Tristan
Has No Life - Lives on TB
Of course it's Kabuki.
As designed.
"Cleaner" may not be a official job title in Gobt., but they have plenty of them working the problem.
And I'm not talking Custodial Services.
Last edited:
CORONA Main Coronavirus thread
- Thread starter Heliobas Disciple
- Start date
-
- Tags
- coronavirus
Of course it's Kabuki.
As designed.
"Cleaner" may not be a official job title in Gobt., but they have plenty of them working the problem.
And I'm not talking Custodial Services.
Tristan
Has No Life - Lives on TB
BTW, that vid is worth an off-line 'Save'.
Critical info has been disappearing from the internet.
Profit of Doom
Dismember
Conspiracy theorists like Ed Dowd?
Heliobas Disciple
TB Fanatic
New RNA vaccines coming
Dr. John Campbell
May 6, 2024
11 min
Bill Gates in on the case
jward
passin' thru
Mario Nawfal
@MarioNawfal
BREAKING: HOUSE FINDS EVIDENCE OF COVID LAB LEAK
The House Select Subcommittee on the Coronavirus Pandemic has examined classified State Department records that suggest COVID-19 may have originated from a lab-related accident in Wuhan, China.
The records, which were partially revealed through a FOIA request by U.S. Right to Know, also indicate potential obstruction by the Chinese Communist Party in the investigation of the virus's origins.
These findings have prompted calls from Subcommittee Chairman Brad Wenstrup for the immediate declassification of the documents to provide a full account to the public.
The Subcommittee seeks a briefing with the State Department before May 14, 2024, to further examine the evidence.
Source: Select Subcommittee on the Coronavirus Pandemic, U.S. House of Representatives
View: https://twitter.com/MarioNawfal/status/1787994597160788462
@MarioNawfal
BREAKING: HOUSE FINDS EVIDENCE OF COVID LAB LEAK
The House Select Subcommittee on the Coronavirus Pandemic has examined classified State Department records that suggest COVID-19 may have originated from a lab-related accident in Wuhan, China.
The records, which were partially revealed through a FOIA request by U.S. Right to Know, also indicate potential obstruction by the Chinese Communist Party in the investigation of the virus's origins.
These findings have prompted calls from Subcommittee Chairman Brad Wenstrup for the immediate declassification of the documents to provide a full account to the public.
The Subcommittee seeks a briefing with the State Department before May 14, 2024, to further examine the evidence.
Source: Select Subcommittee on the Coronavirus Pandemic, U.S. House of Representatives
View: https://twitter.com/MarioNawfal/status/1787994597160788462
Heliobas Disciple
TB Fanatic
Study identifies signifiers of severe COVID-19 disease and death
Why do some people with COVID-19 experience little more than a sniffle while others end up on a ventilator? And among critically ill patients, why do some eventually recover while others do not?
Study identifies signifiers of severe COVID-19 disease and death
by Isabella Backman, Yale University
May 7, 2024
Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI176640
Why do some people with COVID-19 experience little more than a sniffle while others end up on a ventilator? And among critically ill patients, why do some eventually recover while others do not?
A new study has unveiled clues for helping scientists predict who is most at risk for severe COVID-19, and among those who experience severe disease, who is most likely to survive. The researchers published their findings in the Journal of Clinical Investigation on May 1.
The study drew on data from the Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study, a partnership between the National Institute of Allergy and Infectious Diseases (NIAID) and 15 research institutions across the country, including Yale School of Medicine (YSM).
Collaborators conducted extensive analyses across many different aspects of the immune responses of more than 1,000 patients across the country. They assessed samples during hospitalization and for up to a year post-hospitalization to better understand the disease's heterogeneity.
The IMPACC multiomics approach, which combines multiple "omics" such as genomics, proteomics, and transcriptomics, is one of the largest and most comprehensive analyses to date.
COVID-19 has a vast array of manifestations in patients. To identify distinguishing features leading to different patient responses, IMPACC is using a systems immunology approach pioneered by the NIAID Human Immunology Project Consortium (HIPC) of the National Institute of Allergy and Infectious Diseases (NIAID).
The HIPC is directed at Yale by IMPACC members Ruth R. Montgomery, Ph.D., professor of medicine and of epidemiology (microbial diseases) and associate dean for scientific affairs at YSM, and David A. Hafler, MD, chair and William S. and Lois Stiles Edgerly Professor of Neurology.
Steven Kleinstein, Ph.D., Anthony N. Brady Professor of Pathology at YSM, also a HIPC investigator, led the multi-site IMPACC data analysis working group to process the individual data types for integrated analysis by the consortium informatics experts.
"My group was tasked with taking the millions of datapoints from these 1,000-plus individuals and using modeling to elucidate reasons why different people respond to COVID-19 differently and the molecular mechanisms behind it," says Jeremy Gygi, a Ph.D. candidate in Yale's computational biology and bioinformatics program and first author of the study.
New models look for patterns linked to COVID-19 outcomes
In their latest study, Gygi and the team wanted to identify signatures associated with severe COVID-19 infection and mortality. Furthermore, they examined interactions of these hallmarks to better understand the underlying immune cascade that occurs in critical cases.
"We didn't just look at someone's genes, proteins, and metabolites separately," says Gygi. "Instead, we examined how transcriptomic, proteomic, and metabolomic profiles for an individual work together in order to explain an outcome."
"This could be the largest-scale COVID-19 study by far that has looked at so many different 'omics' simultaneously and over time," adds Leying Guan, Ph.D., assistant professor of biostatistics at the Yale School of Public Health and the study's senior author.
"These are unique aspects of our study and have enabled us to do more than what's been done in the previous literature on COVID-19 biomarkers."
To achieve this, the team leveraged the IMPACC dataset and a computational method known as latent factor modeling. These models helped the researchers identify coordinated patterns among the multitude of assays they studied.
Their models had two main tasks. First, they wanted to identify drivers of severe disease. They looked for predictors that associated with the cohort's five clinical trajectory groups, with five being the most severe, and with the distinct trajectories of disease. Second, among the most severe groups, the researchers also looked for signatures predictive of mortality.
"We were trying to separate those who needed hospitalization and ventilation and survived, and those who did not," says Gygi.
Study identifies signifiers of severe COVID-19 disease and death
The severity model identified multiple factors significantly associated with COVID-19 disease trajectory, including inflammation, T cell lymphopenia, and catabolism of the amino acid tryptophan.
While many of these signatures had been identified in the COVID-19 literature, the new models added a temporal element to reveal how these hallmarks evolved over time and interacted with one another.
Among the two most severe groups, an elevated discoordination of interferon signaling, which plays a vital role in immune response, significantly predicted mortality.
"For the severity cohort, although the hallmarks we found were already well-known, we identified an additional layer of interaction," says Guan. "Among the mortality cohort, we found an important type of dysregulation [of interferon signaling] that may characterize the fate of hospitalized patients."
This study is a significant achievement and an exciting starting point, the researchers say, and they have plans to build on this work to better understand more aspects of COVID-19. For example, they hope to use similar modeling techniques to gain a better understanding of long COVID and how it develops after an acute infection.
By learning more about the intricacies of COVID-19's underlying mechanisms, they hope to pave the way for new insights into more effective treatments for both acute and lingering disease.
More information: Jeremy P. Gygi et al, Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality, Journal of Clinical Investigation (2024). DOI: 10.1172/JCI176640
Journal information: Journal of Clinical Investigation
Provided by Yale University
Heliobas Disciple
TB Fanatic
Ion channel discovery offers hope for long COVID patients
Researchers from Griffith University's National Center for Neuroimmunology and Emerging Diseases (NCNED) have made a discovery that could bring relief to those struggling with long COVID.
Ion channel discovery offers hope for long COVID patients
by Griffith University
May 7, 2024
Researchers from Griffith University's National Center for Neuroimmunology and Emerging Diseases (NCNED) have made a discovery that could bring relief to those struggling with long COVID.
In a world-first finding, they've identified a way to restore the faulty function of ion channels on immune cells using a well-known drug typically used for other medical purposes.
The breakthrough, published in the journal Frontiers in Immunology, builds on previous research showing long COVID patients share similar issues with ion channels as those with chronic fatigue syndrome (also known as myalgic encephalomyelitis or ME/CFS).
The team had previously shown success in restoring ion channel function in ME/CFS patients using a drug called Naltrexone, and now they've achieved similar results with long COVID patients.
First author Ph.D. candidate Etianne Sasso said the research team had previously reported restoring the function of these ion channels of immune cells in laboratory trials.
"Ion channels are integral membrane proteins that facilitate the passage of ions (charged particles) across the cell membrane," Sasso said.
"We found that by restoring the function of these ion channels, important ions such as calcium were again able to move in and out of immune cells, controlling many of the body's biological processes."
This breakthrough offers hope for alleviating various ME/CFS symptoms, including brain fog, muscle fatigue, and issues with the cardiovascular and gastrointestinal systems.
Professor Sonya Marshall-Gradisnik, senior author and Director of NCNED, said the significance of this discovery, achieved through the gold standard test called electrophysiology, will help in better understanding long COVID and ME/CFS paving the way for potential therapies.
The NCNED is preparing to launch two clinical trials, one for long COVID and another for ME/CFS, testing the effectiveness of low-dose Naltrexone.
This drug, typically used for opioid addiction, has shown promising results in restoring ion channel function in previous research and in anecdotal reports from patients.
"We will be undertaking two clinical trials testing the efficacy of low dose naltrexone where the first will be in long COVID patients while the second trial will, for the first time, be in ME/CFS patients," Professor Marshall-Gradisnik said.
"Should these trials prove successful, it could mean a vastly improved quality of life for countless individuals struggling with long COVID and ME/CFS."
More information: Etianne Martini Sasso et al, Investigation into the restoration of TRPM3 ion channel activity in post-COVID-19 condition: a potential pharmacotherapeutic target, Frontiers in Immunology (2024). DOI: 10.3389/fimmu.2024.1264702
Journal information: Frontiers in Immunology
Provided by Griffith University
Heliobas Disciple
TB Fanatic
(fair use applies)
Zinc's Role In Immunity And Its Impact On COVID-19
Nikhil Prasad Fact checked by:Thailand Medical News Team
May 08, 2024
Zinc (Zn) stands out as a vital micronutrient crucial for bolstering the immune system, supporting cellular activities, and combating infectious diseases. An insufficiency of Zn can lead to an immune system imbalance, particularly evident in severe deficiencies that heighten susceptibility to various viral infections, including COVID-19 caused by SARS-CoV-2. This COVID-19 News report covers a comprehensive study review by researchers from the Second Affiliated Hospital of Guilin Medical University-China and Guilin Medical University-China that delves into Zn's nutritional roles in human health, its pivotal role in immune system function and cell signaling, and its relevance in the context of COVID-19 infections. Through an in-depth exploration, this article aims to shed light on the critical importance of Zn in immune system modulation and its potential implications for COVID-19 management and therapy.
Thailand Medical News had previously covered numerous studies showing merits of Zinc in COVID-19.
https://www.thailandmedical.news/ne...isk-of-covid-19-infection-and-hospitalization
https://www.thailandmedical.news/ne...zinc-does-help-in-covid-19-clinical-outcomes-
https://www.thailandmedical.news/ne...mega-3-fatty-acids-and-zinc-helps-in-covid-19
https://www.thailandmedical.news/ne...-repurposed-drugs-efficacy-against-sars-cov-2
https://www.thailandmedical.news/ne...reased-risk-of-mortality-in-covid-19-patients
https://www.thailandmedical.news/ne...ects-of-intravenous-zinc-in-covid-19-patients
The Nutritional Importance of Zinc in Human Health
-Zinc in Human Health: An Overview
In the adult human body, approximately 2-3?g of Zn is present, primarily distributed across various tissues such as skeletal muscles, bones, and skin. Zn plays a critical role in the synthesis of proteins, acts as an activator for numerous enzymes, and participates in biochemical reactions essential for growth, development, and immune system functionality. The body's daily Zn requirement, obtained from dietary sources, is crucial for maintaining Zn homeostasis.
-Maintaining Zinc Concentration in the Body
Zn homeostasis is primarily regulated through gastrointestinal absorption and excretion mechanisms. Absorption occurs in the proximal small bowel, and factors such as phytic acid, casein, and other trace elements can influence Zn absorption. Maintaining a balance between Zn and other minerals like copper is vital, as disruptions can lead to health complications.
-Zinc Uptake in Humans
Recommended daily Zn intake varies across countries, with sources like meats, whole grains, legumes, and shellfish providing significant amounts. Zn deficiency can result in growth impairments, anemia, and compromised wound healing, highlighting the importance of adequate Zn intake for overall health.
Zinc and Immunity: Understanding the Link
-Zinc's Central Role in Immunity
Zn plays a pivotal role in immune system modulation by regulating cytokine expression, suppressing inflammation, and activating antioxidant enzymes. Its deficiency can impair immune cell function, leading to increased susceptibility to infections.
-Zinc's Impact on Immune Cells
Zn enhances the actions of immune cells such as neutrophils, B cells, natural killer (NK) cells, and T cells. It aids in the development, activation, and function of these cells, crucial for mounting effective immune responses against pathogens.
-Zinc's Role in Immune Reaction Regulation
Zn acts as an intracellular signaling molecule, influencing the production of pro-inflammatory cytokines like interleukin-1 (IL-1) and interleukin-6 (IL-6). It also modulates T cell responses, balancing TH1 and TH2 subsets, and impacting immune defense mechanisms.
-Zinc's Impact on Immune Responses - Insights from Studies
Studies in animals and humans have highlighted Zn's significant impact on immune responses, with Zn deficiency leading to dysfunctions in both innate and adaptive immunity. Zn supplementation has been associated with reduced inflammatory responses and improved immune function.
The Potential Role of Zinc in Preventing COVID-19
-Clinical Study of Zinc in COVID-19 Treatment
COVID-19 patients often exhibit low Zn levels, and studies suggest that Zn supplementation could aid in combating the virus. Clinical interventions combining Zn with other agents have shown promising results in improving antibody response and reducing disease severity.
One notable finding from these studies is that patients receiving a combination of zinc and vitamin C tend to mount a more robust antibody response against SARS-CoV-2. This suggests that zinc supplementation could play a role in stimulating the production of antibodies essential for fighting the virus.
Another promising aspect of zinc supplementation is its ability to reduce the severity of COVID-19 symptoms. Studies have indicated that patients treated with zinc therapies experience milder disease courses, shorter recovery times, and reduced risk of developing severe complications.
In addition to zinc supplementation, researchers have explored the effectiveness of combining zinc with other medications or interventions. For instance, the combination of doxycycline and zinc has shown a protective effect in COVID-19 patients, indicating the potential of synergistic treatments in combating the virus.
-Mechanism of Zinc Treatment for COVID-19
Zn's mechanisms in inhibiting SARS-CoV-2 include impairing viral replication, regulating immune responses, and preventing virus entry into host cells. Zn supplementation has demonstrated efficacy in COVID-19 treatment, contributing to reduced severity and improved outcomes.
The effect of zinc on immune cells
Zinc exhibits direct antiviral properties by impairing the replication of SARS-CoV-2. One mechanism involves zinc's inhibition of the main protease essential for viral replication. By targeting this crucial enzyme, zinc can effectively limit the virus's ability to multiply and spread within the body.
Beyond its antiviral effects, zinc plays a crucial role in regulating immune responses. Zinc supplementation has been shown to modulate cytokine production, reduce inflammation, and enhance the overall functioning of immune cells. These immunomodulatory properties contribute to a more effective immune response against COVID-19.
Another mechanism by which zinc aids in COVID-19 treatment is through its ability to prevent virus entry into host cells. Zinc interacts with cellular receptors like ACE2, which the virus uses to gain entry into cells. By stabilizing these receptors or inhibiting virus-cell interactions, zinc helps thwart SARS-CoV-2 infection at its initial stages.
Clinical evidence suggests that zinc supplementation not only reduces disease severity but also improves patient outcomes and recovery rates.
Conclusion
Unraveling Zinc's Potential in Immunity and COVID-19 In conclusion, Zn emerges as a crucial element in maintaining immune system integrity and combating infectious diseases like COVID-19. Further research into Zn's diverse roles in immune system functions, its interactions with other nutrients, and its therapeutic potential in viral infections is warranted. Understanding Zn's multifaceted contributions to immunity holds promise for enhancing preventive and therapeutic strategies against infectious diseases, including the ongoing COVID-19 pandemic.
The study findings were published in the peer reviewed journal: Frontiers in Nutrition.
www.frontiersin.org
Read Also:
https://www.thailandmedical.news/ne...covid-era-as-a-result-of-zinc-supplementation
https://www.thailandmedical.news/ne...th-chronic-epipharyngitis-using-zinc-chloride
https://www.thailandmedical.news/ne...t-help-in-common-cold--(influenza)-infections
Zinc's Role In Immunity And Its Impact On COVID-19
Nikhil Prasad Fact checked by:Thailand Medical News Team
May 08, 2024
Zinc (Zn) stands out as a vital micronutrient crucial for bolstering the immune system, supporting cellular activities, and combating infectious diseases. An insufficiency of Zn can lead to an immune system imbalance, particularly evident in severe deficiencies that heighten susceptibility to various viral infections, including COVID-19 caused by SARS-CoV-2. This COVID-19 News report covers a comprehensive study review by researchers from the Second Affiliated Hospital of Guilin Medical University-China and Guilin Medical University-China that delves into Zn's nutritional roles in human health, its pivotal role in immune system function and cell signaling, and its relevance in the context of COVID-19 infections. Through an in-depth exploration, this article aims to shed light on the critical importance of Zn in immune system modulation and its potential implications for COVID-19 management and therapy.
Thailand Medical News had previously covered numerous studies showing merits of Zinc in COVID-19.
https://www.thailandmedical.news/ne...isk-of-covid-19-infection-and-hospitalization
https://www.thailandmedical.news/ne...zinc-does-help-in-covid-19-clinical-outcomes-
https://www.thailandmedical.news/ne...mega-3-fatty-acids-and-zinc-helps-in-covid-19
https://www.thailandmedical.news/ne...-repurposed-drugs-efficacy-against-sars-cov-2
https://www.thailandmedical.news/ne...reased-risk-of-mortality-in-covid-19-patients
https://www.thailandmedical.news/ne...ects-of-intravenous-zinc-in-covid-19-patients
The Nutritional Importance of Zinc in Human Health
-Zinc in Human Health: An Overview
In the adult human body, approximately 2-3?g of Zn is present, primarily distributed across various tissues such as skeletal muscles, bones, and skin. Zn plays a critical role in the synthesis of proteins, acts as an activator for numerous enzymes, and participates in biochemical reactions essential for growth, development, and immune system functionality. The body's daily Zn requirement, obtained from dietary sources, is crucial for maintaining Zn homeostasis.
-Maintaining Zinc Concentration in the Body
Zn homeostasis is primarily regulated through gastrointestinal absorption and excretion mechanisms. Absorption occurs in the proximal small bowel, and factors such as phytic acid, casein, and other trace elements can influence Zn absorption. Maintaining a balance between Zn and other minerals like copper is vital, as disruptions can lead to health complications.
-Zinc Uptake in Humans
Recommended daily Zn intake varies across countries, with sources like meats, whole grains, legumes, and shellfish providing significant amounts. Zn deficiency can result in growth impairments, anemia, and compromised wound healing, highlighting the importance of adequate Zn intake for overall health.
Zinc and Immunity: Understanding the Link
-Zinc's Central Role in Immunity
Zn plays a pivotal role in immune system modulation by regulating cytokine expression, suppressing inflammation, and activating antioxidant enzymes. Its deficiency can impair immune cell function, leading to increased susceptibility to infections.
-Zinc's Impact on Immune Cells
Zn enhances the actions of immune cells such as neutrophils, B cells, natural killer (NK) cells, and T cells. It aids in the development, activation, and function of these cells, crucial for mounting effective immune responses against pathogens.
-Zinc's Role in Immune Reaction Regulation
Zn acts as an intracellular signaling molecule, influencing the production of pro-inflammatory cytokines like interleukin-1 (IL-1) and interleukin-6 (IL-6). It also modulates T cell responses, balancing TH1 and TH2 subsets, and impacting immune defense mechanisms.
-Zinc's Impact on Immune Responses - Insights from Studies
Studies in animals and humans have highlighted Zn's significant impact on immune responses, with Zn deficiency leading to dysfunctions in both innate and adaptive immunity. Zn supplementation has been associated with reduced inflammatory responses and improved immune function.
The Potential Role of Zinc in Preventing COVID-19
-Clinical Study of Zinc in COVID-19 Treatment
COVID-19 patients often exhibit low Zn levels, and studies suggest that Zn supplementation could aid in combating the virus. Clinical interventions combining Zn with other agents have shown promising results in improving antibody response and reducing disease severity.
One notable finding from these studies is that patients receiving a combination of zinc and vitamin C tend to mount a more robust antibody response against SARS-CoV-2. This suggests that zinc supplementation could play a role in stimulating the production of antibodies essential for fighting the virus.
Another promising aspect of zinc supplementation is its ability to reduce the severity of COVID-19 symptoms. Studies have indicated that patients treated with zinc therapies experience milder disease courses, shorter recovery times, and reduced risk of developing severe complications.
In addition to zinc supplementation, researchers have explored the effectiveness of combining zinc with other medications or interventions. For instance, the combination of doxycycline and zinc has shown a protective effect in COVID-19 patients, indicating the potential of synergistic treatments in combating the virus.
-Mechanism of Zinc Treatment for COVID-19
Zn's mechanisms in inhibiting SARS-CoV-2 include impairing viral replication, regulating immune responses, and preventing virus entry into host cells. Zn supplementation has demonstrated efficacy in COVID-19 treatment, contributing to reduced severity and improved outcomes.
The effect of zinc on immune cells
Zinc exhibits direct antiviral properties by impairing the replication of SARS-CoV-2. One mechanism involves zinc's inhibition of the main protease essential for viral replication. By targeting this crucial enzyme, zinc can effectively limit the virus's ability to multiply and spread within the body.
Beyond its antiviral effects, zinc plays a crucial role in regulating immune responses. Zinc supplementation has been shown to modulate cytokine production, reduce inflammation, and enhance the overall functioning of immune cells. These immunomodulatory properties contribute to a more effective immune response against COVID-19.
Another mechanism by which zinc aids in COVID-19 treatment is through its ability to prevent virus entry into host cells. Zinc interacts with cellular receptors like ACE2, which the virus uses to gain entry into cells. By stabilizing these receptors or inhibiting virus-cell interactions, zinc helps thwart SARS-CoV-2 infection at its initial stages.
Clinical evidence suggests that zinc supplementation not only reduces disease severity but also improves patient outcomes and recovery rates.
Conclusion
Unraveling Zinc's Potential in Immunity and COVID-19 In conclusion, Zn emerges as a crucial element in maintaining immune system integrity and combating infectious diseases like COVID-19. Further research into Zn's diverse roles in immune system functions, its interactions with other nutrients, and its therapeutic potential in viral infections is warranted. Understanding Zn's multifaceted contributions to immunity holds promise for enhancing preventive and therapeutic strategies against infectious diseases, including the ongoing COVID-19 pandemic.
The study findings were published in the peer reviewed journal: Frontiers in Nutrition.
The nutritional roles of zinc for immune system and COVID-19 patients
Zinc (Zn) is a vital micronutrient that strengthens the immune system, aids cellular activities, and treats infectious diseases. A deficiency in Zn can lead to an imbalance in the immune system. This imbalance is particularly evident in severe deficiency cases, where there is a high...
Read Also:
https://www.thailandmedical.news/ne...covid-era-as-a-result-of-zinc-supplementation
https://www.thailandmedical.news/ne...th-chronic-epipharyngitis-using-zinc-chloride
https://www.thailandmedical.news/ne...t-help-in-common-cold--(influenza)-infections
Heliobas Disciple
TB Fanatic
AstraZeneca withdraws Covid-19 vaccine worldwide, citing surplus of newer vaccines
Pharmaceutical company says newer shots led to decline in demand for AstraZeneca vaccine, which is no longer being manufactured or supplied
www.theguardian.com
AstraZeneca withdraws Covid-19 vaccine worldwide, citing surplus of newer vaccines
Pharmaceutical company says newer shots led to decline in demand for AstraZeneca vaccine, which is no longer being manufactured or supplied
Melissa Davey
Tue 7 May 2024 22.18 EDT
AstraZeneca has begun the worldwide withdrawal of its Covid-19 vaccine due to a “surplus of available updated vaccines” that target new variants of the virus.
The announcement follows the pharmaceutical company in March voluntarily withdrawing its European Union marketing authorisation, which is the approval to market a medicine in member states.
On 7 May, the European Medicines Agency issued a notice that the vaccine is no longer authorised for use.
In a statement, AstraZeneca said the decision was made because there is now a variety of newer vaccines available that have been adapted to target Covid-19 variants. This had led to a decline in demand for the AstraZeneca vaccine, which is no longer being manufactured or supplied.
“According to independent estimates, over 6.5 million lives were saved in the first year of use alone and over 3bn doses were supplied globally,” the statement said.
“Our efforts have been recognised by governments around the world and are widely regarded as being a critical component of ending the global pandemic. We will now work with regulators and our partners to align on a clear path forward to conclude this chapter and significant contribution to the Covid-19 pandemic.”
Other countries have already stopped supplying the vaccine. It has not been available for use in Australia since March 2023, though its use was already being phased out from June 2021 due to the widespread availability of newer vaccines.
AstraZeneca changed the name of its Covid vaccine to Vaxzevria in 2021. The vaccine was authorised for use in those aged 18 and older, delivered as two injections, usually into the muscle of the upper arm, about three month apart. It was also used by some countries as a booster shot.
Vaxzevria is made up of another virus of the adenovirus family modified to contain the gene for making a protein from SARS-CoV-2, the virus that causes Covid-19. The vaccine does not contain the virus itself and cannot cause the virus.
Although the vaccine was found to be safe and effective overall, it carried the risk of a rare but serious side-effect, known as thrombosis with thrombocytopenia, or TTS. The rare syndrome occurred in about two to three people per 100,000 who were vaccinated with the Vaxzevria vaccine.
The chair of epidemiology at Deakin University in Australia, Prof Catherine Bennett, said the vaccine had played a pivotal part in the worldwide fight against the virus, particularly in the early days of the pandemic when limited vaccines were available.
“It has saved millions of lives and that should not be forgotten,” she said.
“It was a really important part of the initial global response. However, it targeted the initial ancestral variants. We’ve now moved into a vaccine chain where we have products available that are chasing the variants that are emerging.
“There’s also a shift in the risk calculus as well, given populations are much more protected and, even though of course Covid still causes deaths, we are overall less vulnerable to the disease.”
The latest Covid-19 vaccine advice issued by the World Health Organisation in April advised that formulations of Covid-19 vaccines should target the JN.1 lineage of the virus, which is displacing existing XBB lineage variants.
Heliobas Disciple
TB Fanatic
NOTE THAT THIS INVESTIGATION HAD TO BE DONE AND REPORTED ON BY THE BRITISH MEDICAL JOURNAL. NO AMERICAN JOURNAL WOULD RESEARCH OR REPORT ON THIS. 
oh, and it's not like we didn't already know this... but this is more 'official' than the woo conspiracy realists.
medicalxpress.com
(fair use applies)
New research reports on financial entanglements between FDA chiefs and the drug industry
by British Medical Journal
May 8, 2024
An investigation published by The BMJ today raises concerns about financial entanglements between US Food and Drug Administration (FDA) chiefs and the drug and medical device companies they are responsible for regulating.
Regulations prohibit FDA employees from holding financial interests in any FDA "significantly regulated organization" and the FDA says it takes conflicts of interest seriously, but Peter Doshi, senior editor at The BMJ, finds that financial interests with the drug industry are common among its leaders.
Doshi reports that nine of the FDA's past 10 commissioners went on to work for the drug industry or serve on the board of directors of a drug company. That includes Margaret Hamburg, who led FDA between 2009 and 2015, but whose story is less well known.
Like her colleagues, Margaret Hamburg had relationships with FDA regulated companies before and after her stint at the FDA's helm, explains Doshi. But unlike her colleagues, Hamburg was allowed to hold financial interests in Renaissance Technologies (RenTec), an exclusive hedge fund managed by her husband's company, which The BMJ has found consistently invested in FDA-regulated drug companies during Hamburg's time at the FDA.
Following a review by the Office of Government Ethics (OGE), and before becoming FDA commissioner, Hamburg pledged to resign from more than 10 non-profit organizations at which she held a senior position and from the board of a health care products supplier company, Henry Schein.
Hamburg's husband, Peter Brown, sold his stock in Johnson & Johnson and Merck, among others, and the couple divested from several fund holdings at RenTec.
But Brown kept his job at RenTec, and they were both allowed to keep their holdings in its flagship product, the Medallion Fund, which according to financial declarations, earned them more than $3 million between 2009 and 2010.
Both the OGE and FDA declined to provide The BMJ with any specifics about Hamburg's relationships with RenTec.
According to an unnamed "administration official" the couple were allowed to retain their holdings in Medallion because the fund is based on programming that "does not allow for human tracking or input except in rare instances."
But the degree to which the algorithm controlling Medallion operated without human input was called into question by a 2014 Senate investigation into the abuse of structured financial products, in which Brown explained that the algorithm was frequently modified by programmers.
Brown did not respond to The BMJ's request for an interview. However, a review of quarterly reports by The BMJ filed during Hamburg's tenure at FDA shows that RenTec held stock in three major drug companies—Amgen, Novo Nordisk, and AstraZeneca—at an average value of $518 million. Across 10 drug companies, the reports indicate average holdings of over $1 billion.
"The facts raise concerns over the adequacy of current rules governing financial holdings by FDA commissioners," writes Doshi.
Hamburg also declined an interview request from The BMJ, but emailed a response through her personal communications agent: "In my capacity as a physician and a government official, I have always taken my ethical obligations very seriously. Prior to my confirmation as FDA commissioner, the US Senate and the Office of Government Ethics (OGE) thoroughly evaluated any potential conflicts, including those that might arise as a result of my husband's position. Those potential conflicts were addressed in signed ethics agreements, and submitted financial disclosure reports were reviewed annually by the OGE during my tenure as commissioner."
More information: Investigation: Revolving doors: board memberships, hedge funds, and the FDA chiefs responsible for regulating industry, The BMJ (2024). DOI: 10.1136/bmj.q975
Journal information: British Medical Journal (BMJ)
Provided by British Medical Journal
oh, and it's not like we didn't already know this... but this is more 'official' than the woo conspiracy realists.
New research reports on financial entanglements between FDA chiefs and the drug industry
An investigation published by The BMJ today raises concerns about financial entanglements between US Food and Drug Administration (FDA) chiefs and the drug and medical device companies they are responsible for regulating.
New research reports on financial entanglements between FDA chiefs and the drug industry
by British Medical Journal
May 8, 2024
An investigation published by The BMJ today raises concerns about financial entanglements between US Food and Drug Administration (FDA) chiefs and the drug and medical device companies they are responsible for regulating.
Regulations prohibit FDA employees from holding financial interests in any FDA "significantly regulated organization" and the FDA says it takes conflicts of interest seriously, but Peter Doshi, senior editor at The BMJ, finds that financial interests with the drug industry are common among its leaders.
Doshi reports that nine of the FDA's past 10 commissioners went on to work for the drug industry or serve on the board of directors of a drug company. That includes Margaret Hamburg, who led FDA between 2009 and 2015, but whose story is less well known.
Like her colleagues, Margaret Hamburg had relationships with FDA regulated companies before and after her stint at the FDA's helm, explains Doshi. But unlike her colleagues, Hamburg was allowed to hold financial interests in Renaissance Technologies (RenTec), an exclusive hedge fund managed by her husband's company, which The BMJ has found consistently invested in FDA-regulated drug companies during Hamburg's time at the FDA.
Following a review by the Office of Government Ethics (OGE), and before becoming FDA commissioner, Hamburg pledged to resign from more than 10 non-profit organizations at which she held a senior position and from the board of a health care products supplier company, Henry Schein.
Hamburg's husband, Peter Brown, sold his stock in Johnson & Johnson and Merck, among others, and the couple divested from several fund holdings at RenTec.
But Brown kept his job at RenTec, and they were both allowed to keep their holdings in its flagship product, the Medallion Fund, which according to financial declarations, earned them more than $3 million between 2009 and 2010.
Both the OGE and FDA declined to provide The BMJ with any specifics about Hamburg's relationships with RenTec.
According to an unnamed "administration official" the couple were allowed to retain their holdings in Medallion because the fund is based on programming that "does not allow for human tracking or input except in rare instances."
But the degree to which the algorithm controlling Medallion operated without human input was called into question by a 2014 Senate investigation into the abuse of structured financial products, in which Brown explained that the algorithm was frequently modified by programmers.
Brown did not respond to The BMJ's request for an interview. However, a review of quarterly reports by The BMJ filed during Hamburg's tenure at FDA shows that RenTec held stock in three major drug companies—Amgen, Novo Nordisk, and AstraZeneca—at an average value of $518 million. Across 10 drug companies, the reports indicate average holdings of over $1 billion.
"The facts raise concerns over the adequacy of current rules governing financial holdings by FDA commissioners," writes Doshi.
Hamburg also declined an interview request from The BMJ, but emailed a response through her personal communications agent: "In my capacity as a physician and a government official, I have always taken my ethical obligations very seriously. Prior to my confirmation as FDA commissioner, the US Senate and the Office of Government Ethics (OGE) thoroughly evaluated any potential conflicts, including those that might arise as a result of my husband's position. Those potential conflicts were addressed in signed ethics agreements, and submitted financial disclosure reports were reviewed annually by the OGE during my tenure as commissioner."
More information: Investigation: Revolving doors: board memberships, hedge funds, and the FDA chiefs responsible for regulating industry, The BMJ (2024). DOI: 10.1136/bmj.q975
Journal information: British Medical Journal (BMJ)
Provided by British Medical Journal
Heliobas Disciple
TB Fanatic
(fair use applies)
Scientists Warn That Viral Persistence Is The Primary Contributing Factor To Long COVID
Nikhil Prasad Fact checked by:Thailand Medical News Team
May 09, 2024
The global outbreak of COVID-19 caused by the SARS-CoV-2 virus has brought to light not only the acute phase of the illness but also lingering health complications that persist long after the initial infection. Known as Post-Acute Sequelae of SARS-CoV-2 (PASC), or more colloquially as Long COVID, this condition has captured the attention of scientists worldwide due to its complex and diverse nature. In this Long COVID News report based on a study review by researchers from University of Padova- Italy and University of Maryland-USA, we delve into the intricate details of Long COVID, exploring the contributing factors, potential mechanisms, and ongoing research in this field.
Graphical Abstract: Viral Persistence Is The Primary Contributing Factor To Long COVID
Thailand Medical News has already warning about SARS-CoV-2 viral persistence since 2020.
www.thailandmedical.news
https://www.thailandmedical.news/ne...uctures-that-contributes-to-viral-persistence
https://www.thailandmedical.news/ne...ations-for-viral-persistence-and-misc-dangers
https://www.thailandmedical.news/ne...rain-and-cause-relapses-in-recovered-patients
https://www.thailandmedical.news/ne...s-for-sars-cov-2-and-are-potential-reservoirs
https://www.thailandmedical.news/ne...9-after-testing-negative-via-nasal-swab-tests
https://www.thailandmedical.news/ne...ence-in-children-and-young-adults-with-cancer
https://www.thailandmedical.news/ne...t-covid-19-patients-up-to-15-months-after-so-
https://www.thailandmedical.news/ne...-she-was-diagnosed-with-asymptomatic-covid-19
https://www.thailandmedical.news/ne...the-brain-even-in-those-who-were-asymptomatic
https://www.thailandmedical.news/ne...viral-persistence-is-real-and-a-serious-issue
https://www.thailandmedical.news/ne...stence-as-it-is-better-at-evading-host-s-immu
https://www.thailandmedical.news/ne...-death-indicating-long-term-viral-persistence
https://www.thailandmedical.news/ne...-and-appendix-tissues-of-two-patients-with-lo
https://www.thailandmedical.news/ne...in-tissues-for-months-in-post-covid-individua
https://www.thailandmedical.news/ne...tect-viral-persistence-let-alone-new-variants
https://www.thailandmedical.news/ne...al-rna-compared-to-those-with-acute-infection
https://www.thailandmedical.news/ne...tides-similar-to-retrotransposons-and-introns
https://www.thailandmedical.news/ne...sars-cov-2-antigen-and-rna-in-various-tissues
https://www.thailandmedical.news/ne...-phase-of-disease-even-in-the-negative-tested
https://www.thailandmedical.news/ne...rious-issue-that-is-also-affecting-long-covid
https://www.thailandmedical.news/ne...types,-providing-evidence-of-viral-reservoirs
https://www.thailandmedical.news/ne...-sars-cov-2-in-corpses-of-patients-with-covid
https://www.thailandmedical.news/ne...eads-and-are-better-adapted-for-viral-persist
https://www.thailandmedical.news/ne...-viral-persistence-contributing-to-long-covid
https://www.thailandmedical.news/ne...ontinuous-presence-of-short-viral-rnas-svrnas
https://www.thailandmedical.news/ne...archers-warn-of-viral-persistence-in-the-ears
https://www.thailandmedical.news/ne...s-majority-of-so-called-recovered-individuals
https://www.thailandmedical.news/ne...stence-for-up-to-2-5-years-following-covid-19
https://www.thailandmedical.news/ne...s-of-sars-cov-2-viral-persistence-in-children
https://www.thailandmedical.news/ne...-pave-the-path-for-viral-persistence-in-lungs
https://www.thailandmedical.news/ne...ral-persistence-are-issues-causing-long-covid
https://www.thailandmedical.news/ne...rampant-sars-cov-2-viral-persistence-in-heart
https://www.thailandmedical.news/ne...r-effusion-could-be-the-cause-of-otitis-media
Post-Acute Sequelae of SARS-CoV-2
COVID-19, initially perceived as primarily a respiratory illness, has proven to have far-reaching effects beyond the lungs. Patients recovering from acute COVID-19 can experience a spectrum of symptoms collectively termed as Long COVID or PASC. These symptoms, ranging from fatigue, headaches, and attention disorders to more severe manifestations like neurological, cardiac, liver, and kidney issues, can persist for weeks to months after the acute phase of the infection. The World Health Organization (WHO) defines PASC as ongoing, relapsing, or new symptoms present 30 or more days after infection. This extended phase of illness significantly impacts the quality of life for affected individuals, necessitating a deeper understanding of its underlying mechanisms.
Factors Contributing to Long COVID
Several factors contribute to the development of Long COVID, including pre-existing health conditions like depression, anxiety, chronic kidney disease, and autoimmune diseases. Additionally, the severity of the acute phase of COVID-19 plays a role, with hospitalized patients more likely to experience PASC symptoms compared to those with mild or asymptomatic infections. Notably, certain demographics, such as women, children, and immunocompromised individuals, face heightened risks and challenges associated with Long COVID.
Viral Persistence in Long COVID
One of the primary contributing factors to Long COVID appears to be viral persistence. Studies have shown that SARS-CoV-2 antigens and RNA can persist in various organs, including the gastrointestinal tract (GIT), for extended periods even after clearance from the upper respiratory system. This persistent presence of viral elements can stimulate prolonged immune activation, shaping local microbiota and potentially leading to systemic effects. Understanding the dynamics of viral persistence is crucial in unraveling the mysteries of Long COVID.
Evidence of Viral Persistence
Research has provided compelling evidence of SARS-CoV-2 persistence in the body post-infection. Studies have detected viral RNA and antigens in diverse anatomical sites, such as the GIT, kidneys, CNS, and even bone marrow, months after acute infection. Notably, the presence of viral components correlates with the occurrence of PASC symptoms, suggesting a direct link between viral persistence and ongoing health issues in recovered COVID-19 patients.
Immune System Implications
Persistent viral elements in Long COVID contribute to prolonged immune system activation. Studies have shown chronic activation of CD8+ T-cells, expansion of dendritic cells and monocytes, and altered B cell responses in PASC patients. This immune dysregulation, coupled with factors like complement system activation and persistent antibody evolution, contributes to the pathogenesis of Long COVID symptoms, particularly those affecting the central nervous system (CNS).
Role of Gut Microbiota
The gut microbiota plays a crucial role in Long COVID, with emerging evidence linking gut dysbiosis to persistent symptoms. Changes in microbiota composition, particularly reductions in beneficial bacteria and increases in opportunistic pathogens, are associated with PASC manifestations. The gut-brain axis (GBA) may mediate these effects, highlighting the intricate interplay between the gut microbiome, immune system, and CNS function in Long COVID pathology.
Challenges and Future Directions
While significant progress has been made in understanding Long COVID, many challenges and unanswered questions remain. These include the heterogeneity of PASC symptoms, sex-specific differences in susceptibility and immune responses, and the impact of Long COVID on pediatric populations. Addressing these challenges requires multidisciplinary research efforts, including longitudinal studies, biomarker identification, and targeted therapeutic interventions.
Conclusion
Long COVID represents a complex and multifaceted condition that extends beyond the acute phase of SARS-CoV-2 infection. Viral persistence, immune dysregulation, gut microbiota alterations, and other factors contribute to the diverse array of PASC symptoms observed in affected individuals. Ongoing research aimed at unraveling the mechanisms of Long COVID and developing effective treatments is essential to mitigate the long-term impact of this pandemic on global health.
The study review was published in the peer reviewed journal: Pathogens.
www.mdpi.com
Read Also:
https://www.thailandmedical.news/ne...be-viral-sanctuaries-for-the-sars-cov-2-virus
https://www.thailandmedical.news/ne...odeficiencies-but-rather-by-viral-persistence
Scientists Warn That Viral Persistence Is The Primary Contributing Factor To Long COVID
Nikhil Prasad Fact checked by:Thailand Medical News Team
May 09, 2024
The global outbreak of COVID-19 caused by the SARS-CoV-2 virus has brought to light not only the acute phase of the illness but also lingering health complications that persist long after the initial infection. Known as Post-Acute Sequelae of SARS-CoV-2 (PASC), or more colloquially as Long COVID, this condition has captured the attention of scientists worldwide due to its complex and diverse nature. In this Long COVID News report based on a study review by researchers from University of Padova- Italy and University of Maryland-USA, we delve into the intricate details of Long COVID, exploring the contributing factors, potential mechanisms, and ongoing research in this field.
Graphical Abstract: Viral Persistence Is The Primary Contributing Factor To Long COVID
Thailand Medical News has already warning about SARS-CoV-2 viral persistence since 2020.
World COVID-19 News: Global Deaths Crosses 1.6 Million Milestone, Infections Pass 71.8 Million. Why Are Authorities Downplaying Viral Persistence? - Thailand Medical News
World COVID-19 News: The COVID-19 crisis is escalating exponentially with the total COVID-19 deaths now crossing the 1.6 million milestone and reaching more than 1,607,900 as of Sunday (1700hrs Bangkok). The total number of global COVID-19 infections has now reached more than 71.8 million...
www.thailandmedical.news
https://www.thailandmedical.news/ne...uctures-that-contributes-to-viral-persistence
https://www.thailandmedical.news/ne...ations-for-viral-persistence-and-misc-dangers
https://www.thailandmedical.news/ne...rain-and-cause-relapses-in-recovered-patients
https://www.thailandmedical.news/ne...s-for-sars-cov-2-and-are-potential-reservoirs
https://www.thailandmedical.news/ne...9-after-testing-negative-via-nasal-swab-tests
https://www.thailandmedical.news/ne...ence-in-children-and-young-adults-with-cancer
https://www.thailandmedical.news/ne...t-covid-19-patients-up-to-15-months-after-so-
https://www.thailandmedical.news/ne...-she-was-diagnosed-with-asymptomatic-covid-19
https://www.thailandmedical.news/ne...the-brain-even-in-those-who-were-asymptomatic
https://www.thailandmedical.news/ne...viral-persistence-is-real-and-a-serious-issue
https://www.thailandmedical.news/ne...stence-as-it-is-better-at-evading-host-s-immu
https://www.thailandmedical.news/ne...-death-indicating-long-term-viral-persistence
https://www.thailandmedical.news/ne...-and-appendix-tissues-of-two-patients-with-lo
https://www.thailandmedical.news/ne...in-tissues-for-months-in-post-covid-individua
https://www.thailandmedical.news/ne...tect-viral-persistence-let-alone-new-variants
https://www.thailandmedical.news/ne...al-rna-compared-to-those-with-acute-infection
https://www.thailandmedical.news/ne...tides-similar-to-retrotransposons-and-introns
https://www.thailandmedical.news/ne...sars-cov-2-antigen-and-rna-in-various-tissues
https://www.thailandmedical.news/ne...-phase-of-disease-even-in-the-negative-tested
https://www.thailandmedical.news/ne...rious-issue-that-is-also-affecting-long-covid
https://www.thailandmedical.news/ne...types,-providing-evidence-of-viral-reservoirs
https://www.thailandmedical.news/ne...-sars-cov-2-in-corpses-of-patients-with-covid
https://www.thailandmedical.news/ne...eads-and-are-better-adapted-for-viral-persist
https://www.thailandmedical.news/ne...-viral-persistence-contributing-to-long-covid
https://www.thailandmedical.news/ne...ontinuous-presence-of-short-viral-rnas-svrnas
https://www.thailandmedical.news/ne...archers-warn-of-viral-persistence-in-the-ears
https://www.thailandmedical.news/ne...s-majority-of-so-called-recovered-individuals
https://www.thailandmedical.news/ne...stence-for-up-to-2-5-years-following-covid-19
https://www.thailandmedical.news/ne...s-of-sars-cov-2-viral-persistence-in-children
https://www.thailandmedical.news/ne...-pave-the-path-for-viral-persistence-in-lungs
https://www.thailandmedical.news/ne...ral-persistence-are-issues-causing-long-covid
https://www.thailandmedical.news/ne...rampant-sars-cov-2-viral-persistence-in-heart
https://www.thailandmedical.news/ne...r-effusion-could-be-the-cause-of-otitis-media
Post-Acute Sequelae of SARS-CoV-2
COVID-19, initially perceived as primarily a respiratory illness, has proven to have far-reaching effects beyond the lungs. Patients recovering from acute COVID-19 can experience a spectrum of symptoms collectively termed as Long COVID or PASC. These symptoms, ranging from fatigue, headaches, and attention disorders to more severe manifestations like neurological, cardiac, liver, and kidney issues, can persist for weeks to months after the acute phase of the infection. The World Health Organization (WHO) defines PASC as ongoing, relapsing, or new symptoms present 30 or more days after infection. This extended phase of illness significantly impacts the quality of life for affected individuals, necessitating a deeper understanding of its underlying mechanisms.
Factors Contributing to Long COVID
Several factors contribute to the development of Long COVID, including pre-existing health conditions like depression, anxiety, chronic kidney disease, and autoimmune diseases. Additionally, the severity of the acute phase of COVID-19 plays a role, with hospitalized patients more likely to experience PASC symptoms compared to those with mild or asymptomatic infections. Notably, certain demographics, such as women, children, and immunocompromised individuals, face heightened risks and challenges associated with Long COVID.
Viral Persistence in Long COVID
One of the primary contributing factors to Long COVID appears to be viral persistence. Studies have shown that SARS-CoV-2 antigens and RNA can persist in various organs, including the gastrointestinal tract (GIT), for extended periods even after clearance from the upper respiratory system. This persistent presence of viral elements can stimulate prolonged immune activation, shaping local microbiota and potentially leading to systemic effects. Understanding the dynamics of viral persistence is crucial in unraveling the mysteries of Long COVID.
Evidence of Viral Persistence
Research has provided compelling evidence of SARS-CoV-2 persistence in the body post-infection. Studies have detected viral RNA and antigens in diverse anatomical sites, such as the GIT, kidneys, CNS, and even bone marrow, months after acute infection. Notably, the presence of viral components correlates with the occurrence of PASC symptoms, suggesting a direct link between viral persistence and ongoing health issues in recovered COVID-19 patients.
Immune System Implications
Persistent viral elements in Long COVID contribute to prolonged immune system activation. Studies have shown chronic activation of CD8+ T-cells, expansion of dendritic cells and monocytes, and altered B cell responses in PASC patients. This immune dysregulation, coupled with factors like complement system activation and persistent antibody evolution, contributes to the pathogenesis of Long COVID symptoms, particularly those affecting the central nervous system (CNS).
Role of Gut Microbiota
The gut microbiota plays a crucial role in Long COVID, with emerging evidence linking gut dysbiosis to persistent symptoms. Changes in microbiota composition, particularly reductions in beneficial bacteria and increases in opportunistic pathogens, are associated with PASC manifestations. The gut-brain axis (GBA) may mediate these effects, highlighting the intricate interplay between the gut microbiome, immune system, and CNS function in Long COVID pathology.
Challenges and Future Directions
While significant progress has been made in understanding Long COVID, many challenges and unanswered questions remain. These include the heterogeneity of PASC symptoms, sex-specific differences in susceptibility and immune responses, and the impact of Long COVID on pediatric populations. Addressing these challenges requires multidisciplinary research efforts, including longitudinal studies, biomarker identification, and targeted therapeutic interventions.
Conclusion
Long COVID represents a complex and multifaceted condition that extends beyond the acute phase of SARS-CoV-2 infection. Viral persistence, immune dysregulation, gut microbiota alterations, and other factors contribute to the diverse array of PASC symptoms observed in affected individuals. Ongoing research aimed at unraveling the mechanisms of Long COVID and developing effective treatments is essential to mitigate the long-term impact of this pandemic on global health.
The study review was published in the peer reviewed journal: Pathogens.
The Potential Role of Viral Persistence in the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
The infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated not only with the development of acute disease but also with long-term symptoms or post-acute sequelae of SARS-CoV-2 (PASC). Multiple lines of evidence support that some viral antigens and RNA can persist...
www.mdpi.com
Read Also:
https://www.thailandmedical.news/ne...be-viral-sanctuaries-for-the-sars-cov-2-virus
https://www.thailandmedical.news/ne...odeficiencies-but-rather-by-viral-persistence
Heliobas Disciple
TB Fanatic
Dr. Phillip McMillan did a video explaining Geert's last post about the mmr vaccine, posted a page up in post 70,718. Here's the direct link again to Geert's article:
voiceforscienceandsolidarity.substack.com
View: https://www.youtube.com/watch?v=j_BAnNHL1Cc
Unprecedented Proposal from Geert for Vaccinated Individuals!
Vejon Health
Streamed live May 8 2024
19 min 24 sec
Geert proposes immune retraining for the vaccinated to combat viral variants. Learn more about training the immune system in this insightful video with Dr McMillan.
The latest surge of Omicron KP.2 and KP.3 variants in highly vaccinated regions, highlights that alternative approaches to herd immunity need to be considered.
Geert Vanden Bossche was the first to highlight the risk of immune pressure on the virus through mass vaccination as the likely cause for evolving variants.
His latest update is on training immune cells with other vaccines.
https://www.voiceforscienceandsolidar...
Training is gaining! A glimmer of rational hope.
There is compelling scientific evidence indicating that mass vaccination against COVID-19 (C-19) has led to growing immune evasion of SARS-CoV-2 (SC-2) from infection- or vaccine-induced neutralizing anti-spike antibodies (Abs), along with an increasing incidence of immune pathology (
voiceforscienceandsolidarity.substack.com
Unprecedented Proposal from Geert for Vaccinated Individuals!
Vejon Health
Streamed live May 8 2024
19 min 24 sec
Geert proposes immune retraining for the vaccinated to combat viral variants. Learn more about training the immune system in this insightful video with Dr McMillan.
The latest surge of Omicron KP.2 and KP.3 variants in highly vaccinated regions, highlights that alternative approaches to herd immunity need to be considered.
Geert Vanden Bossche was the first to highlight the risk of immune pressure on the virus through mass vaccination as the likely cause for evolving variants.
His latest update is on training immune cells with other vaccines.
https://www.voiceforscienceandsolidar...
Heliobas Disciple
TB Fanatic
KEY MESSAGES from my book | Voice for Science and Solidarity
The inescapable immune escape pandemic. The inescapable immune escape pandemic. The inescapable immune escape pandemic.
www.voiceforscienceandsolidarity.org
KEY MESSAGES from my book
By Geert Vanden Bossche
May 8, 2024
I have outlined the key messages from my latest book in the PDF below.
Buy the book here: The Inescapable Immune Escape Pandemic
