliobas Disciple
TB Fanatic
Sweden's Birth Rate Dropping Precipitously Every Month
A very unusual pattern this year -- 9 months after young people vaccinated
igorchudov.substack.com
Sweden's Birth Rate Dropping Precipitiously Every Month
A very unusual pattern this year -- 9 months after young people vaccinated
Igor Chudov
16 hr ago
Sweden, a good country that cares about its citizens, publishes up-to-date birth statistics.
The statistics are very concerning and show a deepening decline in births this year. It is actually WORSE than it looks on this chart, as I will show later.
I have tabulated this data:
And here’s a more visual graphical presentation of the DROP in births in Sweden, by month:
You can see that not only is the drop in births in Sweden significant, but it is also gradually deepening every month! It looks as if an inexorable force is preventing previously healthy Swedes, who plan families and are encouraged by their government to have children, from actually conceiving and completing their pregnancies.
What could cause this?
Vaccination of Young People in Sweden
Take a look at this helpful chart from Our World in Data. Go back 9 months and look at the younger 18-49-year-old categories. Look at their vaccination progress from April to August 2021:
Young people of Sweden were assured by the Swedish authorities that Covid vaccines are definitely very safe and effective. Swedes, especially young people, trust their government. So, they took Covid vaccine shots, did not think much about them, and continued whatever they were doing, such as making babies, just like the Swedish government encouraged them to do.
They probably did not notice that the number of pregnancies was dropping.
What About Other Countries?
Sweden is NOT alone. I reported on a dramatic (and similar to Sweden) decline in births in Germany, Switzerland, North Dakota, and the UK:
Taiwan, which also vaccinated young people 9 months prior, is recording a whopping 23% drop in birth rates! Such a drop is a depopulation-level event if this trend continues.
Cannot Blame Lockdowns
Sweden is also a very interesting case because this country was never locked down. So people were free to party, date, have fun, and so on, just like always. If you could possibly place blame on “lockdowns” for other countries, Sweden proves that lockdowns are NOT the cause — since it never locked down its citizens.
Mind you, 9 months ago, less than half of young Swedes were vaccinated. None yet received vaccine boosters.
What will happen to Sweden’s birth rate months from now, with the childbearing age people getting more vaccines and more boosters 9 months prior? Young people ended up being 80% vaccinated in Sweden and many were later boosted. I, naturally, hope that this disturbing trend will somehow disappear, but I fear that it will worsen.
It is time to start worrying and sound some alarms. Are you worried?
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Heliobas Disciple
TB Fanatic
swedish birth rate data: what does it really show us?
digging in to see if this drop is truly unusual
boriquagato.substack.com
swedish birth rate data: what does it really show us?
digging in to see if this drop is truly unusual
el gato malo
11 hr ago
there has been a great deal of talk about swedish birth rate data (among many other countries) in 2022.
i think sweden provides a particularly interesting lab/test case for a number of reasons:
1. they provide good data
2. it goes back 25 years
3. they did not engage in much lockdown so that is not a confounding factor to the extent it is in most of the rest of the west
there seem to be two competing lines of argument:
- some are pointing to precipitous drops in recent months and claiming this is a highly unusual outcome.
- others are claiming this is no big deal and that there is always variability like this.
as ever, the one way to find out is to roll up your sleeves and dig some data.
so here we go:
i took THIS SERIESfrom the swedish statistical agency and worked with it. it has data by month back through 2019 and per year back to 1998.
to eliminate the effects of population growth i took all live births data and divided by population to get births per million population. all data is presented that way.
i like to start with raw data in full series to get a sense of what one is looking at. so this is all data per month from 2019-april 2022.
from the look of this chart, nothing terribly unusual is going on. this seems to be a key aspect of the “normal variability” argument.
but i think this is extremely misleading and those using it to say so are getting it wrong. here’s why: the signal is highly seasonal, and when you line it up that way, 2022 really pops.
you can see this another way here:
2022 really is quite a lot lower. and if we look at this as % change from prior year, you can really see the delta.
birth rates are collapsing far in excess of normal or any prior point and this rate of decline is accelerating.
of course, one can also argue that this is a very short time period and thus perhaps not terribly meaningful. i think this is a fair criticism.
so let’s zoom out:
the data is only available by year (not month) pre 2019 (though if someone knows where to find monthly, i’d LOVE to see it)
i looked at the data from 2019, 2020, 2021 and noticed something interesting:
the % of births in jan-apr relative to the year as a whole was remarkably constant.
it was 33.6%, 33.7%, and 33.3% respectively.
that’s a very tight range, tight enough to make what felt like meaningful extrapolation.
so, i took their avg (33.5%) and used it to predict 2022’s full value.
i marked it in red on the graphs to ensure that people realize it’s an estimate.
this is a BIG move.
it’s easier to see when looked at as % change from prior year.
there has been nothing like this in the last 25 years.
the next biggest drop was barely half this size and that was a significant outlier too.
we’re on the order of 2X the divergence of the biggest previous outlier in 25 years at -7.5% in a system where being under -2% is a sub 10% occurrence.
so, unless this jan-apr ratio changed wildly in a manner not seen in recent years, we’re looking at something pretty extreme.
based on what i’m seeing here, the birth rate drop is quite real and quite unusual.
it starts in earnest in jan 2022. that means babies that were conceived in april 2021. it’s accelerating into april (babies conceived in july 2021).
and look what was going on then that had never happened in sweden before:
correlation does not prove causality, but this kind of fit when we already have an a priori reason to suspect fertility impact from completely independent biological testing is more than a little provocative.
discussion here:
whether or not this reverses is an interesting question.
it looked to me like 20-40% of those jabbed saw near total suppression even at ~6 months. this would imply that we are nowhere near peak fertility decline (but also may be very hard to map to society scale).
- so if this is vaxx driven, it’s likely to persist all through 2022 at the very least.
- the effect is large and unprecedented in the data for 25 years as far as i can see (though admittedly, having a full 25 year series by month would provide more clarity)
- the alignment on hypothesized cause and effect is extremely precise.
- and we have a priori reason to suspect the relationship based on hard biological science.
all in all, i think this makes the case that sweden is just experiencing normal variability look very weak and the the case for a vaccine driven effect look quite strong.
that is NOT what i was hoping to find. if this is what it looks like, this is very bad news.
but the thing about data is you have to follow it where it leads.
otherwise you’re just making stuff up.
will keep on this. seems like very important issue to get to the bottom of.
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Heliobas Disciple
TB Fanatic
Covid shots for little kids are DOA
The fawning media coverage notwithstanding, uptake has been pitifully low.
alexberenson.substack.com
Covid shots for little kids are DOA
Alex Berenson
18 hr ago
Despite a massive media and government pressure campaign, American parents are overwhelmingly rejecting Covid vaccines for their young children.
About one week after the shots became available, barely 1 percent of children under 5 have received mRNA jabs for Covid, data from several states show.
Ohio:
Even in California, among the bluest states, only about 2 percent of kids under 5 have been jabbed.
Demand is likely to be near zero going forward. The recent history of Covid shots shows that the increasingly tiny minority of mRNA fanatics get themselves or their children jabbed or boosted quickly after regulators okay new doses. So pent-up desire for new shots is likely nonexistent.
As usual, elite media outlets have largely refused to acknowledge this reality, instead running endless articles that seek to normalize and encourage the shots.
(CNN gonna CNN: )
But at this point many parents have seen and experienced the side effects of the vaccines for themselves. They also know firsthand that the shots do little if anything to stop Omicron infections (though they may not be aware how terrible the data truly are). And they know that Covid is a minuscule risk for children who are not already seriously ill, and that most kids have already been exposed.
(All the Sesame Street ads in the world can’t change reality. Congrats, Elmo. You’re in the 1 percent. Cute Band-Aid, though.)
But as it becomes clear just how few little kids have gotten the shots, any future media and public health pressure campaigns will look embarrassingly out-of-touch.
Someone may want to tell the Biden Administration: the less said about the pathetic decision to make these shots available for kids under 5, the better.
Oh, wait, too late.
Uncle Joe wins again!
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Heliobas Disciple
TB Fanatic
OF BATS, CORONAVIRUSES AND EXTREME HUMAN (INFLAMM)AGING: WHY BAT CORONAVIRUSES ARE HUMAN NEUTRON BOMBS: MCC950 TO THE RESCUE
Depopulation and GOF Research: Is MCC950 Our Savior?
wmcresearch.substack.com
OF BATS, CORONAVIRUSES AND EXTREME HUMAN (INFLAMM)AGING: WHY BAT CORONAVIRUSES ARE HUMAN NEUTRON BOMBS: MCC950 TO THE RESCUE
Depopulation and GOF Research: Is MCC950 Our Savior?
Walter M Chesnut
5 hr ago
The world has been involved in heated and virulent (pun intended) debate over the origins of SARS-CoV-2. There have been scientists involved in explaining with great detail how this virus MUST be from a lab, and then there have been “scientists” that will defend to the death, and in the face of overwhelming evidence, that the virus has “naturally” evolved.
Regardless of where one stands (I don’t see how there are any options) with regards to the origins of the virus, one thing is absolutely certain. The United States has been funding gain of function research on Bat Coronaviruses both domestically and (when it became illegal to do so here) at the Wuhan Institute of Virology and other international locations.
Yet, nobody seems to have asked a very fundamental question: WHY is it that BAT coronaviruses have been targeted for such extreme study and manipulation?
The answer is found in the bat’s immune response to this type of virus.
NLR family pyrin domain containing 3 (NLRP3) is an important sensor that recognizes both cellular stresses (such as extracellular adenosine triphosphate (ATP), mitochondrial damage and oxidized DNA) and viral or bacterial infections. NLRP3-mediated inflammation has been causally linked to aging and multiple age-related chronic diseases. Over-activation of the NLRP3 inflammasome has been linked to a hyper-inflammatory state and immunopathology in viral infection with MINIMAL EFFECT ON THE VIRAL LOAD.
If we analyze NLRP3 inflammasome activation in humans and bats in (peripheral blood mononuclear cells) PBMCs, primed with LPS for 3 h, with or without stimulation by ATP or nigericin for 30 min, we notice a MASSIVE difference in the activation of this inflammasome within humans.
What is most disturbing is that when exposed to MERS-CoV, humans have massive NLRP3 activation and ASTRONOMICAL levels of IL-1B, one of the most consistently upregulated cytokines in cachexia and other aging-related diseases.
What I find fascinating, and hopeful, is that when human cells are primed with MCC950, THE NLRP3 INFLAMMASOME ACTIVATION AND IL-1B LEVELS ARE NOT SIGNIFICANT!!!
Why is MCC950 so important?
MCC950 significantly suppressed release of proinflammatory cytokines IL-1β, IL-18, IL1-α, IFNγ, TNF-α, IL6, IL17, chemokine MIP1a and Nitric Oxide in colonic explants.
Why has this therapeutic not been trialed in COVID-19 treatment?
Back to the depopulation and GOF game being played.
If a bat virus can induce such a massive amount of inflammaging age acceleration, how do you get it into humans?
YOU CREATE A SPIKE THAT HAS A PIT BULL ATTACK AFFINITY TO ACE-2!!!!!
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host - Nature Microbiology
Dampened activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in bat primary immune cells in response to infection with multiple zoonotic viruses is caused by decreased transcriptional priming, the presence of a unique splice variant and an altered leucine-rich repeat...
www.nature.com
The interplay of immunology and cachexia in infection and cancer
The interplay of immunology and cachexia in infection and cancer - Nature Reviews Immunology
The causative mechanisms of cachexia, a complex catabolic syndrome that can occur in the context of malignant or infectious diseases, are poorly understood. This Review examines the immunological context of cachexia and explores immunometabolic crosstalk both upstream and downstream of tissue...
www.nature.com
MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice
MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice - Scientific Reports
MCC950 a potent, highly specific small molecule inhibitor of canonical and noncanonical activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven inflammatory diseases. However, the effect of MCC950 on colonic inflammation has not yet been reported. In the present study...
www.nature.com
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Heliobas Disciple
TB Fanatic
BOMBSHELL: Irrefutable Proof Of Premeditated Crimes Against Humanity
They always knew!
2ndsmartestguyintheworld.substack.com
BOMBSHELL: Irrefutable Proof Of Premeditated Crimes Against Humanity
They always knew!
2nd Smartest Guy in the World
18 hr ago
I was speaking with a colleague the other day, and we were debating whether CIA and NIH asset Ralph Baric and his co-conspirators at the Wuhan Virology Lab were knowingly attempting to induce Alzheimer’s disease (AD) with their COVID-19 bioweapon research.
The substack article we were referencing was written by Walter Chestnut in which he deduced that the lab-made Spike Protein causes Amyloid plaques and a dangerous “tangled” iteration of the protein called Tau.
When Tau tangles, or “tangled Tau” and beta-amyloid plaques accumulate in large enough numbers, these microscopic brain protein fragments impede a person’s ability to think and remember; this condition is diagnosed as AD.
Without getting too technical, I called this potential phenomenon Accelerated AD (AAD), concluding that AAD will impact all demographics that subjected themselves to the DEATHVAX™. Yes, even children.
Walter Chestnut made the following point:
However, it has since been discovered that the PRESENCE of Amyloid greatly ACCELERATES the deposition of Tau. This is most likely why the elderly, and those that have certain Amyloid-expressing conditions, experience more severe disease.
In naturally occurring cases of AD the amount of tangled Tau is around 1%, but with the introduction of the Spike Protein there is an hyper-production of tangled Tau. Tangled Tau is a misfolded or disordered protein, and as such is extraordinarily harmful.
Therefore, I believe the Spike Protein is inducing massive amounts of hyperphosphorylated Tau, which is creating the fibrils. This explains the AD, PD and even can explain the sudden cardiac deaths, as Tauopathies effect both the CNS and the peripheral autonomic nervous system.
Basically, the Spike Protein (especially the gene therapy variant which has two lab-made proline modifications, thus making it even more deadly over time) induces the endogenous production of fibriles which kick off a whole range of adverse events over time, and ultimately cause premature death.
All demographics will experience this “geriatric” disease, even children.
All demographics will experience premature death.
Walter Chestnut’s full article:
At the end of our conversation, I asked my associate if the bioweapon perpetrators specifically knew that they were targeting endogenous abnormal Tau production with their Gain of Function (GoF) research. My associate replied that he was 100% certain that they always knew about Tau, prion-based diseases, cardiac damage, etc.
The more toxic Tau buildup, the greater the AAD brain damage. The greater the AAD brain damage, the easier it is to control and depopulate said AAD brain damaged swaths of the population.
And now just a few days later we have incontrovertible proof; to wit:
To all the "good" scientists out there: 'have I read the paper below correctly, that the reaction between the host and hiv-1 gp120 glycoproteins can cause "amyloidosis"??' From Shibo Jiang 2014 @Jikkyleaks @jjcouey @CharlesRixey @Daoyu15 @MonaRahalkar Keith Evans @KeithEv84928885
Because there is a very good chance that the above tweet will at some point be taken down, I am posting the four screen shots and the link to the study that further establishes the crime.
Let’s start with the obvious: the year of publication was 2014.
Researcher 'Shibo Jiang' from Fudan University, Shanghai and the rest of the team were all CCP assets. They also happened to have ties with Dr. Mengele 2.0 aka Dr. Fauci and his NIH.
We know that COVID-19 had GoF HIV and TB insertions.
We know that the DEATHVAX™ causes VAIDS.
We also know that the Tau protein was discovered in 1975. By 1985 researchers had already linked Tau to abnormal protein deposits found in the brains of AD patients. Tau was proven to be one of the causes of intracellular neurofibrillary tangles.
By 2014 all researchers studying AD and Beta-amyloid fibrils knew about Tau. And researchers studying HIV-1 and virus attachments in relation to AD and Beta-amyloid fibrils all knew about the role Tau plays in neurodegenerative disease.
The CCP and NIH researchers also all knew that “amyloid fibriles play an important role in microbial infection.” Read that last part again.
Thus, they all knew they were infecting and transfecting people with AAD via their lab-made Spike Protein.
Enter Walter Chestnut again:
The very same CCP and NIH researchers always knew that their lab-modified Spike Protein cytotoxin would be a kind of self-replicating or self-generating Amyloidogenic protein.
The Modified mRNA gene therapy injection swaps out the Uracil component of the four naturally occurring RNA nucleobases for the synthetic Pseudouridine. The former lasts around 2 minutes in the body, while the latter lasts indefinitely.
Ergo, the lab-made Spike Protein of the DEATHVAX™ may be self-replicating indefinitely.
Ergo, tangled Tau production may be endogenously accelerating indefinitely.
Ergo, those that subjected themselves to the gene therapy are all experiencing Long COVID, even if they “feel” fine.
Long Covid may be premature AD, or AAD.
Ergo, those that subjected themselves to the gene therapy all have the dangerous tangled Tau endogenously slowly growing inside them as a direct function of the modified Spike Proteins that are perpetually being produced by the Modified mRNA and as such are persistently inducing the cascading neurological damage, even if they “feel” fine.
By the way, most AD sufferers “feel” fine, even while they are anything but.
Therefore, the researchers that created COVID-19 and the slow kill bioweapon injectables always knew exactly what they were devising.
They knew that this entire PSYOP-19 program would slowly but surely wipe out the planet, and what easier members of society to cull than those suffering from AAD?
The doubly infantilized — on the cultural (Death Cultist) and neurological (DEATHVAX™) levels — owning nothing in their frozen catatonic grins will all be happily depopulated off of the planet by the One World Government technocrats ushering in their 4th Industrial Revolution.
They always knew!
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Heliobas Disciple
TB Fanatic
WARNING: what we are seeing with BA.4 & BA.5 sub-variants/clades omicron; we warned that OMI was NOT nature's gift as we felt for a short time initially; NO, non-neutralizing Abs are devastating!
mRNA vaccine induced non-neutralizing antibodies (Ab) that enhances infectiousness of OMI in the upper respiratory tract, but same Abs block severe illness in lower respiratory tract; problem!
palexander.substack.com
WARNING: what we are seeing with BA.4 & BA.5 sub-variants/clades omicron; we warned that OMI was NOT nature's gift as we felt for a short time initially; NO, non-neutralizing Abs are devastating!
mRNA vaccine induced non-neutralizing antibodies (Ab) that enhances infectiousness of OMI in the upper respiratory tract, but same Abs block severe illness in lower respiratory tract; problem!
Dr. Paul Alexander
18 hr ago
All of this would stop if we stopped the COVID injections.
We are very concerned now that what we feared and warned is indeed happening especially in high risk persons, in that the prior blocking of severe illness in the lower respiratory tract (via non-neutralizing Abs) is being overcome and we are beginning to see illness in the lower lungs.
Geert began to warn and people like myself were explaining that we were seeing changes in the data whereby the very same non-neutralizing antibodies that were facilitating infectiousness in the URT (vaccinated getting infected) were blocking severe disease (transfection from infected to non-infected cells deep in the lung) in the lower respiratory tract (LRT), and appearing to prevent the formation of syncytia and this syncytia is reportedly correlated with severe disease.
The sub-optimal immune pressure by the non-neutralizing antibodies were behaving the same way in the URT and in time this pressure would be overcome in the LRT and this prior protection of severe disease would be overcome. In short, the prevention of formation of syncytia would stop. We are trying to model this out and understand more, but this seems to be occurring at some level.
We said that it was likely severe illness would emerge in time, and soon, and it is very concerning for we could face both infectious and virulent variants if the COVID injection is not stopped. It is the COVID injection that is doing this, not the virus. It is the injection and the vaccinal antibodies that are subsequently induced by the vaccine that are giving the virus problematic and dangerous properties, dangerous to the vaccinee. Enhanced infectiousness and now seemingly enhanced severity to vulnerable persons. We are courting disaster. We are doing this and the persons in public health and pharma are creating a potentially devastating situation with these failed injections.
I share this study that helps understand syncytia and bear with us as we try to explain what is happening based on the data and how the virus host interactions are unfolding. It is not only due to properties intrinsic to the virus. It’s the interplay between virus and host immune system, and in this case, the massive role of the non-neutralizing vaccinal antibodies pressuring the spike antigen.
SOURCE:
Syncytia formation by SARS-CoV-2-infected cells
“Severe cases of COVID-19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms regulating the formation of these syncytia are not well understood. Here, we show that SARS-CoV-2-infected cells express the Spike protein (S) at their surface and fuse with ACE2-positive neighboring cells. Expression of S without any other viral proteins triggers syncytia formation…Our results show that SARS-CoV-2 pathological effects are modulated by cellular proteins that either inhibit or facilitate syncytia formation.”
Note: Pneumocytes are the epithelial cells that line the alveolar cells of the lungs.
Also, some are thinking now BA.4 and BA.5 may be entirely new viruses, not clades off of omicron master. Sharing this too.
.
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"COVID-19 is still killing hundreds of Americans each day, but is not nearly as dangerous as it was last fall and winter":, we say NO, do not be fooled, there is massive infectiousness in URT and
blocked severe illness in LRT, but this is and can change, and it is due to the sub-optimal vaccinal immune pressure due to non-neutralizing Abs onto the spike; be warned! must stop VAX!
palexander.substack.com
"COVID-19 is still killing hundreds of Americans each day, but is not nearly as dangerous as it was last fall and winter":, we say NO, do not be fooled, there is massive infectiousness in URT and
blocked severe illness in LRT, but this is and can change, and it is due to the sub-optimal vaccinal immune pressure due to non-neutralizing Abs onto the spike; be warned! must stop VAX!
Dr. Paul Alexander
15 hr ago
Stop the COVID injections NOW!!!!!!!!!!!!!!! Do not touch our children with these! Do not tamper with functional potent innate immunity in our kids.
I plead, just properly protect the vulnerable, use Vit D3, use early treatment, use prophylaxis, ventilate your environment, and let the rest of society live normal lives! Stop the COVID injection, it is prolonging the pandemic and driving the emergence of an infectious and lethal variant, at once.
We only get to herd immunity if we cut the chain of transmission; these vaccines induce non-neutralizing Abs that do not neutralize the virus and stop infection, in fact, as per Yahi et al. (Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?), it facilitates infection in the vaccinated. Thus we cannot get to herd immunity.
It is either the infectious pressure from the circulating virus is reduced urgently or the vaccine is stopped. One of the two else the pandemic will last forever and the people, the pharma, the public health officials doing this know this. The irony is the more we vax, the more infection is produced. It is ridiculous and dangerous and Fauci and Bourla and Walensky and Francis Collins and Tam and Njoo know this. They know the disaster they are creating.
Do not be fooled, this reprieve or ‘nature’s gift’ (even Geert, Yeadon, Cole, McCullough, and I…we were initially fooled until we studied it deeply) is a wolf in sheep clothing, a Trojan Horse, as very serious LRT disease has started to emerge and these clowns are failing to understand the interplay between the virus and the host immune system and especially the role of the non-neutralizing Abs and the sub-optimal mounting immature immune pressure on spike (receptor binding domain and/or N terminal domain epitopes).
The pharma Pfizer and Moderna and these health officials at CDC, NIH, FDA etc. are either the most inept stupid people on earth, in virology and immunology etc. or are corrupted, bought out, or malfeasant. Chose. I say they are all.
SOURCE
For now, wary US treads water with transformed COVID-19
.
jward
passin' thru
Are the Covid mRNA Vaccines Safe? ⋆ Brownstone Institute
Martin Kulldorff
8-11 minutes
A new scientific study entitled “Serious adverse events of special interest following mRNA vaccination in randomized trials” provides the best evidence yet concerning the safety of the mRNA Covid vaccines. For most vaccines in common use, benefits far outweigh risks, but that may not be the case for the mRNA covid vaccines, according to this study by Joseph Fraiman and his colleagues. It depends on your age and medical history.
The randomized controlled clinical trial is the gold standard of scientific evidence. When regulators approved the Pfizer and Moderna mRNA vaccines for emergency use in December 2020, two randomized trials showed that the vaccines reduced symptomatic covid infection by over 90% during the first few months after the second dose.
Pfizer and Moderna did not design the trials to evaluate long-term efficacy or the more important outcomes of preventing hospitalization, death, or transmission.
The randomized trials did collect adverse event data, including the presence of mild symptoms (such as fever) and more serious events requiring hospitalization or leading to death. Most vaccines generate some mild adverse reactions in some people, and there were considerably more adverse such reactions after the mRNA vaccines compared to the placebo.
That is annoying but not a major issue. We care about severe health outcomes. The key question is whether the vaccine’s efficacy outweighs the risks of severe adverse reactions.
The Fraiman study uses data from the same Pfizer and Moderna-sponsored randomized trials presented to the FDA for vaccine approval, but with two innovations that provide additional information.
First, the study pools data from both mRNA vaccines to increase the sample size, which decreases the confidence intervals’ size and the uncertainty about the estimated harms.
Second, the study focuses only on the severe adverse events plausibly due to the vaccines. Serious adverse events such as gunshot wounds, suicide, animal bites, foot fractures, and back injury are unlikely to be due to a vaccine, and cancer is unlikely to be due to a vaccine within a few months after vaccination. By removing such random noise, the ability (statistical power) to detect genuine problems increases. If there is no excess risk, shorter confidence intervals bolster confidence in the safety of the vaccines.
Classifying adverse events into the two groups is not a trivial task, but Fraiman et al. do an excellent job to avoid bias. They rely on the pre-defined Brighton Collaboration definitions of adverse events of special interest (AESI). Founded in 2000, the Brighton Collaboration has two decades of experience using rigorous science to define clinical outcomes for vaccine safety studies.
Moreover, Fraiman and colleagues blinded the process where they classified the clinical events as AESIs. Adjudicators did not know whether the individual had received the vaccine or the placebo. Hence, any criticism of so-called p-hacking is unwarranted.
So, what are the results? There were 139 AESIs among the 33,986 people vaccinated, one for every 244 people. That may sound bad, but those numbers mean nothing without comparison against a control group. There were 97 AESIs among the 33,951 people who received a placebo. Combining these numbers implies 12.5 vaccine-induced AESIs for every 10,000 people vaccinated, with a 95% confidence interval of 2.1 to 22.9 per 10,000 people. To phrase it differently, there is one additional AESI for every 800 people vaccinated (95% CI: 437-4762).
That is very high for a vaccine. No other vaccine on the market comes close.
The numbers for the Pfizer and Moderna vaccines are 10 and 15 additional events per 10,000 people, respectively, so both vaccines contributed to the finding. The numbers are similar enough that we cannot confidently say that one is safer than the other. Most excess AESIs were coagulation disorders. For the Pfizer vaccine, there was also an excess of cardiovascular AESIs.
While these safety results are concerning, we must not forget the other side of the equation. Unfortunately, the study does not calculate composite estimates that also included the reduction in serious covid infections, but we have such estimates for mortality.
Dr. Christine Benn and her colleagues calculated a combined estimate of the effect of vaccination on all-cause mortality using the same randomized trial data as Fraiman et al. They did not find a mortality reduction for the mRNA vaccines (relative risk 1.03, 95% CI: 0.63-1.71).
One important limitation of both Fraiman’s and Benn’s studies is that they do not distinguish the adverse reactions by age, comorbidities, or medical history. That is not their fault. Pfizer and Moderna have not released that information, so outside researchers do not have access.
We know that the vaccine benefits are not equally distributed among people since covid mortality is more than a thousand times higher among the old. Thus, risk-benefit calculations must be done separately for different groups: with and without prior covid infection, by age, and for the first two doses versus boosters.
Critically, the Fraiman and Benn studies had a follow-up of only a few months after the second dose because Pfizer and Moderna, unfortunately, terminated their randomized trials a few months after receiving emergency use authorization. Of course, a longer-term benefit can provide a basis to tolerate negative or neutral short-term risk-benefit differences.
However, that is unlikely since we know from observational studies that mRNA vaccine efficacy deteriorates a few months after the second dose.
There may also be long-term adverse reactions to the vaccine regarding which we do not yet know. Since the randomized trials ended early, we must look at observational data to answer that question. The publicly available data from the Vaccine Adverse Event Reporting System is of low quality, with both under- and over-reporting. The best observational data is from CDCs Vaccine Safety Datalink (VSD) and FDA’s Biologics and Effectiveness Safety System (BEST), but there have only been limited reports from these systems.
Fraiman and colleagues have produced the best evidence yet regarding the overall safety of the mRNA vaccines. The results are concerning. It is the responsibility of the manufacturers and FDA to ensure that benefits outweigh harms. They have failed to do so.
brownstone.org
Martin Kulldorff
8-11 minutes
A new scientific study entitled “Serious adverse events of special interest following mRNA vaccination in randomized trials” provides the best evidence yet concerning the safety of the mRNA Covid vaccines. For most vaccines in common use, benefits far outweigh risks, but that may not be the case for the mRNA covid vaccines, according to this study by Joseph Fraiman and his colleagues. It depends on your age and medical history.
The randomized controlled clinical trial is the gold standard of scientific evidence. When regulators approved the Pfizer and Moderna mRNA vaccines for emergency use in December 2020, two randomized trials showed that the vaccines reduced symptomatic covid infection by over 90% during the first few months after the second dose.
Pfizer and Moderna did not design the trials to evaluate long-term efficacy or the more important outcomes of preventing hospitalization, death, or transmission.
The randomized trials did collect adverse event data, including the presence of mild symptoms (such as fever) and more serious events requiring hospitalization or leading to death. Most vaccines generate some mild adverse reactions in some people, and there were considerably more adverse such reactions after the mRNA vaccines compared to the placebo.
That is annoying but not a major issue. We care about severe health outcomes. The key question is whether the vaccine’s efficacy outweighs the risks of severe adverse reactions.
The Fraiman study uses data from the same Pfizer and Moderna-sponsored randomized trials presented to the FDA for vaccine approval, but with two innovations that provide additional information.
First, the study pools data from both mRNA vaccines to increase the sample size, which decreases the confidence intervals’ size and the uncertainty about the estimated harms.
Second, the study focuses only on the severe adverse events plausibly due to the vaccines. Serious adverse events such as gunshot wounds, suicide, animal bites, foot fractures, and back injury are unlikely to be due to a vaccine, and cancer is unlikely to be due to a vaccine within a few months after vaccination. By removing such random noise, the ability (statistical power) to detect genuine problems increases. If there is no excess risk, shorter confidence intervals bolster confidence in the safety of the vaccines.
Classifying adverse events into the two groups is not a trivial task, but Fraiman et al. do an excellent job to avoid bias. They rely on the pre-defined Brighton Collaboration definitions of adverse events of special interest (AESI). Founded in 2000, the Brighton Collaboration has two decades of experience using rigorous science to define clinical outcomes for vaccine safety studies.
Moreover, Fraiman and colleagues blinded the process where they classified the clinical events as AESIs. Adjudicators did not know whether the individual had received the vaccine or the placebo. Hence, any criticism of so-called p-hacking is unwarranted.
So, what are the results? There were 139 AESIs among the 33,986 people vaccinated, one for every 244 people. That may sound bad, but those numbers mean nothing without comparison against a control group. There were 97 AESIs among the 33,951 people who received a placebo. Combining these numbers implies 12.5 vaccine-induced AESIs for every 10,000 people vaccinated, with a 95% confidence interval of 2.1 to 22.9 per 10,000 people. To phrase it differently, there is one additional AESI for every 800 people vaccinated (95% CI: 437-4762).
That is very high for a vaccine. No other vaccine on the market comes close.
The numbers for the Pfizer and Moderna vaccines are 10 and 15 additional events per 10,000 people, respectively, so both vaccines contributed to the finding. The numbers are similar enough that we cannot confidently say that one is safer than the other. Most excess AESIs were coagulation disorders. For the Pfizer vaccine, there was also an excess of cardiovascular AESIs.
While these safety results are concerning, we must not forget the other side of the equation. Unfortunately, the study does not calculate composite estimates that also included the reduction in serious covid infections, but we have such estimates for mortality.
Dr. Christine Benn and her colleagues calculated a combined estimate of the effect of vaccination on all-cause mortality using the same randomized trial data as Fraiman et al. They did not find a mortality reduction for the mRNA vaccines (relative risk 1.03, 95% CI: 0.63-1.71).
One important limitation of both Fraiman’s and Benn’s studies is that they do not distinguish the adverse reactions by age, comorbidities, or medical history. That is not their fault. Pfizer and Moderna have not released that information, so outside researchers do not have access.
We know that the vaccine benefits are not equally distributed among people since covid mortality is more than a thousand times higher among the old. Thus, risk-benefit calculations must be done separately for different groups: with and without prior covid infection, by age, and for the first two doses versus boosters.
- Covid-recovered people have natural immunity that is stronger than vaccine-induced immunity. So, the benefit of vaccination is – at best – minimal. If the risk of adverse reactions is the same as in the randomized trials, there is a negative risk-benefit difference. Why are we mandating people in this group to be vaccinated? It is both unethical and damaging to public health.
- While everyone can get infected, children have a minuscule risk of covid mortality. There is very limited safety data from the trials on children. If the risk of adverse reactions is the same as for adults, the harms outweigh the risks. Children should not receive these vaccines.
- Older people above 70 have a much higher risk of covid mortality than the population in the Fraiman study. If their risk of adverse reaction is the same, then the benefits outweigh the harms. Hence, older people who have never had covid and are not yet vaccinated may benefit from these vaccines. However, we do not know if they are better than the Johnson & Johnson and Astra-Zeneca vaccines.
- It is unclear from the clinical trial data whether the benefits outweigh the risks for working-age adults who have not been vaccinated and who have not already had covid. This is true both historically, for the original covid variants, and currently for the newer ones.
- The Fraiman study analyzes data after the first and second doses. Both risks and benefits may differ for booster shots, but no randomized trial has properly evaluated the trade-off.
Critically, the Fraiman and Benn studies had a follow-up of only a few months after the second dose because Pfizer and Moderna, unfortunately, terminated their randomized trials a few months after receiving emergency use authorization. Of course, a longer-term benefit can provide a basis to tolerate negative or neutral short-term risk-benefit differences.
However, that is unlikely since we know from observational studies that mRNA vaccine efficacy deteriorates a few months after the second dose.
There may also be long-term adverse reactions to the vaccine regarding which we do not yet know. Since the randomized trials ended early, we must look at observational data to answer that question. The publicly available data from the Vaccine Adverse Event Reporting System is of low quality, with both under- and over-reporting. The best observational data is from CDCs Vaccine Safety Datalink (VSD) and FDA’s Biologics and Effectiveness Safety System (BEST), but there have only been limited reports from these systems.
Fraiman and colleagues have produced the best evidence yet regarding the overall safety of the mRNA vaccines. The results are concerning. It is the responsibility of the manufacturers and FDA to ensure that benefits outweigh harms. They have failed to do so.
-
Martin Kulldorff, Senior Scholar of Brownstone Institute, is an epidemiologist and biostatistician specializing in infectious disease outbreaks and vaccine safety. He is the developer of Free SaTScan, TreeScan, and RSequential software. Most recently, he was professor at the Harvard Medical School for ten years. Co-Author of the Great Barrington Declaration.
Are the Covid mRNA Vaccines Safe? ⋆ Brownstone Institute
Fraiman and colleagues have produced the best evidence yet regarding the overall safety of the mRNA vaccines. The results are concerning.
brownstone.org
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A viral reprise: When COVID-19 strikes again and again
Emerging research suggests that could put them at higher risk for health problems. U.S. Health and Human Services Secretary Xavier Becerra and Canadian Prime Minister Justin Trudeau said they got COVID-19 for the second time, and U.S. Sen. Roger Wicker of Mississippi said he tested positive a...
A viral reprise: When COVID-19 strikes again and again
LAURA UNGAR
Wed, June 29, 2022, 11:23 AM
For New York musician Erica Mancini, COVID-19 made repeat performances.
March 2020. Last December. And again this May.
“I’m bummed to know that I might forever just get infected,” said the 31-year-old singer, who is vaccinated and boosted. “I don’t want to be getting sick every month or every two months.”
But medical experts warn that repeat infections are getting more likely as the pandemic drags on and the virus evolves – and some people are bound to get hit more than twice. Emerging research suggests that could put them at higher risk for health problems.
There’s no comprehensive data on people getting COVID-19 more than twice, although some states collect information on reinfections in general. New York, for example, reports around 277,000 reinfections out of 5.8 million total infections during the pandemic. Experts say actual numbers are much higher because so many home COVID-19 tests go unreported.
Several public figures have recently been reinfected. U.S. Health and Human Services Secretary Xavier Becerra and Canadian Prime Minister Justin Trudeau said they got COVID-19 for the second time, and U.S. Sen. Roger Wicker of Mississippi said he tested positive a third time. All reported being fully vaccinated, and Trudeau and Becerra said they’d gotten booster shots.
“Until recently, it was almost unheard of, but now it’s becoming more commonplace” to have COVID-19 two, three or even four times, said Dr. Eric Topol, head of Scripps Research Translational Institute. “If we don’t come up with better defenses, we’ll see much more of this.”
Why? Immunity from past infections and vaccination wanes over time, experts say, leaving people vulnerable.
Also, the virus has evolved to be more contagious. The risk of reinfection has been about seven times higher with omicron variants compared with when delta was most common, research out of the United Kingdom shows. Scientists believe the omicron mutants now causing the vast majority of U.S. cases are particularly adept at getting around immunity from vaccination or past infection, especially infection during the original omicron wave. U.S. health officials are mulling whether to modify boosters to better match recent changes in the coronavirus.
The first time Mancini got COVID-19, she and her fiancé spiked fevers and were sick for two weeks. She couldn't get tested at the time but had an antibody test a couple months later that showed she had been infected.
“It was really scary because it was so new and we just knew that people were dying from it,” said Mancini. “We were really sick. I hadn’t been sick like that in a long time.”
She got vaccinated with Pfizer in the spring of 2021 and thought she was protected from another infection, especially since she was sick before. But though such “hybrid immunity” can provide strong protection, it doesn’t guarantee someone won’t get COVID-19 again.
Mancini’s second bout, which happened during the huge omicron wave, started with a sore throat. She tested negative at first, but still felt sick driving to a gig four hours away. So she ducked into a Walgreens and did a rapid test in her car. It was positive, she said, “so I just turned the car around and drove back to Manhattan.”
This bout proved milder, with “the worst sore throat of my life," a stuffy nose, sneezing and coughing.
The most recent illness was milder still, causing sinus pressure, brain fog, a woozy feeli and fatigue. That one, positive on a home test and confirmed with a PCR test, hit despite her Moderna booster shot.
Mancini doesn't have any known health conditions that could put her at risk for COVID-19. She takes precautions like masking in the grocery store and on the subway. But she usually doesn’t wear a mask on stage.
“I’m a singer, and I’m in these crowded bars and I’m in these little clubs, some of which don’t have a lot of ventilation, and I’m just around a lot of people,” said Mancini, who also plays accordion and percussion. “That’s the price that I’ve paid for doing a lot throughout these past few years. It’s how I make my living.”
Scientists don’t know exactly why some people get reinfected and others don’t, but believe several things may be at play: health and biology, exposure to particular variants, how much virus is spreading in a community, vaccination status and behavior. British researchers found people were more likely to be reinfected if they were unvaccinated, younger or had a mild infection the first time.
Scientists also aren’t sure how soon someone can get infected after a previous bout. And there's no guarantee each infection will be milder than the last.
“I’ve seen it go both ways,” said Dr. Wesley Long, a pathologist at Houston Methodist. In general, though, breakthrough infections that happen after vaccination tend to be milder, he said.
Doctors said getting vaccinated and boosted is the best protection against severe COVID-19 and death, and there's some evidence it also lessens the odds of reinfection.
At this point, there haven’t been enough documented cases of multiple reinfections “to really know what the long-term consequences are," said Dr. Peter Hotez, dean of Baylor University’s tropical medicine school.
But a large, new study using data from the U.S. Department of Veterans Affairs, which hasn’t yet been reviewed by scientific peers, provides some insight, finding that reinfection increases the risk for serious outcomes and health problems such as lung issues, heart disorders and diabetes compared with a first infection. The risks were most pronounced when someone was ill with COVID-19, but persisted past the acute illness as well.
After Mancini’s last bout, she dealt with dizziness, headaches, insomnia and sinus issues, though she wondered if that was more due to her busy schedule. In a recent week, she had 16 shows and rehearsals — and has no room for another COVID-19 reprise.
“It was not fun,” she said. “I don’t want to have it again.”
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COVID Cases Are "Rising Fastest" in These 5 States
The state of the COVID-19 pandemic continues to shift, as the highly contagious Omicron and its subvariants have crested in some areas and are rising rapidly in others. Health officials say it's important to know the level of community transmission in your area, so you can make informed choices...
COVID Cases Are "Rising Fastest" in These 5 States
Michael Martin
Sun, July 3, 2022, 7:31 AM
The state of the COVID-19 pandemic continues to shift, as the highly contagious Omicron and its subvariants have crested in some areas and are rising rapidly in others. Health officials say it's important to know the level of community transmission in your area, so you can make informed choices about preventative measures like masking and activities like large gatherings. These are the five states where COVID is rising the fastest. Read on to find out more—and to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.
Mississippi
According to the New York Times' COVID data tracker, the state's new COVID cases are up 54% in the last 14 days.
"Fortunately, we're not seeing the mortality impact," Dr. Thomas Dobbs, the state health officer, told MPB News this week. "Don't wanna underenforce the importance of getting treatment and everything, because we are gonna lose folks. And if it's that one person you love, it's 100% tragedy for you. But 95% plus of people have some immunity to COVID, so that's making all the difference."
Alabama
In Alabama, new cases are up 52% over 14 days ago. This comes the same week as a national scorecard on COVID response ranked the state last because of its low vaccination rate, hospital stress levels, and high numbers of excess deaths.
Montana
According to Times data, new COVID cases have risen 34% in Montana in the last 14 days. "We are definitely seeing an uptick. I think it's also important to remember that the numbers are only the reported numbers, but there are people who are positive and not testing or testing at home and not self-reporting, so not only are we seeing an increase in cases we know, the actual amount of cases is somewhere between a little higher to somewhere much higher," health official D'Shane Barnett told the Longview News-Journal on June 11. About 55% of the state's residents have been fully vaccinated against COVID, about 10% below the national average.
Louisiana
In Louisiana, new cases have increased 26% over two weeks ago. This week, health officials said the state is experiencing its sixth surge of COVID. "And thankfully as compared to prior surges, on average people are not getting very sick with this variety of COVID that's being spread right now," said state health officer Dr. Joe Kanter. "In prior surges, this amount of COVID out there would translate into a much larger degree of hospitalizations and deaths. We're thankfully not seeing that this time around." Health officials say of those hospitalized with COVID, 63% are not fully vaccinated, and 87% are not fully vaccinated or boosted.
Arkansas
New COVID cases in Arkansas are up 23% in the last 14 days, according to the Times tracker. State health officials urged residents to get their young children vaccinated against the virus. (Vaccines are now available for children as young as six months.) "These vaccines have been very well tested. We have a year and half worth of monitoring that we've done since the vaccine was first authorized in adults and in older teens," Dr. Robert Hopkins told THV 11.
How to Stay Safe Out There
Follow the fundamentals and help end this pandemic, no matter where you live—get vaccinated ASAP; if you live in an area with low vaccination rates, wear an N95 face mask, don't travel, social distance, avoid large crowds, don't go indoors with people you're not sheltering with (especially in bars), practice good hand hygiene, and to protect your life and the lives of others, don't visit any of these 35 Places You're Most Likely to Catch CO
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Several eastern Chinese areas in mass COVID testing to curb new waves of infections
SHANGHAI (Reuters) -Parts of eastern China are running fresh rounds of mass COVID-19 testing, as the country faces new waves of infections while recovering from impact of the spring outbreaks that hit Beijing and Shanghai. China continues to demand local authorities detect and contain new...
Several eastern Chinese areas in mass COVID testing to curb new waves of infections
by Roxanne Liu, Ryan Woo and Shanghai Newsroom; Additional writing by Liz Lee
Sun, July 3, 2022, 9:32 PM·2 min read
SHANGHAI (Reuters) -Parts of eastern China are running fresh rounds of mass COVID-19 testing, as the country faces new waves of infections while recovering from impact of the spring outbreaks that hit Beijing and Shanghai.
China continues to demand local authorities detect and contain new infections as soon as possible in its "dynamic COVID zero" strategy, although it has warned against expanding strict curbs unnecessarily as it struggles to revive the economy.
Daily numbers of locally transmitted infections in mainland China increased to more than 300 over the weekend compared with a few dozens in late June. While tiny by global standards, local officials have still closed some businesses and locked down more than a million people.
In the eastern province of Anhui, which reported most of China's local cases in the latest flare-up, its provincial capital Hefei said late on Sunday it is doing citywide testing every three days, after last month briefly scrapping weekly test requirements.
Anhui's Si town, where its 760,000 residents were told to stay home except for going out to do COVID tests, mandated citywide testing on Monday, its seventh round of mass testing.
Lingbi town, also in Anhui, locked down its nearly 1 million residents and said it had cancelled an event for local businesses to meet government officials.
In the southeastern province of Fujian, the Jiaocheng district and the town of Xiapu in the city of Ningde ran mass testing on Sunday.
Ningde, where the world's largest battery maker CATL is headquartered, reported 10 domestically transmitted COVID infections for Sunday, data from Fujian health authority showed on Monday.
Mainland China reported a total of 380 new local infections for July 3, of which 41 were symptomatic and 339 were asymptomatic, the National Health Commission said on Monday.
The infections were detected in the provinces of Anhui, Jiangsu, Liaoning, Fujian, Shandong, Shaanxi, Zhejiang, Guangdong and Sichuan, as well as in the city of Shanghai.
There were no new deaths, keeping the nation's reported fatalities at 5,226.
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CORONA - Main Coronavirus thread
How do you acquire the tablets? I didn’t I use the paste Much easier to acquire But from what I understand you can order tablets if you prefer from ivermectin.com
Macau steps up COVID testing as infections surge
by Farah Master
Sun, July 3, 2022, 8:38 PM·2 min read
HONG KONG (Reuters) -Macau kicked off a new round of COVID-19 testing for its more than 600,000 residents on Monday, as officials in the world's biggest gambling hub raced to limit spiralling infections in the city's worst outbreak since the pandemic began.
All residents face three rounds of tests this week, in addition to rapid antigen tests, as Monday's 68 new infections took the tally in the former Portuguese colony to 852 since the middle of June. About 12,000 people are in quarantine.
Although the Chinese special administrative region has not ordered a full-scale lockdown of the kind imposed in mainland cities such as the business hub of Shanghai, Macau is already largely closed.
Non-essential government services are shut, with schools, parks, sports and entertainment facilities closed, while restaurants may only provide takeaway items.
However, Macau has allowed casinos to stay open to ensure job security in an industry that generates more than 80% of government income by employing most of the city's population, whether directly or indirectly.
Still, punters are scarce and the casinos have very few staff, with many employees staying home in line with a government directive.
Analysts said the six operators, Sands China, Wynn Macau, MGM China, Melco Resorts, Galaxy Entertainment, SJM Holding are likely to have no income for several weeks beause of the measures.
Macau had been largely free of COVID-19 since an outbreak in October 2021. It follows China's "zero-COVID" policy that aims to eradicate all outbreaks at just about any cost, but runs counter to a global trend of trying to co-exist with the virus.
Its infections are still far below those elsewhere, including the neighbouring global financial hub of Hong Kong, which has seen daily cases jump to more than 2,000 this month.
However, the services of its sole public hospital are severely stretched. The territory has an open border with mainland China, with many residents living and working in the adjoining city of Zhuhai.
About 600 Chinese health workers have come to Macau to assist coronavirus efforts. Officials have set up a makeshift hospital next to the city's Las Vegas-style Cotai strip to help cope.
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Germany's Scholz sees no COVID-related school closures, lockdowns
Germany will not shut schools and non-essential businesses again if the COVID-19 infection rate rises again later this year but protective masks would play a bigger role, Chancellor Olaf Scholz told broadcaster ARD on Sunday. The infection rate in Germany has been on the rise for the past...
Germany's Scholz sees no COVID-related school closures, lockdowns
by Sarah Marsh
Sun, July 3, 2022, 7:04 AM
BERLIN (Reuters) - Germany will not shut schools and non-essential businesses again if the COVID-19 infection rate rises again later this year but protective masks would play a bigger role, Chancellor Olaf Scholz told broadcaster ARD on Sunday.
The infection rate in Germany has been on the rise for the past month, reaching close to 700 new cases per 100,000 residents this week, after falling below 200 in late May, but Scholz said that vaccinations should help limit what measures will be needed to curb the spread of the virus.
There should not be school closures again, and I also don't think that we will need the kind of lockdowns we had several times in the last couple of years," he told ARD in an interview.
"But I believe that you can expect that masks will play a bigger role again in the autumn and winter than they do now," he added.
Scholz, who has so far not been infected with COVID-19, said he would recommend that anyone over 60 years of age should seek a fourth shot of COVID-19 vaccine, as he had.
"Maybe the fact that I have been vaccinated four times is the reason that it (an infection) hasn't happened," he said.
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Heliobas Disciple
TB Fanatic
Here is another link to the video between Geert and Dr. McMillan.
StreamYard | Browser-based live studio for professionals
Engage your Facebook, or YouTube, Live audience with interviews and shows; all the tools you need for professional shows right in your browser.
If you want to download it, here is the link. Just right click on it and then choose 'save video as' and name it and you can download it to watch later. This has an expiration date in the header so I don't know how long it will work. So I suggest you use it when you see this if you do want to download.
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Heliobas Disciple
TB Fanatic
Hungary: Highest Vaccinated Counties Have Worst Birth Rate Drops!
Budapest is the new Taiwan -- Birth Rate Drop of -22.2%!
igorchudov.substack.com
Hungary: Highest Vaccinated Counties Have Worst Birth Rate Drops!
Budapest is the new Taiwan -- Birth Rate Drop of -22.2%!
Igor Chudov
13 hr ago
Interesting news on the birth rate drop front! It turns out that the most vaccinated counties of Hungary have the worst drop in birth rates in 2022! This is a within-country comparison, comparing Hungarians to Hungarians, for the same time period.
Thanks to my incredible reader “handyman” and Twitter user @overcatbe, I came across two pieces of data:
- Vaccination Rate in Hungary by county as of July 13, 2021 (archive link)
- Change in Birth Rate in Hungary by County for Q1 2022 (archive link)
Unfortunately, this data is noisy, as it presents only a single-moment snapshot of vaccination rates, and they are not super dissimilar. To make the comparison less noisy, I decided to pick five MOST vaccinated counties, and five LEAST vaccinated counties. The idea is to compare changes in birth rates among the most divergent counties, eliminating some amount of noise, driven by little-different counties.
Before I go further, I have to remind my readers: birth rates are always seasonal! Most parents prefer to make a “spring baby”, which often ends up with them making a “summer baby” because conception takes more time than expected. So, never compare adjacent quarters as they are guaranteed to have dramatic changes that are simply seasonality-driven, with differences very repeatable over the years. Only compare quarters of one year with same quarters of another year, please.
My own birth rate comparison compares Q1 of 2022, against Q1 of 2021. Since they are within-country comparisons, we can be more confident that they are driven by vaccination rates, as opposed to political, economic, or ethnic differences. These people are all Hungarians.
So, here are the 5 most vaccinated counties, contrasted with the 5 least vaccinated counties.
You can see that the five least vaccinated counties experienced only a 4.66% drop in birth rates between Q1 of 2021 and Q1 of 2022. At the same time, five most vaccinated counties experienced a 15.2% drop in birth rates! (NOTE: birth rate decline numbers are averaged without weighing by population. Our astute reader Richard Zucker commented and calculated the decline based on the number of total births for the most-vaccinated group and it is -17.4%, an even more impressive drop)
This is a tremendous 10.5% difference between birth rate outcomes! Put in other words, the birth rate decline in most heavily vaccinated Hungarian counties was THREE TIMES greater than the decline in least-vaccinated counties!
This is an apples-to-apples, Hungarians-to-Hungarians, same time period comparison! Pretty much the only variable is the extent to which those counties vaccinated their citizens by July 2021, including young people likely to make babies. Again, to remind you: the vaccination rates are a snapshot for July 13, 2021. You can add 9 months to July 2021, which gives you April 2022. Thus, you can see why birth rates in Q1 2022 changed: because of Covid vaccination.
The result? The more vaccination, the greater the declines in the birth rates.
Here’s a good looking Hungarian parliamentarian asking questions about what happened to her country:
Igor Chudov @ichudov
Oops, Hungary's birth rate falls 20% after mandated experimental treatments began 9 months prior in Hungary. If you like smart and sexy cisgender female presenters, watch this video of Hungary Parliament hearing. The dominoes are falling! rumble.com/v1ampa7-hungar…
Oops, Hungary's birth rate falls 20% after mandated experimental treatments began 9 months prior in Hungary. If you like smart and sexy cisgender female presenters, watch this video of Hungary Parliament hearing. The dominoes are falling! rumble.com/v1ampa7-hungar…
July 2nd 2022
41 Retweets102 Likes
41 Retweets102 Likes
Q.E.D.
For more interesting news regarding drops in birth rates this year, see my series:
- Sweden (dramatic steady decline to -10% this year)
- Taiwan (-23% decline)
- Germany, North Dakota, UK, and Switzerland. (12-13% declines)
It is becoming fairly apparent that the 2022 fertility drops are the true “black swans” of demographics, unprecedented in the breadth of countries involved, very large, deepening, extremely statistically significant, and very worrying.
A big question of the day is: is this a temporary situation or will the declines be permanent? If they are permanent, it may lead to depopulation of affected countries!
The answer is UNKNOWN to me and is also unknown to anyone else. Beware of vaccine advocates saying “birth rate declines are temporary and no big deal, the vaccine is working as expected”. Beware of vaccine skeptics jumping the gun and proclaiming that we will for sure be depopulated. We genuinely do NOT know, yet. The time has not passed yet, for us to know.
Despite not knowing, we can start worrying right now.
From other articles, we know that
- Disruptions in female periods after vaccination are permanent in some women and temporary in others, proportions unknown
- The decline in sperm quality seems to be permanent, with a minor rebound around 6 months, and that did not even consider booster doses
- Further vaccination past July or so was extremely extensive, including booster vaccination of young fertile people, possibly further damaging their fertility.
Dear readers: do you think that we are dealing with a temporary decline, or a permanent decline? Please comment and explain your opinion.
Heliobas Disciple
TB Fanatic
Put these new numbers all together, and what do they spell? D-E-P-O-P-U-L-A-T-I-O-N
Stark indications of the global toll, from Portugal and Hungary, Massachusetts, the Bahamas and Jamaica, the UK, Spain and Italy
markcrispinmiller.substack.com
Put these new numbers all together, and what do they spell? D-E-P-O-P-U-L-A-T-I-O-N
Stark indications of the global toll, from Portugal and Hungary, Massachusetts, the Bahamas and Jamaica, the UK, Spain and Italy
Mark Crispin Miller
10 hr ago
PORTUGAL
The most vaccinated country in Europe now has the worst COVID situation
June 30, 2022
https://www.activenews.ro/covid/Cea-mai-vaccinata-tara-din-Europa-are-acum-cea-mai-grava-situatie-COVID-174993
HUNGARY
Hungary: Most Vaccinated Counties Have Worst Birth Rate Drops!
Budapest is the new Taiwan -- Birth Rate Drop of -22.2%!
July 3, 2022
Interesting news on the birth rate drop front! It turns out that the most vaccinated counties of Hungary have the worst drop in birth rates in 2022! This is a within-country comparison, comparing Hungarians to Hungarians, for the same time period.
UNITED STATES
Car crash deaths explode in Massachusetts (where three cops also “died suddenly” in just ten days in April):
Massachusetts car crash deaths were at an 11-year high in 2021. 2022 is shaping up to be even worse
Jun. 23, 2022
https://www.masslive.com/news/2022/06/massachusetts-car-crash-deaths-were-at-an-11-year-high-in-2021-2022-is-shaping-up-to-be-even-worse.html
Three active-duty Massachusetts police officers die suddenly in ten days
April 20, 2022
https://fallriverreporter.com/three-active-duty-massachusetts-police-officers-die-suddenly-in-ten-days-1/
BAHAMAS
Two police officers suddenly died in the last two weeks:
Another RBPF officer died suddenly
June 30, 2022
JAMAICA
Ten Jamaican schoolteachers “died suddenly” within one month:
Another Clarendon school mourns as Jamaica loses 10 teachers in one month
June 12, 2022
Another Clarendon school mourns as Jamaica loses 10 teachers in one month
UNITED KINGDOM
Second Queen Elizabeth Hospital doctor dies after telling how 'pandemic took its toll'; Vaishnavi Kumar, 35, described as 'kind and devoted' following her death just two weeks after Andrew Haldane, 45, found dead in woodland
June 29, 2022
Second QE hospital doctor dies after saying 'pandemic took its toll'
SPAIN
Two firefighters in the same department “died suddenly” within a few days:
Commotion in the Murcia fire department due to the death of Antonio Escribano
June 30, 2022
After more than 30 years of service, 'the sparrow', as his colleagues nicknamed him, had retired just a week ago
Just a week ago, Antonio Escribano's colleagues said goodbye to this veteran firefighter on the occasion of his retirement. A new life was beginning for him after more than three decades of service. Some plans for the future that, unfortunately, have been cut short with his sudden death.
The loss of Antonio is added to the recent death, just a few days ago, of another colleague, in this case due to a long illness, which has made the fire department recognize that they feel like orphans.
Conmoción en el cuerpo de bomberos de Murcia por el fallecimiento de Antonio Escribano
ITALY
"As many as 70 sudden deaths in just fifteen days, alarming data"
June 19, 2022
“Great concern for the sudden deaths at an impressive rate. I am bewildered and indignant," says Franco Corbelli, leader of the Civil Rights Movement from Cosenza, "by the deafening silence on this terrible tragedy which unfortunately continues to have dozens of victims, children, young people and adults, men and women, who collapse, stroke despite having no health problems. Because the Government, the institutions at various levels, the media, the talk shows, continue to remain silent on the phenomenon that today represents a real, dramatic emergency, as the number of deaths shows in a disturbing way. There are hundreds, an unknown number because what we learn is only a part. Many others, in fact, are not even reported".
“In the first two weeks of June," Corbelli informs, "we learned of another seventy sudden deaths. But the number unfortunately continues to grow every day. Of these last victims, almost a dozen are in their twenties. There are footballers (and ex), aged 21, 25 and (a famous one, ex Torino) aged 39, two very young mothers of 27, a 25 year old waiter, a 29 year old girl. And yet forty-year-old doctors, pharmacists, lawyers, principals, teachers, journalists, notaries, geologists, entrepreneurs, sportsmen, workers, drivers, barbers, retirees. In the last few hours, another 37-year-old doctor, a 32-year-old young man about to get married, a 17-year-old boy, a very young 19-year-old girl, a 24-year-old girl, a recently retired former financier and a general of the carabinieri in business, in Campania, who Cosenza also operated in my city ".
“I, I repeat once again, in this year and a half, have never correctly and responsibly said anything against the vaccine, n
or advanced hypotheses or made any correlations. But in the face of the tragedy of sudden deaths and the results of numerous international scientific studies, which," Franco Corbelli underlines, "highlight, in an increasingly clear and alarming way, the possible serious cardiac risks (myocarditis and pericarditis) linked to the administration of serum, in particularly for the under 40s (although unfortunately many over 40s also continue to die), I ask that the vaccinations for all healthy people be suspended responsibly and as a precaution and that it be evaluated, for those categories considered at risk, on a case-by-case basis. . . . We can no longer continue to ignore this great tragedy”.
"Ben 70 morti improvvise in soli quindici giorni, dati allarmanti"
Heliobas Disciple
TB Fanatic
Spike S1, heparin and the coagulation cascade
Does S1 interfere with coagulation cascade? Does S1 bind to AT-III?
jessicar.substack.com
Spike S1, heparin and the coagulation cascade
Does S1 interfere with coagulation cascade? Does S1 bind to AT-III?
Jessica Rose
11 hr ago
Heparin is a naturally occurring, highly sulfated polysaccharide that plays a critical role in a range of different biological processes. Therapeutically, it is mostly commonly used as an injectable solution as an anticoagulant for a variety of indications, although it has also been employed in other forms such as coatings on various biomedical devices.1
Figure 1: Heparin. Paluck SJ, Nguyen TH, Maynard HD. Heparin-Mimicking Polymers: Synthesis and Biological Applications. Biomacromolecules. 2016 Nov 14;17(11):3417-3440. doi: 10.1021/acs.biomac.6b01147. Epub 2016 Oct 14. PMID: 27739666; PMCID: PMC5111123.
On heparin
A little about heparin(s). I was unaware of most of what I know about heparin now, up until yesterday. To the average person, I would think that heparin is a bit of an unknown. To a medical professional such as an M.D. or a nurse however, heparin is an invaluable exogenous water-soluble solution produced from pigs2 for intravenous administration to humans to resolve such coagulation pathologies as pulmonary embolism or deep vein thrombosis, for example.
Figure 2: Heparin Sodium injection for I.V. use. Heparin - Wikipedia
Heparins comprise a group of carbohydrates or saccharides that includes unfractionated heparin (UFH), low molecular weight heparin (LMWH) and synthetic heparinoids. Heparin is so-called because it was originally discovered by a medical student in the liver of a dog (from Ancient Greek ἡπατικός (hēpatikós, “of the liver”), from ἧπαρ (hêpar, “liver”3).
Heparin is an endogenous glycosaminoglycan or GAG (a polysaccharide) that comes from mast cells, and works in conjunction with anti-thrombin 3 (AT-III) (a glycoprotein) to induce anti-coagulation effects via inhibition of the coagulation cascade that, when uninhibited, results in the production of fibrin, for example. It does this by binding anti-thrombin 3 (also liver-sourced) which subsequently inhibits the coagulation cascade and thus inhibits production of fibrin. Here’s the coagulation cascade in an instructional video. I am mentioning fibrin because, well, you know.
This is one of the end points of a complex and highly regulated cascade involving many factors. So heparin is a necessary component in a tightly-regulated, highly complex system that regulates clotting. When I learned this, it made me think of the RAAS system. For those of you who haven’t seen my video or read my work on this subject, the RAAS, or the Renin Angiotensin Aldosterone System, is also a tightly-regulated highly complex closed loop system that regulates blood pressure and electrolyte levels. ACE-2 is an essential component in this system. ACE-2 is a membrane-bound (and soluble) protein necessary to induce dilation of the blood vessels following constriction, hence decreasing the blood pressure as part of the loop. ACE-2 is also the primary receptor for the spike RBD. My question remains unanswered: what effect does the presence of the spike protein have on the RAAS? I would assume that any exogenous agent able to act on a constituent of a vital system would enable, or perhaps even ensure, imbalance.
The coagulation cascade reminds me of this. Here’s why.
On heparin binding sites of proteins
The first thing that is important to know is that heparin binding sites exist in many human proteins. You can read about this in this paper: “Heparin-Binding Domains in Vascular Biology” published in 2004.4
Electrostatic interactions play a major role in the binding of heparin to proteins, and basic amino acids such as arginine and lysine are present in the heparin-binding sites of most proteins.
Interesting to me, is that they found that the proteins that bind heparin have positively-charged (at physiological pH) arginines and lysines. They also found high frequency of serines and glycines (nonbasic residues) in heparin-binding peptides. “Both have small side chains, providing minimal steric constrains and good flexibility for peptide interaction with GAG.”
Proteins with heparin binding sites bind heparin. What I want to know is, what effect does this binding have on the coagulation cascade? Is it a normal part of the system? I am still investigating the physiological roles of these proteins.
On heparin binding sites of amyloid-forming proteins
The second thing that is important to know is that of the 20,000 or so proteins of the human proteome, there are more than 25 amyloid-forming proteins that have been identified and associated with serious diseases in humans, and many of these have heparin binding sites including Aβ, α-synuclein, tau, prion and TDP-43 RRM.5 The following table shows 13 human amyloids associated with their respective diseases. For example, the human amyloid beta (Aβ) is associated with Alzheimer’s disease.
Figure 3: Table 1 - Eisenberg D, Jucker M. The amyloid state of proteins in human diseases. Cell. 2012 Mar 16;148(6):1188-203. doi: 10.1016/j.cell.2012.02.022. PMID: 22424229; PMCID: PMC3353745.
A paper published last year entitled: “SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration” suggested that the SARS-CoV-2 S1 RBD binds to a number of aggregation-prone, heparin binding proteins.6 To me, the paper is stunning and alarming. They use docking software to show high affinity binding between the RBD of the S1 portion of the spike protein and Aβ, α-synuclein, tau, prion and TDP-43 RRM.
These interactions suggest that the heparin-binding site on the S1 protein might assist the binding of amyloid proteins to the viral surface and thus could initiate aggregation of these proteins and finally leads to neurodegeneration in brain.
The authors show evidence that S1 binds to amyloid proteins with heparin binding sites, and that’s wild because as they state, this could enhance neurodegeneration. This in and of itself is frightening news and could very well implicate the spike with amyloidosis. But what I want to know is, what exactly happens physiologically when S1 binds heparin and does this binding interfere with downstream effects in the coagulation cascade? Let’s pose this as a research question:
Does the presence of exogenously-introduced endogenously-produced spike protein inhibit the coagulation cascade via S1 by a) binding AT-III or b) binding heparin and thus interfering with downstream anticoagulation effects or c) both?
If it did, we would see bleeding. Among other things.
On spike (S1)
Just to remind everyone, the spike protein of SARS-nCoV-2 comprises two parts: S1 and S2 subunits. That little section in between the S1 and S2 subunits is called a furin cleavage site and is unique to SARS-nCoV-2. It was put there and it makes the virus much more infectious.
Figure 4: Suzuki YJ, Gychka SG. SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines. Vaccines (Basel). 2021 Jan 11;9(1):36. doi: 10.3390/vaccines9010036. PMID: 33440640; PMCID: PMC7827936.
S1 protein has been found in individuals in the context of COVID-19 and post-injection with COVID-19 products.7 8 9
Figure 5: The concentration of S1 (A), spike (B), and N (C) measured in the plasma of individuals over time after diagnosis with PASC or COVID-19 following SARS-CoV-2 infection. Multiple data points may correspond to the same individual, where repeat sampling was available. Data points represent mean values ± SD (n = 2). Dashed lines indicate the LOD for each assay. Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae
Figure 6: Spike protein post 1st injection at elevated levels within the first week of injection. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241425/pdf/ciab465.pdf
So we know that S1 is around. The authors in the aforementioned paper show that the molecular docking score of S1 to heparin is very high (docking energy score: −282.57) as shown in Figure 7. This means that S1 likely binds to heparin with high affinity. An interesting question for me now becomes, since SARS-CoV-2 Spike S1 protein receptor binding domain (SARS-CoV-2 S1 RBD) binds to heparin with even higher affinity than the amyloidogenic heparin binding proteins as shown in Figure 7, what comprises the binding site? Is it arginine (Arg), lysine (Lys) serine (Ser) and glycine (Gly) rich?
According to the paper, “the docking results showed that interaction of S1 with heparin is strongly mediated by H-bonds formed by residues Asn354, Arg355, Lys 356, Asn394, Tyr396, and Arg466”. So we have 2 arginines and a lysine out of 6 residues which I suppose might qualify as arginine rich. 1/3 ain’t poor.
Figure 7: Table 2. Idrees D, Kumar V. SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. Biochem Biophys Res Commun. 2021 May 21;554:94-98. doi: 10.1016/j.bbrc.2021.03.100. Epub 2021 Mar 24. PMID: 33789211; PMCID: PMC7988450.
[continued next post]
Heliobas Disciple
TB Fanatic
[continued from post above]
On AT-III binding
AT-III is a protein secreted by the liver that binds to heparin to inhibit thrombin and subsequent coagulation cascade events. The result is bleeding. AT-III binds to a specific pentasaccharide (5 sugars) sulfation sequence contained within heparin showed in the following beautiful Pymol images.10
Figure 8: The AT: pentasaccharide complex and the allosteric effect of the AT: pentasaccharide complex. . RCSB PDB - 1AZX: ANTITHROMBIN/PENTASACCHARIDE COMPLEX
When the pentasaccharide complex binds AT-III, it induces an allosteric conformational change in the protein to purge two prolines from the inside to the outside of the structure, thus manifesting the inhibitory version of the protein which results in inhibition of the coagulation cascade (Figures 8, 9). Allostery is out of this world.
Figure 9: The allosteric activation of the inhibitory version of AT-III. Molecular Playground/Antithrombin-Heparin - Proteopedia, life in 3D
Alright so what do we know? We know that S1 binds with high affinity to heparin. We also know that the mechanism of action of the COVID-19 injectable products is delivery of coding material for the spike protein to be produced en-masse by the host cells. We also know that the lipid nanoparticles (LNPs) biodistribute heavily, and thus production of spike protein happens everywhere in the body. We know that some S1 is found circulating in people post-injection and post-COVID-19. We also know that the spike protein is cleaved at the furin-cleavage site to produce S1 and S2 portions, in the case of the viral form. Does the spike protein encoded by the mRNA contain the furin cleavage site as well?
What will be the effect, in the physiological context, of mountains of spike protein being produced and circulating post injection of COVID-19 injectable products? To me, it is easy to imagine that S1 protein would be cleaved and circulating in both post-COVID and post-injection settings. It is also easy for me to imagine that this S1 would bind endogenous heparin. It also seems highly likely, therefore, that this binding would interfere with heparin’s ability to bind AT-III which means, inhibited coagulation cascade which means: bleeding. The question remains: does S1 bind AT-III directly? Does it even need to since it likely inhibits the coagulation cascade (in any case) due to its bindability with heparin?
Figure 10: S1 binds heparin (docking energy score: −282.57) - strongly mediated by H-bonds formed by residues Asn354, Arg355, Lys 356, Asn394, Tyr396, and Arg466. Heparin binds AT-III via pentasaccharide. Does S1 bind AT-III?
I am going to leave this as an open question for now because I want to publish this article, but let me leave you with some VAERS reports reflective of a dysregulated coagulation cascade. This paper here will have some answers as well.11
Heparin-induced thrombocytopenia
One more important point. Heparin-induced thrombocytopenia is the development of thrombocytopenia (a low platelet count), due to the administration of various forms of heparin. So this happens when one has been been previously exposed to heparin and an autoimmune reaction to platelet factor IV. When platelet factor IV combines with heparin on the surface of a platelet it becomes immunogenic. The antibodies against the complex can do two things: it can tag the platelets for destruction by the spleen or it can activate the platelet. What happens then? Platelets do what platelets do!
They call more platelets over and have a platelet clot party. So what’s the end result of these two things students? Platelet loss! Which is thrombocytopenia. These clots can cause deep vein thromboses, pulmonary embolisms, myocardial infarctions, cerebrovascular accidents or cerebral venous thrombosis or acute arterial occlusions leading to limb gangrene.
It occurred to me that this might be the difference between people who bleed and people who clot. It would be very interesting to find out who of the people with thrombocytopenia had previously been administered heparin. Furthermore, shouldn’t the shots be counter-indicated in people with bleeding disorders if in fact the spike S1 protein binds to heparin?
VAERS leaves rustling…
Here are some VAERS data using MedDRA keywords like "Abnormal uterine bleeding", "Menorrhagia", "Menstrual disorder", "Menstruation irregular", "Metrorrhagia", "Heavy menstrual bleeding", "Abnormal uterine bleeding" normalized by age stratified CDC dose 1 data (the number of people who had at least 1 dose).
Figure 11: VAERS reports of abnormal bleeding and menstrual disorders as of July 1, 2022.
25-44 year olds again getting the blood end of the stick.
Here’s some VAERS data using MedDRA keywords like "Heparin", "Thrombin", "Von Willebrand", "Fibrinogen", "Plasminogen" and "Plasmin" normalized by age stratified CDC dose 1 data (the number of people who had at least 1 dose). 16 reports of heparin-related adverse events per 100,000 injections in individuals 75 years and older, is a lot of reports. Don’t forget, no URF here.
Figure 12: VAERS reports of some heparin/coagulation cascade-related AEs as of July 1, 2022.
When I looked only for “Heparin” and normalized, it became clear that there is a trend toward the elderly receiving heparin.
Figure 13: VAERS reports of only heparin AE reports as of July 1, 2022.
Deep vein thromboses are happening across all ages but primarily in individuals older than 40.
Figure 14: VAERS reports of deep vein thrombosis AE reports as of July 1, 2022.
I will be updating this article.
Heparin molecular mimicry - as a side note
There a paper entitled “Heparin-Mimicking Polymers: Synthesis and Biological Applications” published in 2016 that explores heparin-mimicking polymers and the implications and applications for biology. There are many applications for heparin mimickers including graphene-oxide doped heparin-mimetic hydrogels. The paper states that “heparin-mimicking polymers typically resist degradation/desulfation by heparinases” and this is quite scary considering that S1 is linked to heparin.
I thought it was interesting that Suramin is a molecular mimicker of heparin.
1 Paluck SJ, Nguyen TH, Maynard HD. Heparin-Mimicking Polymers: Synthesis and Biological Applications. Biomacromolecules. 2016 Nov 14;17(11):3417-3440. doi: 10.1021/acs.biomac.6b01147. Epub 2016 Oct 14. PMID: 27739666; PMCID: PMC5111123.
2 Heparin has traditionally been extracted from cattle lungs or pig intestines. Since concerns emerged over mad cow disease in the 1980s, cattle in most countries have been banned as a source of heparin. No synthetic heparin is on the market.
3 hepatic - Wiktionary
4 Muñoz EM, Linhardt RJ. Heparin-binding domains in vascular biology. Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1549-57. doi: 10.1161/01.ATV.0000137189.22999.3f. Epub 2004 Jul 1. PMID: 15231514; PMCID: PMC4114236.
5 Eisenberg D, Jucker M. The amyloid state of proteins in human diseases. Cell. 2012 Mar 16;148(6):1188-203. doi: 10.1016/j.cell.2012.02.022. PMID: 22424229; PMCID: PMC3353745.
6 Idrees D, Kumar V. SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. Biochem Biophys Res Commun. 2021 May 21;554:94-98. doi: 10.1016/j.bbrc.2021.03.100. Epub 2021 Mar 24. PMID: 33789211; PMCID: PMC7988450.
7 Zoe Swank, Yasmeen Senussi, Galit Alter, David R. Walt. Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae. medRxiv 2022.06.14.22276401; doi: Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae.
8 Letarov, A. V., Babenko, V. V., & Kulikov, E. E. (2021). Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection. Biochemistry. Biokhimiia, 86(3), 257–261. https://doi.org/10.1134/S0006297921030032.
9 Ogata AF, Cheng CA, Desjardins M, Senussi Y, Sherman AC, Powell M, Novack L, Von S, Li X, Baden LR, Walt DR. Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. Clin Infect Dis. 2022 Mar 1;74(4):715-718. doi: 10.1093/cid/ciab465. PMID: 34015087; PMCID: PMC8241425.
10 Antithrombin - Wikipedia
11 Rudd TR, Preston MD, Yates EA. The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis. Mol Biosyst. 2017;13(5):852-865. doi:10.1039/c6mb00857g.
On AT-III binding
AT-III is a protein secreted by the liver that binds to heparin to inhibit thrombin and subsequent coagulation cascade events. The result is bleeding. AT-III binds to a specific pentasaccharide (5 sugars) sulfation sequence contained within heparin showed in the following beautiful Pymol images.10
Figure 8: The AT: pentasaccharide complex and the allosteric effect of the AT: pentasaccharide complex. . RCSB PDB - 1AZX: ANTITHROMBIN/PENTASACCHARIDE COMPLEX
When the pentasaccharide complex binds AT-III, it induces an allosteric conformational change in the protein to purge two prolines from the inside to the outside of the structure, thus manifesting the inhibitory version of the protein which results in inhibition of the coagulation cascade (Figures 8, 9). Allostery is out of this world.
Figure 9: The allosteric activation of the inhibitory version of AT-III. Molecular Playground/Antithrombin-Heparin - Proteopedia, life in 3D
Alright so what do we know? We know that S1 binds with high affinity to heparin. We also know that the mechanism of action of the COVID-19 injectable products is delivery of coding material for the spike protein to be produced en-masse by the host cells. We also know that the lipid nanoparticles (LNPs) biodistribute heavily, and thus production of spike protein happens everywhere in the body. We know that some S1 is found circulating in people post-injection and post-COVID-19. We also know that the spike protein is cleaved at the furin-cleavage site to produce S1 and S2 portions, in the case of the viral form. Does the spike protein encoded by the mRNA contain the furin cleavage site as well?
What will be the effect, in the physiological context, of mountains of spike protein being produced and circulating post injection of COVID-19 injectable products? To me, it is easy to imagine that S1 protein would be cleaved and circulating in both post-COVID and post-injection settings. It is also easy for me to imagine that this S1 would bind endogenous heparin. It also seems highly likely, therefore, that this binding would interfere with heparin’s ability to bind AT-III which means, inhibited coagulation cascade which means: bleeding. The question remains: does S1 bind AT-III directly? Does it even need to since it likely inhibits the coagulation cascade (in any case) due to its bindability with heparin?
Figure 10: S1 binds heparin (docking energy score: −282.57) - strongly mediated by H-bonds formed by residues Asn354, Arg355, Lys 356, Asn394, Tyr396, and Arg466. Heparin binds AT-III via pentasaccharide. Does S1 bind AT-III?
I am going to leave this as an open question for now because I want to publish this article, but let me leave you with some VAERS reports reflective of a dysregulated coagulation cascade. This paper here will have some answers as well.11
Heparin-induced thrombocytopenia
One more important point. Heparin-induced thrombocytopenia is the development of thrombocytopenia (a low platelet count), due to the administration of various forms of heparin. So this happens when one has been been previously exposed to heparin and an autoimmune reaction to platelet factor IV. When platelet factor IV combines with heparin on the surface of a platelet it becomes immunogenic. The antibodies against the complex can do two things: it can tag the platelets for destruction by the spleen or it can activate the platelet. What happens then? Platelets do what platelets do!
They call more platelets over and have a platelet clot party. So what’s the end result of these two things students? Platelet loss! Which is thrombocytopenia. These clots can cause deep vein thromboses, pulmonary embolisms, myocardial infarctions, cerebrovascular accidents or cerebral venous thrombosis or acute arterial occlusions leading to limb gangrene.
It occurred to me that this might be the difference between people who bleed and people who clot. It would be very interesting to find out who of the people with thrombocytopenia had previously been administered heparin. Furthermore, shouldn’t the shots be counter-indicated in people with bleeding disorders if in fact the spike S1 protein binds to heparin?
VAERS leaves rustling…
Here are some VAERS data using MedDRA keywords like "Abnormal uterine bleeding", "Menorrhagia", "Menstrual disorder", "Menstruation irregular", "Metrorrhagia", "Heavy menstrual bleeding", "Abnormal uterine bleeding" normalized by age stratified CDC dose 1 data (the number of people who had at least 1 dose).
Figure 11: VAERS reports of abnormal bleeding and menstrual disorders as of July 1, 2022.
25-44 year olds again getting the blood end of the stick.
Here’s some VAERS data using MedDRA keywords like "Heparin", "Thrombin", "Von Willebrand", "Fibrinogen", "Plasminogen" and "Plasmin" normalized by age stratified CDC dose 1 data (the number of people who had at least 1 dose). 16 reports of heparin-related adverse events per 100,000 injections in individuals 75 years and older, is a lot of reports. Don’t forget, no URF here.
Figure 12: VAERS reports of some heparin/coagulation cascade-related AEs as of July 1, 2022.
When I looked only for “Heparin” and normalized, it became clear that there is a trend toward the elderly receiving heparin.
Figure 13: VAERS reports of only heparin AE reports as of July 1, 2022.
Deep vein thromboses are happening across all ages but primarily in individuals older than 40.
Figure 14: VAERS reports of deep vein thrombosis AE reports as of July 1, 2022.
I will be updating this article.
Heparin molecular mimicry - as a side note
There a paper entitled “Heparin-Mimicking Polymers: Synthesis and Biological Applications” published in 2016 that explores heparin-mimicking polymers and the implications and applications for biology. There are many applications for heparin mimickers including graphene-oxide doped heparin-mimetic hydrogels. The paper states that “heparin-mimicking polymers typically resist degradation/desulfation by heparinases” and this is quite scary considering that S1 is linked to heparin.
I thought it was interesting that Suramin is a molecular mimicker of heparin.
1 Paluck SJ, Nguyen TH, Maynard HD. Heparin-Mimicking Polymers: Synthesis and Biological Applications. Biomacromolecules. 2016 Nov 14;17(11):3417-3440. doi: 10.1021/acs.biomac.6b01147. Epub 2016 Oct 14. PMID: 27739666; PMCID: PMC5111123.
2 Heparin has traditionally been extracted from cattle lungs or pig intestines. Since concerns emerged over mad cow disease in the 1980s, cattle in most countries have been banned as a source of heparin. No synthetic heparin is on the market.
3 hepatic - Wiktionary
4 Muñoz EM, Linhardt RJ. Heparin-binding domains in vascular biology. Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1549-57. doi: 10.1161/01.ATV.0000137189.22999.3f. Epub 2004 Jul 1. PMID: 15231514; PMCID: PMC4114236.
5 Eisenberg D, Jucker M. The amyloid state of proteins in human diseases. Cell. 2012 Mar 16;148(6):1188-203. doi: 10.1016/j.cell.2012.02.022. PMID: 22424229; PMCID: PMC3353745.
6 Idrees D, Kumar V. SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. Biochem Biophys Res Commun. 2021 May 21;554:94-98. doi: 10.1016/j.bbrc.2021.03.100. Epub 2021 Mar 24. PMID: 33789211; PMCID: PMC7988450.
7 Zoe Swank, Yasmeen Senussi, Galit Alter, David R. Walt. Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae. medRxiv 2022.06.14.22276401; doi: Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae.
8 Letarov, A. V., Babenko, V. V., & Kulikov, E. E. (2021). Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection. Biochemistry. Biokhimiia, 86(3), 257–261. https://doi.org/10.1134/S0006297921030032.
9 Ogata AF, Cheng CA, Desjardins M, Senussi Y, Sherman AC, Powell M, Novack L, Von S, Li X, Baden LR, Walt DR. Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. Clin Infect Dis. 2022 Mar 1;74(4):715-718. doi: 10.1093/cid/ciab465. PMID: 34015087; PMCID: PMC8241425.
10 Antithrombin - Wikipedia
11 Rudd TR, Preston MD, Yates EA. The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis. Mol Biosyst. 2017;13(5):852-865. doi:10.1039/c6mb00857g.
Heliobas Disciple
TB Fanatic
is pfizer suppressing vaccine adverse events reports in infants?
because it would certainly fit as part of a larger pattern
boriquagato.substack.com
is pfizer suppressing vaccine adverse events reports in infants?
because it would certainly fit as part of a larger pattern
el gato malo
15 hr ago
the legacy US press has become a sad and captured thing that desperately cheer leads for such advertisers as remain to fund the melting iceberg of its former glory as it drifts off into irrelevance.
but this is not so in some of the rest of the world and this is why reading foreign news is often the best way to learn what’s actually happening in america. this goes double for foreign policy and squintuplety-zillion (possibly not a real number) times for anything touching pharma because pharma advertising is the backbone of american media and you criticize the golden goose at your bottom line’s existential peril.
and this takes us to israel whose press has been quite a lot freer and franker than our own on issues of covid vaccines.
read the whole article, it’s terrifying. (and has some great data tables)
it describes a case of cardiac arrest in a previously healthy 2 month old male approx 1 hour after vaccination.
“Patient administered vaccination, observed for 15 minutes left the clinic then returned one hour later on 02 Feb 2021, presenting as skin cold, clammy and with chest pain, cardiac arrest event then developed, patient stabilised and transferred for further medical treatment… The outcome of the events was unknown. This case was reported as serious with seriousness criteria-life threatening from HA. No follow-up attempts possible. No further information expected".
Unsure if patient was enrolled in clinical trial”. However, the author of the report also states that the report was ”received from a contactable Other Health Care Professional by Pfizer from the Regulatory Agency”. This note implies that the infant might have actually participated in Pfizer's trial. The regulatory agency report Safety Report Unique Identifier GB-MHRA-ADR 24687611 - indicates that the report came from Great Britain (the first 2 letters in the report ID stand for the country of origin, GB- Great Britain, and MHRA indicate that the source of reporting was its' drug authority).
so, what exactly happened with this child?
- there is no other legal means to have dosed the child. if this were not in a trial, it would have been contra indicated, immoral, and likely illegal.
- the report appears to be from a pfizer associated HCP
and how did the child do? did they recover? we have no idea.
“No follow-up attempts possible. No further information expected."
what on earth is that? i flat out cannot imagine any even half reasonable explanation to drop this child from follow up apart from the sinister one: that they did not want to know and so they are memory holing a baby who had a heart attack from their product.
this is already deeply worrying and indicative of possible manipulation and fraud.
but it gets MUCH worse.
there was not a single life threatening event recorded in the entire pediatric trial. not one.
there was only one “related” severe event (out of 5 serious events, 4 of which were deemed “unrelated”)
(SOURCE)
so, if this child was in the trial we’re already getting into some serious questions:
this sure looks to me like it ought to have been classified as life threatening. it’s cardiac arrest in a 2 month old.
but even if we’re going to call it “severe” instead, then this was it. the only related one in the whole trial.
and THAT is where we start to run into serious problems.
because this child was not an isolated case.
there were 58 of these. (and VAERS likely under-reports by 10-100X)
The analysis shows there were at least 58 cases of severe and life-threatening adverse reactions among babies and toddlers 3 years old and younger. This finding is especially puzzling considering the fact that they weren’t supposed to be vaccinated at this age to begin with. Sadly, similarly to the case reported above, most VAERS reports do not indicate how and under which circumstances they were exposed to the vaccine – were they participants in the companies' trials? And if not, why and in which circumstances were they vaccinated?
and if even one of these life threatening events was actually in the trial, we need to be asking some serious questions about fraud.
and it keeps getting worse.
many children in the VAERS reporting had massive responses with multiple effects.
and then they seem to have had no or conflicting follow up.
and they seem to be nowhere in the trial results.
these numbers are terrifying and if all were in the trial would imply an over 1% life threatening AE rate. that’s easily 100X the risk of covid to this group, probably more like 1,000 or even 10,000X.
this is not subtle stuff. this is incredibly severe and systemic reaction. and the data is an obvious mess with children being described both as “not having recovered” but also “not having died” and disappearing like peter pan’s playmates.
this is screaming for investigation.
either many doctors all over the world are badly injuring babies by experimentally jabbing them with unapproved product (and i doubt this as lawsuits would be rife) or this was all part of the pfizer trial and they suppressed it.
place your bets.
pfizer have been playing outlandish games with their vaccine trials.
and the pediatric trial looks little different. their headline efficacy figures were the same bad methodology used to hide immune suppression all along. their headline result ignored a staggering 97% of cases in the trial by only counting from dose 3 + 7 days. real VE was 23%, not 80% and missed stat sig entirely in under 2’s.
they buried it in a supplement.
these are the sort of people we’re being asked to trust.
and the further one goes back into pfizer history, the less trustworthy they look. CEO albert bourla has a past so dark that if he applied for a position as a demon, asmodeus would probably pass him over out of fear of losing his job once alberto got settled in.
as so consistently seems to be the modal outcome, regulators were either asleep or captured.
pfizer is just about if not the most fined and sued pharma company in the world for a reason and the reason is “their behavior.”
their cattle vaccine (PregSure BVD) was causing massive, wholesale death in calves that nursed from mothers that got jabbed. the inoculant was given over and over as regular doses. the problems emerged, the data was clear, and pfizer fought it all.
they lied and denied and most of all kept selling and marketing the vaccine.
they claimed the side effects were overstated and unlinked.
calves were literally bleeding out through their eyes and ears and having “blood sweats.” it destroyed their bone marrow.
it was killing 15% of the junior moo team at some farms. this was not “long ago.” this was 2006. no one pulled it until 2010.
despite it being well studied and established, my understanding is that pfizer denies the issues to this day.
the head of the animal division that did this was albert bourla.
albert is currently the CEO of pfizer.
they not only failed to fire him over this, they promoted him.
draw your own conclusions about their priorities from that…
big pharma is not like other pharma. i love small pharma. i know 100’s of wonderful people there, clever researchers and good eggs who are really, truly trying to figure things out and make good products.
but big pharma is not mostly development. they buy that. they are mostly marketing and sales and the best way to do that is regulatory capture and market domination. they play on a much bigger scale and those are they kinds of stakes that bring out the worst in people. those are the kind of stakes where you cannot admit you were wrong and it’s better to lie and keep killing people than allow mistakes to be known.
and this is far from isolated and far from new.
when you spend this kind of capital, both monetary and reputational, the gloves are off. you play dirty. you play to win. big pharma has a practices list that make big tobacco look like your neighborhood farm to table co-op.
it has ALWAYS been like this.
one of the things that’s been so surreally bizarre to me throughout all this branch covidian cultism is the radical society scale amnesia and inversion here.
3 years ago, everyone knew big pharma were nasty, self-serving, dishonest, rapacious entities. this was triple true on the left. and now they are the darlings and the saviors, they who must be trusted, they to whom we must defer. cuz, science.
this is like watching baby mice demanding to be babysat by malayan pit vipers.
it has to rank among the greatest marketing campaigns in human history.
they have not only rehabilitated their deservedly tarnished reputations but burnished them to a gleaming shine.
warp speed warped minds.
mordred has become sir gallahad.
we have forgotten who they are.
there is simply far too much smoke here to be no fire and i suspect that uncovering adverse event suppression is how this whole tawdry mess unravels.
people can forgive a failure to be effective. lots of drugs that barely or don’t work still sell well.
but they will not forgive being attacked, and that’s what suppressing reports of harms and side effects does.
they will especially not forgive an attack on their children.
and it’s failing. uptake is incredibly low, parents deeply suspect. skepticism is high and rising. and a real fight is brewing.
this was the bridge too far and with efficacy collapsed and outright inverted on infection, harms soaring and likely worse for boosters than originals, and the FDA doing nothing but tearing out all the safeguards and trying to make these jabs evergreen without clinical trials (like flu shots) it’s just getting too big to hide.
this will all come apart, collapsed under its own dead weight and declaring “fraud” will likely invalidate the EUA liability shields.
the world is going to turn on pfizer because it will be the low energy path and a way for the politicians who pushed this to play the victim and divert your anger.
europe is already waking up and post election, i suspect the US dominoes will start to fall as well.
“who knew what and when did they know it?” is going to become the name of the game.
the next 6-12 months are going to get pretty wild.
.
Heliobas Disciple
TB Fanatic
A Perpetual Pandemic is On the Way Thanks to Planned New COVID-19 Vaccines and FDA's Insanity
FDA will allow Moderna & Pfizer to update the variants targeted by their mRNA injections and require no new studies. What's even more insane? Their "updates" will ensure a Perpetual Pandemic.
popularrationalism.substack.com
A Perpetual Pandemic is On the Way Thanks to Planned New COVID-19 Vaccines and FDA's Insanity
FDA will allow Moderna & Pfizer to update the variants targeted by their mRNA injections and require no new studies. What's even more insane? Their "updates" will ensure a Perpetual Pandemic.
James Lyons-Weiler
Jul 1
Did you know that in their insane new framework, US FDA will allow them to change variants w/no new science?
Also - the new vaccines will include mRNA encoding the original, extinct Wuhan-1 spike protein - ensuring a forever pandemic.
I interviewed Toby Rogers this week for “America Out Loud Pulse” to help him share information on the FDA’s new framework for SARS-CoV-2 strain composition of COVID-19 vaccines. Of all of the outcomes of that meeting, Moderna and Pfizer are being told by our idiotic FDA they update the strain composition to include Omicron, but also that the FDA will
“Recommend that all vaccines used for both primary series and booster doses retain current composition (i.e., Wuhan Spike based)”. (FDA Briefing Document, link below).
Due to antibody-dependent enhancement (ADE), this will guarantee the continued spread of COVID-19 by the vaccinated.
Importantly, ADE was only studied in animals using vaccine-induced Wuhan-1 spike antibodies and Wuhan-1 viral challenge. Those studies used the wrong animals (Rhesus macaques instead of ferrets), were very small, and Pfizer removed one animal as an “outlier”.
There has not been - because FDA failed to require - any study of ADE caused by Wuhan-1 antibodies from vaccines and challenged by any of the new variants.
And there will not be - because FDA will not NOW require, given their newly adopted “Framework” - which dramatically lowers the regulator bar to “No Science Necessary” - any study of ADE caused by Wuhan-1 antibodies from these new vaccines.
This will ensure the perpetual spread of SARS-CoV-2. All we have to do to understand what Dr. Fantini and his team found to see this is necessarily so:
Fantini made specific claims on a timeline of ADE based on highly accurate molecular modeling that I find most impressive and that I think adds immensely to how solid the knowledge base on ADE. He and his teams’ findings were:
- Wuhan-1 Ab vs. Wuhan-1 : No ADE
- Wuhan-1 Ab vs. Alpha : No ADE
- Wuhan-1 Ab vs. Beta : ADE, but no vaccine at the time
- Wuhan-1 Ab vs. Gamma : ADE, but no vaccine at the time
- Wuhan-1 Ab vs. Delta + all the rest : ADE and Vaccine-induced ADE
Welcome to Perpetual Pandemic.
My interview with Toby will appear next week on America Out Loud Pulse.
FDA’s Briefing Document
SARS-CoV-2 strain composition of COVID-19 vaccines