http://www.washingtonpost.com/wp-dyn/content/article/2005/07/18/AR2005071800938.html
WASHINGTON -- Changes in the avian flu virus have made it less deadly to ducks, potentially turning them into medical Trojan horses where the flu can hide while continuing to infect other birds and humans.
Waterfowl such as ducks have been natural hosts of this type of influenza before but rarely became ill from it until 2002, when an evolving strain killed of a large number of the birds.
Since then, however, the virus has continued to change, reverting to a form less dangerous to ducks but still able to cause illness and death in chickens and humans, according to a study in Tuesday's issue of Proceedings of the National Academy of Sciences.
"These results suggest that the duck has become the Trojan horse of Asian H5N1 influenza viruses," reported a research team led by Robert G. Webster of St. Jude Children's Research Hospital in Memphis, Tenn.
"The ducks that are unaffected by these viruses continue to circulate these viruses, presenting a pandemic threat," the team said.
The researchers infected domestic ducks with flu isolated at various times.
They found that ducks infected with H5N1 from 2003 or 2004 were contagious for 11-17 days, a longer transmission time than pre-2002 strains. The researchers also noted that the virus was transmitted primarily through the upper respiratory tract instead of through fecal matter as in older strains.
When flu virus from ducks that had survived the disease was administered to healthy animals, it no longer caused disease in ducks, but still caused disease in chickens.
Over the last two years, hundreds of millions of birds, including poultry and wild birds, have died or were slaughtered across Asia because of the H5N1 bird flu virus, which has also infected some humans, killing 51 people in Vietnam, Thailand and Cambodia.
The humans appear to have been infected by contact with birds. Experts fear that if the virus mutates into a form that could be passed easily from person to person it could spark a global pandemic, killing millions.
Webster's research was funded by the U.S. Public Health Service and American Lebanese Syrian Associated Charities.
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On the Net:
Proceedings of the National Academy of Sciences: http://www.pnas.org
St. Jude Children's Research Hospital: http://www.stjude.org
WASHINGTON -- Changes in the avian flu virus have made it less deadly to ducks, potentially turning them into medical Trojan horses where the flu can hide while continuing to infect other birds and humans.
Waterfowl such as ducks have been natural hosts of this type of influenza before but rarely became ill from it until 2002, when an evolving strain killed of a large number of the birds.
Since then, however, the virus has continued to change, reverting to a form less dangerous to ducks but still able to cause illness and death in chickens and humans, according to a study in Tuesday's issue of Proceedings of the National Academy of Sciences.
"These results suggest that the duck has become the Trojan horse of Asian H5N1 influenza viruses," reported a research team led by Robert G. Webster of St. Jude Children's Research Hospital in Memphis, Tenn.
"The ducks that are unaffected by these viruses continue to circulate these viruses, presenting a pandemic threat," the team said.
The researchers infected domestic ducks with flu isolated at various times.
They found that ducks infected with H5N1 from 2003 or 2004 were contagious for 11-17 days, a longer transmission time than pre-2002 strains. The researchers also noted that the virus was transmitted primarily through the upper respiratory tract instead of through fecal matter as in older strains.
When flu virus from ducks that had survived the disease was administered to healthy animals, it no longer caused disease in ducks, but still caused disease in chickens.
Over the last two years, hundreds of millions of birds, including poultry and wild birds, have died or were slaughtered across Asia because of the H5N1 bird flu virus, which has also infected some humans, killing 51 people in Vietnam, Thailand and Cambodia.
The humans appear to have been infected by contact with birds. Experts fear that if the virus mutates into a form that could be passed easily from person to person it could spark a global pandemic, killing millions.
Webster's research was funded by the U.S. Public Health Service and American Lebanese Syrian Associated Charities.
___
On the Net:
Proceedings of the National Academy of Sciences: http://www.pnas.org
St. Jude Children's Research Hospital: http://www.stjude.org