If you tend to have hot, dry summers, remove all but the top cluster (Or top two clusters) of leaves, and bury the stem (leaving just enough length so the leaves aren't touching the soil) straight up and down.
If your weather tends to be on the cooler side, remove the extra leaf clusters as above, but bury the stem in a horizontal trench. Either way, the plant will put out roots along the whole length of stem.
Mulching with RED mulch (in cooler areas, use red plastic) increases yields in tomatoes.
But *don't* add lots of extra nitrogen, in the form of fertilizer or manure. You end up with large, lush, green plants, but often few blossoms or fruit. The exception is if your season is very long... production will be delayed and late, but you may get huge yields. However, that lush foliage tends to be more prone to insect damage and disease.
Caging has been the most practical way for us to support large plants (I grow almost all indeterminate heirlooms, and they can get BIG) , keep foliage and fruit mostly off the ground, and allow us to pick the highest percentage of blemish free fruit.
Removing suckers can help in letting sunlight into the interior of the plant, allow more airflow, speeding ripening and helping slow the spread of diseases, but it's never been time efficient for us.
Deep watering, providing approximately 1-2 inches per week (higher amounts in hot, dry weather) is best. Overwateting, or simply a wet year will cause fruit to crack just before fully ripe. Cherry tomatoes are the worst... thick skinned paste types the most resistant. Some varieties say they are especially crack resistant.. if you live in a wet climate, plant those!
And if late blight has EVER been a problem in your area, start spraying with antifungal sprays early, and spray as directed for the entire season! Nothing sucks like having 200, 6' tall, lush tomato plants loaded with green and just-starting-to-ripen fruit, and watch them die completely of late blight within a week.
We use a copper based spray, and while it won't do much if used after symptoms appear, it works very well as preventing infection.
Above all, pray! LOL!
Summerthyme