HEALTH New ‘exercise pill’ could replace physical benefits of working out: study

jward

jward

passin' thru

New ‘exercise pill’ could replace physical benefits of working out: study​


Tired of working out? There may soon be a pill for that.

A new “exercise pill” could potentially replace some — not all — of the benefits of working out, according to a new study.
Scientists from the Washington University School of Medicine in St. Louis spent 10 years creating new compounds that seem to be able to mimic the physical benefits of a workout — at least in rodent cells — that could become ingredients for a future supplement.

Athletic man with a naked torso holding pills in his hand. Vitamins and doping. Healthy lifestyle and diet. Medicine Concept
The findings could result in a new way to treat muscle atrophy and other medical conditions.

The team of researchers, who presented their findings at the spring meeting of the American Chemical Society (ACS), hope to replicate the physical effects of exercise, specifically the ability to enhance metabolism and growth, as well as improved muscle performance.

“We cannot replace exercise; exercise is important on all levels,” Bahaa Elgendy, a professor of anesthesiology and the project’s principal investigator, said in a media release. “If I can exercise, I should go ahead and get the physical activity. But there are so many cases in which a substitute is needed.”

However, the findings could result in a new way to treat muscle atrophy and other medical conditions, including heart failure and neurodegenerative disease.

If the drug could mimic the physical effects of exercise, it could help offset the weakness in a person’s muscles that occur naturally as people age or for those affected by cancer, certain genetic conditions or any other reason a person may be unable to do regular physical activity.

Elgendy added that the “exercise pill” could potentially counter the loss of both muscle and fat caused by other drugs, such as new weight-loss medications.

When the scientists tested on mice, they found that the compound increased a fatigue-resistant muscle fiber, which in turn improved the rodents’ endurance when running on a treadmill.

But more testing needs to be done before the pill can be available for human use. The scientists will be testing the compound in other animals as the next step in the research process.

nypost.com

New ‘exercise pill’ could replace physical benefits of working out: study

The findings could result in a new way to treat muscle atrophy and other medical conditions, including heart failure and neurodegenerative disease.
nypost.com nypost.com
 
colonel holman

colonel holman

Veteran Member
As a PT, this doesn’t sound right… HOWEVER… this may have some link to a very new discovery in PT for quickly restoring muscle strength, stamina and bulk. BFR: Blood Flow Restriction, whereby the therapists applies tourniquet an extremity to shut down blood flow while patient does strengthening exercise to the point of failure. It doesn’t take long, seconds to a minute, very few reps with a moderate to heavy load. Patients end up with very rapid recovery of strength, stamina and bulk from a seemingly minor amount of exercise.

The thought is there are chemical changes brought on by ischemia (loss of blood supply) during loading that stimulates accelerated recovery. Likely mediated by hormone release, localized ischemic enzyme production, generalized systemic ischemic enzymes. There have even been findings of positive responses in the opposite extremity (not the one choked off or loaded) as if it too had undergone that treatment, indicating systemic biochemical activity. Perhaps a pill may provide some of that ???

After 50 yrs in health care, I have seen some amazing advances (versus some amazing mistakes, as well as some amazing snake oil).
 
L

Luddite

Veteran Member
I'll take actual exertion.

I split out 30 locust posts with wedges and a splitting hammer Saturday.

That's after cutting and splitting a load of firewood. I was close enough to the road to wave at many cars and atvs as they went by. Most probably thought I was crazy. You can buy posts for 5 or 6 dollars a piece.

With every sweat drop I gave thanks for the ability to do that at my age with few pains. The cramps and pain came the next day. :)

I hope the drugs help those people afflicted with ailments preventing actual exercise or manual labor.

I hope every doctor that might prescribe it to an able bodied person loses his/her medical license. Jmo
 
Melodi

Melodi

Disaster Cat
Like most technology and many pharma products, this pill could be a potential lifesaver for certain people. If the side effects are limited, it does as it is reported to do. Sure, people in wheelchairs, people with brittle bone syndrome, people with advanced heart disease, or people with any genuine issue that makes them medically unable to work out enough to get in shape or who can't exercise enough to accomplish this on their own.

But that is different from how this will be marketed and sold. Like the variations of Ozempec that were used for years to treat Diabetics, it may start out being limited to those with severe health and mobility issues. But the moment it was realized how much weight diabetics who used it were losing, all hell broke loose.

Suddenly, instead of being marketed as "Your Once weak Insulin-like injection," it was a "Miracle weight loss drug! Get it now and be Thin!" Soon, diabetics who had taken it for half a decade couldn't get their prescriptions filed and were forced to wean off the drug suddenly (known to have its dangers) and go back on old-fashioned insulin or metaphorman.

It pitted people with severe illnesses against desperate people with a different dangerous medical ailment—extreme obesity—against each other. Sadly, this became a new version of the "Deserving and Undeserving" poor arguments from the late 19th century. The misery increased when social "influencers" and famous people started using it to wear Marilyn Monroe's Dress or similar public stunts.

This drug will almost certainly cause the same chaos, at least at first, even if it is initially restricted to trials and usage by the disabled and bedridden who might benefit from it. But as soon as it is declared "safe," the headlines will start just as they did with Ozempec: "My new body!" or "Do Nothing and Look like Superman without Steriods!"And yes, "Doctors believe it may counter the effects of Ozempic. Ask your doctor about "Insta Body" today and see if it is right for you!"

Mother Nature doesn't seem to mind serious attempts to ease pain and suffering; though sometimes there are still unexpected and nasty surprises. Thalidomide comes to mind. But creating something and then mass marketing something designed to appeal to people just to be lazy or not do something distasteful because they don't want to; nope, Mother Nature doesn't like that.
 
B

Barry Natchitoches

Has No Life - Lives on TB
colonel holman said:
As a PT, this doesn’t sound right… HOWEVER… this may have some link to a very new discovery in PT for quickly restoring muscle strength, stamina and bulk. BFR: Blood Flow Restriction, whereby the therapists applies tourniquet an extremity to shut down blood flow while patient does strengthening exercise to the point of failure. It doesn’t take long, seconds to a minute, very few reps with a moderate to heavy load. Patients end up with very rapid recovery of strength, stamina and bulk from a seemingly minor amount of exercise.

The thought is there are chemical changes brought on by ischemia (loss of blood supply) during loading that stimulates accelerated recovery. Likely mediated by hormone release, localized ischemic enzyme production, generalized systemic ischemic enzymes. There have even been findings of positive responses in the opposite extremity (not the one choked off or loaded) as if it too had undergone that treatment, indicating systemic biochemical activity. Perhaps a pill may provide some of that ???

After 50 yrs in health care, I have seen some amazing advances (versus some amazing mistakes, as well as some amazing snake oil).
Click to expand...
Is that procedure something medicare would pay for, Colonel?

I have heard good things about this procedure, and I lost so much fitness because of several years of bone on bone arthritis in both of my knees. I am workinghard, but I cannot seem to get the level of fitness back that I need. Especially with a wife with cancer, who I might need to pick up off the floor some time in the future.
 
Lone_Hawk

Lone_Hawk

Resident Spook
Sacajawea said:
I see there was no mention of potential side effects - either immediate or long term.
Click to expand...

Wyominglarry said:
In another week it will be proven to be fatal to take for more than one month. How many drugs have been approved by our corrupt FDA only to get pulled from the market after one year due to all the deaths and other advise effects?
Click to expand...

Death is a feature with all new drugs, not an issue.
 
colonel holman

colonel holman

Veteran Member
Barry Natchitoches said:
Is that procedure something medicare would pay for, Colonel?

I have heard good things about this procedure, and I lost so much fitness because of several years of bone on bone arthritis in both of my knees. I am workinghard, but I cannot seem to get the level of fitness back that I need. Especially with a wife with cancer, who I might need to pick up off the floor some time in the future.
Click to expand...
It would be covered as “therapeutic exercise” or “neuromuscular re-education” during PT sessions. But make sure you find a PT trained in “blood flow restriction”. Lots are, but many are not, yet
 
N

night driver

ESFP adrift in INTJ sea
Larry, that widespread prescribing for a year+ is just Phase VII testing.

It's like Computers and Decision Support Design.
I can create a data stream that tests ALL of the decision matrices, and I can beat the system for a month. The VERY DAY I release the system to live processes, it's going to come down because it will have been (attacked) used by orangutans.
 
D

Dr. G

Senior Member
Hey, increase of lean tissue, fat loss or less fat acculmation, increase protein synthesis, modulation of mTor,....gee let me think...anabolic steroids.
Oh ya want something more organic/natural...Testosterone and other hormones.
Any of them properly dosed for age, sex, condition, and tolerance can almost work miracles.
 
subnet

subnet

Boot
Wyominglarry said:
In another week it will be proven to be fatal to take for more than one month. How many drugs have been approved by our corrupt FDA only to get pulled from the market after one year due to all the deaths and other advise effects?
Click to expand...
Not enough of them...cough.. cough ..clot shot
 
PghPanther

PghPanther

Has No Life - Lives on TB
Building lean muscle mass without physical resistance training to stimulate that?

Has to involved some nitrogen molecule process that forces branch chained amino acids into hyper assimilation with the muscle cells.........and that whole process as a host of problems with side effects.

And a pill?...........that means you liver and kidneys will get hammered.....................if there is no injectional form of it.

Plus its only temporary...........you'd have to keep doing it with diminishing returns while increasing the side effects.

Just ask anyone who does anabolic cycles for steroids, growth hormones and/or insulin loading.

Look if there is something to make you look in shape or increase muscle size the pro bodybuilders will find it out and use it first.........and as it is those people are dropping over dead earlier than even pro wrestlers because their health is so compromised from such supplementation.
 
pauldingbabe

pauldingbabe

The Great Cat
jward said:
My thought is a cynical "sure. and it feels like love and taste like chocolate, right?!! :: eye roll ::"

but maybe there is some way to increase the oxygen carrying capacity of a muscle to help relieve some of the problems, I dunno.
Click to expand...


You can! Naturally too...

Horny Goat Weed (Epimedium genus) aids the O2/ CO2 exchange.

I've taken it with Rhodiola Rose when taking on a task that I need a bit more endurance.

There all better...

;)
 
saeurs

saeurs

Contributing Member
The only way to get exercise involuntarily is to cause whole-body seizures. So, they are giving everyone who takes this epilepsy?

Better living through chemistry!!
 
Cacheman

Cacheman

Ultra MAGA!
I can see it now on the label,

WARNING: May cause high blood pressure, irritable bowel syndrome, short temper, short bouts of hyperactivity, increased bouts of sudden fatigue, anal leakage, thoughts of suicide and an increased urge to gamble.

They have to put out something to replace physical exertion given that so many people who drank their covid tea seem to drop dead at the slightest bit of elevated heart rate.
 
F

FireDance

TB Fanatic
I would love to see this work on muscle wasting for wheelchair or bedbound people. However, the side effects could be huge. Personally, I would stay away.

@BARRY (and all of us who are caretakers) - remember, if you have someone fall in the home, you can call EMS for a lift assist. Better than hurting yourself lifting someone who will generally be almost dead weight. Plus, they will check that person out and make sure they have not been hurt in the fall. Have zero idea what wait times may be these days, but if you call the non-emergency number, I’m sure they can give you more information. It doesn’t take much to hurt someone besides yourself after a fall. Best to have help.
 
Southside

Southside

Has No Life - Lives on TB
There's a pill for that.
They ALL have side effects. As does exercise. Difference is, the side effects of exercise are mostly good.
 
West

West

Senior
Cacheman said:
I can see it now on the label,

WARNING: May cause high blood pressure, irritable bowel syndrome, short temper, short bouts of hyperactivity, increased bouts of sudden fatigue, anal leakage, thoughts of suicide and an increased urge to gamble.

They have to put out something to replace physical exertion given that so many people who drank their covid tea seem to drop dead at the slightest bit of elevated heart rate.
Click to expand...
Don't forget about a vary possible tear in your perineum!

Had to look that up, there's some drug they advertised all the time on TV. and I'm saying....WTF would any one take that chance?
 
hiwall

hiwall

Has No Life - Lives on TB
Will they give the drug to cows and other meat animals to make them grow faster and put on more muscle mass?
 
SmithJ

SmithJ

Veteran Member
lol

Headline: New ‘exercise pill’ could replace physical benefits of working out: study

Story: “We cannot replace exercise; exercise is important on all levels,” Bahaa Elgendy, a professor of anesthesiology and the project’s principal investigator, said in a media release.
 
You must log in or register to reply here.
Top